A modern building with a unique triangular roof and a central spire.

Find hotels in Santa Lucia, Syracuse

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Jul 24 - Jul 26
Next weekend
Jul 31 - Aug 2

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Lucia hotels

Breakfast area

1. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (130 reviews)
"Amazing stay. Beautiful views and everyone was very friendly. "
United States
Anna
The price is ￥32,881
￥38,027 total
includes taxes & fees
Jul 22 - Jul 23
Giuggiulena Villa
View from room

2. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (13 reviews)
"Clean, very convenient for exploring Ortigia. Nice continental breakfast."
United States
Mary
The price is ￥21,088
￥24,040 total
includes taxes & fees
Jul 20 - Jul 21
Calafatari B&B
Rooftop terrace

3. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (288 reviews)
"Beautiful hotel with good amenities"
Canada
Alessia
The price is ￥27,865
￥32,510 total
includes taxes & fees
Jul 24 - Jul 25
Caportigia Boutique Hotel
Suite, Balcony, Sea View | Minibar, in-room safe, desk, soundproofing

4. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (74 reviews)
"The room appeared to be recently remodeled and was very modern. Of the 4 hotels that we stayed at on this trip, the bed/pillows were the most comfortable. Great view of the marina from our room balcony and public parking (free) was relatively easy. "
United States
Michael
The price is ￥18,675
￥21,289 total
includes taxes & fees
Jul 27 - Jul 28
Lakkios
Superior Double Room | Frette Italian sheets, premium bedding, down comforters, desk

5. Fortuna Guest House

Fortuna Guest House
1.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (19 reviews)
"The owner was really nice and helpful! Really enjoyed our stay here."
Finland
Kirsi
The price is ￥16,905
￥19,272 total
includes taxes & fees
Jul 26 - Jul 27
Fortuna Guest House
Coffee/tea maker, electric kettle

6. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (282 reviews)
"Room clean, air-conditioning good, beds good, staff nice. Not really sound proof, but everyone is respectful and quiet during the night. Staff isn't always at the reception, but that didn't bother us. Super central, super safe. There's no lifts though."
United Kingdom
Amanda
The price is ￥11,724
￥13,364 total
includes taxes & fees
Jul 24 - Jul 25
Nostos rooms & Apartments
Suite | Soundproofing, WiFi (free)

7. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (43 reviews)
"Good central location & nice breakfast selection "
Australia
Alan
The price is ￥20,585
￥23,467 total
includes taxes & fees
Jul 26 - Jul 27
Hotel Palazzo Cavalieri
1 bedroom, down comforters, minibar, in-room safe

8. Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (58 reviews)
"Wonderful property, excellent staff and the most amazing view from the apartment"
Australia
Anthony
The price is ￥35,803
￥41,241 total
includes taxes & fees
Jul 20 - Jul 21
Re Dionisio Luxury Suites
Classic Room | View from room

9. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (42 reviews)
"Nice kitchen area, centrally located."
United States
Richard
The price is ￥11,399
￥12,994 total
includes taxes & fees
Jul 21 - Jul 22
Gymnasium
Front of property

10. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (684 reviews)
"This accommodation was very comfortable and I would highly recommend it."
Australia
Janet
The price is ￥18,513
￥21,105 total
includes taxes & fees
Jul 23 - Jul 24
Grande Albergo Alfeo
Porch

11. Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (386 reviews)
"This was my favorite stay in Sicily! I love the elevator and the staff were really nice and accommodating. I also want to point out the excellent AC inside the room. I would only suggest a bottle of water inside the room and a personal tea/ coffee station."
United States
Diane
The price is ￥13,527
￥15,421 total
includes taxes & fees
Jul 25 - Jul 26
Piccolo Hotel Casa Mia
Comfort Triple Room, Balcony, Ocean View | View from room

12. Hotel Mediterraneo

Hotel Mediterraneo
3.0 star property
Santa Lucia
7.8 out of 10, Good, (124 reviews)
"Very friendly and helpful staff."
United States
David
The price is ￥13,907
￥15,853 total
includes taxes & fees
Jul 26 - Jul 27
Hotel Mediterraneo
Exterior

13. Populus

Populus
1.0 star property
Santa Lucia
7.8 out of 10, Good, (75 reviews)
"Just stay somewhere else, plain and simple."
United States
Thomas
The price is ￥13,542
￥15,439 total
includes taxes & fees
Jul 27 - Jul 28
Populus
Triple Room, Balcony | Balcony

14. B&B Nike

B&B Nike
Santa Lucia
9.0 out of 10, Wonderful, (88 reviews)
"."
United States
Dany
The price is ￥13,203
￥15,051 total
includes taxes & fees
Jul 30 - Jul 31
B&B Nike
Lobby lounge

15. Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (17 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
The price is ￥19,968
￥22,764 total
includes taxes & fees
Aug 8 - Aug 9
Regina Margherita
Superior Triple Room, Sea View | Terrace/patio

16. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (35 reviews)
"Wonderful stay in the center of it all "
United States
lori
The price is ￥27,325
￥31,149 total
includes taxes & fees
Jul 27 - Jul 28
Fortaleza Charme House
Free daily buffet breakfast

17. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
9.4 out of 10, Exceptional, (9 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
The price is ￥17,443
￥19,886 total
includes taxes & fees
Jul 20 - Jul 21
San Nicola Rooms Siracusa
Exclusive Room | In-room safe, soundproofing, iron/ironing board (on request)

18. Isonzo Suites

Isonzo Suites
Santa Lucia
8.8 out of 10, Excellent, (6 reviews)
"."
Italy
Gianluca
The price is ￥12,476
￥19,729 total
includes taxes & fees
Aug 2 - Aug 3
Isonzo Suites
Double Room | Premium bedding, desk, cribs (surcharge), rollaway beds (surcharge)

19. B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (60 reviews)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is ￥13,831
￥15,768 total
includes taxes & fees
Jul 21 - Jul 22
B&B Siracusa
Luxury Quadruple Room, Balcony, City View | In-room safe, desk, soundproofing, iron/ironing board

20. B&B IL MORO

B&B IL MORO
Santa Lucia
The price is ￥10,299
￥15,977 total
includes taxes & fees
Jul 24 - Jul 25
B&B IL MORO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Lucia

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Breakfast area
Giuggiulena Villa
3.0 star property
10.0
Exceptional
130 reviews
View
Rooftop terrace
Caportigia Boutique Hotel
5.0 star property
9.4
Exceptional
288 reviews
View
Suite, Balcony, Sea View | Minibar, in-room safe, desk, soundproofing
Lakkios
3.0 star property
9.2
Wonderful
74 reviews
View
Coffee/tea maker, electric kettle
Nostos rooms & Apartments
3.0 star property
9.0
Wonderful
282 reviews
View
Suite | Soundproofing, WiFi (free)
Hotel Palazzo Cavalieri
4.0 star property
9.0
Wonderful
43 reviews
View

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

A natural rock arch over a body of water with people paddling in kayaks.

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Staff was excellent. Loved it."
Gerald 4-night trip
Posted 5 hours ago
Algila' Ortigia Charme Hotel

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.
Where is the best place to stay in Santa Lucia?
Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Caportigia Boutique Hotel and Fortaleza Charme House.
How many hotels can I expect to find in Santa Lucia?
Expedia has 310 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.
Where can I learn more about changing or cancelling my trip to Santa Lucia?
For more details about changing or cancelling your trip to Santa Lucia, click here.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia