Find Resorts & Hotels with Spas in Seneca, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Seneca Resorts & Hotels with Spas

No exact matches found, but these alternatives could be just right

Recommended hotels in Seneca

View from property

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (66 reviews)
"Excellent stay."
United States
Beonca
The price is ￥12,619
￥20,909 total
includes taxes & fees
Mar 18 - Mar 19
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (687 reviews)
"Everting was good"
United States
Susan
The price is ￥12,438
￥14,655 total
includes taxes & fees
Mar 21 - Mar 22
Quality Inn Seneca Clemson Area US-123
Exterior

Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
The price is ￥19,966
￥34,262 total
includes taxes & fees
Mar 16 - Mar 17
Cozy Clemson TIny House Cabin
Property amenity

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (214 reviews)
"Hotel and room were super clean. Hotel is fairly new and it shows. Nice view of Lake Keowee. Breakfast was quite good & excellent coffee. Would definitely stay there again. "
United States
Matthew
The price is ￥19,966
￥21,964 total
includes taxes & fees
Mar 19 - Mar 20
Fairfield Inn & Suites Seneca Clemson Univ Area
Aerial view

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place and location, great mattress, "
United States
Jeffrey
The price is ￥17,411
￥21,613 total
includes taxes & fees
Mar 17 - Mar 18
Lakeside Lodge Clemson
Private kitchen

The Clemson Cottage - 3.6 mi. to Memorial Stadium

The Clemson Cottage - 3.6 mi. to Memorial Stadium
Seneca
10.0 out of 10, Exceptional, (16 reviews)
"Seriously comfortable home, the beds and pillows all fantastic, nicely appointed in every way. Can’t wait to stay here again. "
United States
Susan
The price is ￥28,751
￥63,253 total
includes taxes & fees
Mar 16 - Mar 17
The Clemson Cottage - 3.6 mi. to Memorial Stadium
Terrace/patio

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (816 reviews)
"The hotel was very clean staff was amazing "
United States
Clifford
The price is ￥17,613
￥19,373 total
includes taxes & fees
Mar 23 - Mar 24
Tru by Hilton Seneca Clemson
Dining

bedroom available in my house in lovely Seneca. 5 miles from Clemson University

bedroom available in my house in lovely Seneca. 5 miles from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"Rooms were clean and host was accommodating. Room to park my boat and was able to bring my dog!"
United States
Matthew A.
The price is ￥4,600
￥10,331 total
includes taxes & fees
Mar 16 - Mar 17
bedroom available in my house in lovely Seneca. 5 miles from Clemson University
1 bedroom, WiFi, bed sheets

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (12 reviews)
"Very clean and comfortable - very close to Clemson and easy access. "
United States
Jim A.
The price is ￥23,960
￥31,627 total
includes taxes & fees
Mar 16 - Mar 17
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Interior

Private Room #3

Private Room #3
Downtown
9.2 out of 10, Wonderful, (13 reviews)
"Very clean and comfortable! Will stay again!"
United States
Joseph K.
The price is ￥22,362
￥34,661 total
includes taxes & fees
Mar 16 - Mar 17
Private Room #3
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Seneca

Pool
Breakfast included

Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2/10 Terrible
"Rooms good for the night. No issues with rooms"
Sofia 1-night trip
Posted 7 days ago
Hampton Inn & Suites Seneca-Clemson Area

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and Seneca City Hall.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.