Find Resorts & Hotels with Spas in Seneca, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Seneca Resorts & Hotels with Spas

Tonight
Jan 25 - Jan 26
Tomorrow
Jan 26 - Jan 27
Next weekend
Jan 30 - Feb 1
In two weeks
Feb 6 - Feb 8
No exact matches found, but these alternatives could be just right

Recommended hotels in Seneca

Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (672 reviews)
"Our stay was very nice. Clean room. The outside was clean. "
United States
Gayle
The price is ￥12,125
￥14,286 total
includes taxes & fees
Feb 1 - Feb 2
Quality Inn Seneca Clemson Area US-123
Aerial view

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,007 reviews)
"Great place to stay. "
United States
Gene
The price is ￥16,971
￥21,067 total
includes taxes & fees
Jan 26 - Jan 27
Lakeside Lodge Clemson
View from property

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (56 reviews)
"Excellent stay."
United States
Beonca
The price is ￥13,857
￥22,093 total
includes taxes & fees
Jan 26 - Jan 27
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (646 reviews)
"The stay was amazing "
United States
Tabatha
The price is ￥14,293
￥15,721 total
includes taxes & fees
Feb 4 - Feb 5
Best Western Seneca-Clemson
Property amenity

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
Seneca
9.4 out of 10, Exceptional, (206 reviews)
"Spotless, friendly staff, great location. "
United States
Cari
The price is ￥19,463
￥21,410 total
includes taxes & fees
Feb 1 - Feb 2
Fairfield Inn & Suites Seneca Clemson Univ Area
Terrace/patio

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (804 reviews)
"Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!"
United States
Cindy
The price is ￥15,193
￥16,712 total
includes taxes & fees
Feb 1 - Feb 2
Tru by Hilton Seneca Clemson
Reception

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (673 reviews)
"Everything was excellent "
United States
Debby
The price is ￥19,195
￥21,115 total
includes taxes & fees
Feb 8 - Feb 9
Hampton Inn & Suites Seneca-Clemson Area
Exterior

Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC

Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
Seneca
10.0 out of 10, Exceptional, (12 reviews)
"Excellent place; home away from home."
United States
Darren F.
The price is ￥17,906
￥31,685 total
includes taxes & fees
Jan 26 - Jan 27
Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
Smart TV, fireplace

Enjoy one of our RV units son less of a headache for you this vacation!

Enjoy one of our RV units son less of a headache for you this vacation!
Seneca
8.0 out of 10, Very Good, (4 reviews)
"My partner and I stayed 5 nights and we enjoyed it so much. It's such a convenient place to reside for a get away. If you're looking for that "outback" feeling but want to be cozy; look no further. Communication was always qick with responses and was more than willing to help with anything we needed! We would definitely stay again."
United States
Denise s.
The price is ￥10,790
￥23,859 total
includes taxes & fees
Feb 1 - Feb 2
Enjoy one of our RV units son less of a headache for you this vacation!
Fridge, microwave, oven, stovetop

Tucker Farm Cottage on Century Farm

Tucker Farm Cottage on Century Farm
Seneca
10.0 out of 10, Exceptional, (33 reviews)
"Excellent stay, beautiful area!"
United States
Barbara W.
The price is ￥24,912
￥60,474 total
includes taxes & fees
Jan 26 - Jan 27
Tucker Farm Cottage on Century Farm
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Seneca Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and The Gauntlet.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.