A calm lake with mountains in the background.

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Next weekend
Aug 7 - Aug 9
In two weeks
Aug 14 - Aug 16

Our top choices for Seneca hotels with a spa

Terrace/patio

1. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (870 reviews)
The price is ￥16,650
￥18,315 total
includes taxes & fees
Aug 22 - Aug 23
Tru by Hilton Seneca Clemson
Reception

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (732 reviews)
The price is ￥18,680
￥20,547 total
includes taxes & fees
Aug 27 - Aug 28
Hampton Inn & Suites Seneca-Clemson Area
Free daily on-the-go breakfast

3. Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very Good, (741 reviews)
The price is ￥12,296
￥15,074 total
includes taxes & fees
Aug 9 - Aug 10
Quality Inn Seneca US-123
Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (681 reviews)
The price is ￥15,921
￥17,514 total
includes taxes & fees
Aug 18 - Aug 19
Best Western Seneca-Clemson
Property amenity

5. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (256 reviews)
The price is ￥20,347
￥22,383 total
includes taxes & fees
Aug 9 - Aug 10
Fairfield Inn & Suites Seneca Clemson Univ Area
Aerial view

6. Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,007 reviews)
The price is ￥17,157
￥21,298 total
includes taxes & fees
Aug 3 - Aug 4
Lakeside Lodge Clemson
Free daily on-the-go breakfast

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (772 reviews)
The price is ￥11,372
￥12,508 total
includes taxes & fees
Aug 22 - Aug 23
Days Inn by Wyndham Seneca / Clemson Area
Golf

8. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
Clemson
9.4 out of 10, Exceptional, (1,001 reviews)
The price is ￥23,453
￥26,033 total
includes taxes & fees
Sep 1 - Sep 2
Clemson University's James F. Martin Inn
Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Bathroom | Combined shower/tub, free toiletries, hair dryer, slippers

9. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
Clemson
8.4 out of 10, Very Good, (1,002 reviews)
The price is ￥16,590
￥18,415 total
includes taxes & fees
Sep 1 - Sep 2
Comfort Inn & Suites Clemson - University Area
Free breakfast

10. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.2 out of 10, Very Good, (1,002 reviews)
The price is ￥16,590
￥18,414 total
includes taxes & fees
Aug 31 - Sep 1
Best Western Plus Clemson Hotel & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Seneca

Pool
Breakfast included

Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Check in people were very friendly and polite!"
Mabel 3-night trip
Posted 20 hours ago
Hampton Inn & Suites Seneca-Clemson Area

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and Oconee County Library Seneca Branch.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.