A tropical island with a beach, clear turquoise waters, and lush greenery.

Find hotels in Santa Isabel from ￥31,896

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 8 - Sep 9
Tomorrow
Sep 9 - Sep 10
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Filter by

Property class

Guest rating

Our top choices for Santa Isabel hotels

Economy Bungalow
Economy Bungalow
Exterior
Exterior

1. Trips Guna Yala

Trips Guna Yala
Narganá
￥14,073
￥35,009 total
includes taxes & fees
Sep 30 - Oct 1
Trips Guna Yala
Property grounds
Panoramic Cabin, Ocean View
Basic Shared Dormitory
Panoramic Cabin, Ocean View

2. Cabins on paradise San Blas island

Cabins on paradise San Blas island
Narganá
￥41,482
￥45,630 total
includes taxes & fees
Sep 10 - Sep 11
Cabins on paradise San Blas island
Exterior
Breakfast area
Interior
Double Room, Sea View

3. Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS
Narganá
￥290,082
￥321,613 total
includes taxes & fees
Oct 9 - Oct 10
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Aerial view
Panoramic Cabin, Ocean View | Bathroom
Panoramic Cabin, Ocean View | Beach/ocean view
Panoramic Cabin, Ocean View

4. Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island
Narganá
United States
Ryan
￥28,996
￥31,896 total
includes taxes & fees
Sep 10 - Sep 11
Private Ocean-Front Cabin with private bathroom on San Blas Island
Luxury House, Lanai, Sea View | Private kitchen
Luxury House, Lanai, Sea View | Bathroom
Luxury House, Lanai, Sea View
Pool

5. Casa frente al mar - turtle cay marina

Casa frente al mar - turtle cay marina
Nombre de Dios
￥82,409
￥96,816 total
includes taxes & fees
Sep 17 - Sep 18
Casa frente al mar - turtle cay marina
Basic Cabin, Beach View | Beach
Front of property
Front of property
Front of property

6. Cabins in Chichime Island

Cabins in Chichime Island
Narganá
France
Anonymous traveler
￥24,695
￥27,164 total
includes taxes & fees
Oct 6 - Oct 7
Cabins in Chichime Island
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Santa Isabel

Explore pristine beaches along Santa Isabel's coastline where local fishermen can take you to nearby coral reefs for snorkeling. Hike through lush rainforest trails to spot colorful birds, then visit the town's central plaza where vendors sell fresh tropical fruits and handcrafted souvenirs.

See all hotels in Santa Isabel
A tropical island with a beach, clear turquoise waters, and lush greenery.

Top Santa Isabel Hotel Reviews

Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand

10/10 Excellent
"the view is beautiful! We were taken care of well."
Mirelys 5-night trip
Posted 2 months ago
Caribbean getaway: beach cottage just on the sand
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

10/10 Excellent
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door. "
Ryan 4-night trip
Posted 6 months ago
Private Ocean-Front Cabin with private bathroom on San Blas Island
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent
"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "
Dennis Or Trish H. 6-night trip
Posted 9 months ago
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

More cheap stays in Santa Isabel

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala
￥28,996
￥31,896 total
Sep 10 - Sep 11
includes taxes & fees
10/10 Exceptional! (1 review)
Private Ocean-Front Cabin with private bathroom on San Blas Island
Trips Guna Yala

Trips Guna Yala

Urgandi, Mamardub Narganá Guna Yala
￥14,073
￥35,009 total
Sep 30 - Oct 1
includes taxes & fees
Trips Guna Yala
Cabins on paradise San Blas island

Cabins on paradise San Blas island

9.587566, -78.879820 Narganá San Blas
￥41,482
￥45,630 total
Sep 10 - Sep 11
includes taxes & fees
Cabins on paradise San Blas island
Private wood Cabins on San Blas island - private bathroom

Private wood Cabins on San Blas island - private bathroom

Wailidup Island Narganá Guna Yala
Get ratesPrivate wood Cabins on San Blas island - private bathroom
Paradise Over the Water Cabins in San Blas

Paradise Over the Water Cabins in San Blas

G4V2 48 Narganá Guna Yala
Get rates
6/10 (1 review)
Paradise Over the Water Cabins in San Blas
Hotel El Porvenir

Hotel El Porvenir

Isla Porvenir Narganá Guna Yala
Get ratesHotel El Porvenir

Frequently asked questions

What's the best place to stay in Santa Isabel?
Located 17 mi (27.3 km) from the heart of Santa Isabel, Cocoloco - Catamaran Lagoon 52F SAN BLAS is a top choice for your stay based on our traveler data. Two other choices for your visit to the area are Private Ocean-Front Cabin with private bathroom on San Blas Island and Private wood Cabins on San Blas island - private bathroom. See all available top hotels, or vacation rentals in Santa Isabel.
What are some of the best vacation home rentals that Santa Isabel has to offer?
Casa frente al mar - turtle cay marina: This vacation home rental outside Santa Isabel is located in the suburbs and has a terrace, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a stovetop, a microwave, and kitchenware. See all vacation rentals in Santa Isabel.
If I need to cancel my hotel reservation in Santa Isabel, will I receive a refund?
Yes! The majority of room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Isabel.
Where can I learn more about changing or cancelling my trip to Santa Isabel?
For additional details about rescheduling or cancelling your trip to Santa Isabel, go to https://www.expedia.com/service/.
What's the best place to stay near Tocumen International Airport (PTY)?
Crowne Plaza Panama Airport is a popular 4-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.4 km) from Tocumen Intl. Airport. Other good options within close proximity to the airport include Riande Aeropuerto Hotel & Casino and Express Inn Panama International Airport Hostel.
What is staying in Santa Isabel like?
Visitors can enjoy all that Santa Isabel has to offer including its parks. There are 40 hotels and other accommodations in the surrounding area. Find out more about Santa Isabel.
What are the top places to visit in Santa Isabel?
Places to visit in the wider area include Chagres National Park and Porvenir Museum. Check out what more to see and do in Expedia's Santa Isabel guide.
What's the seasonal weather like in Santa Isabel?
The hottest months are usually June and September with an average temp of 80°F, while the coldest months are February and March with an average of 78°F. The rainiest months in Santa Isabel are October, August, July, and November, with each month seeing an average of 12 inches of rainfall.

Explore a world of travel with Expedia