Top 10 Hotels in Santa Fe, FL from ￥8,400 - Competitive Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Fe

Pet friendly

Apartment

Pool

Condo

Hot tub

Family friendly

Cottage

Waterpark

Cabin

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Santa Fe hotels

1. Hampton Inn & Suites Alachua I-75

Alachua

Jasmine

￥16,529

￥18,594 total

includes taxes & fees

Sep 13 - Sep 14

2. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Tobias

￥15,626

￥17,579 total

includes taxes & fees

Oct 6 - Oct 7

3. La Quinta by Wyndham Gainesville

Gainesville

Riesha

￥14,907

￥16,771 total

includes taxes & fees

Sep 8 - Sep 9

4. Clarion Pointe Alachua - Gainesville Area

Alachua

YESSICA

￥9,141

￥11,066 total

includes taxes & fees

Sep 7 - Sep 8

Suite, Multiple Beds, Non Smoking, Balcony

5. Best Western Gateway Grand

Gainesville

Ammarica

￥13,213

￥14,865 total

includes taxes & fees

Sep 13 - Sep 14

Standard Room, 2 Double Beds | Bathroom sink

6. Royal Inn

Alachua

Alec

￥11,251

￥12,657 total

includes taxes & fees

Sep 7 - Sep 8

Standard Room, 2 Queen Beds, Non Smoking (Larger Room)

7. HOM Hotel Gainesville, SureStay Collection by Best Western

Gainesville

Benjamin

￥12,024

￥13,527 total

includes taxes & fees

Sep 13 - Sep 14

8. Quality Inn Alachua - Gainesville Area

Alachua

Courtney

￥11,874

￥13,358 total

includes taxes & fees

Sep 27 - Sep 28

9. Drury Inn & Suites Gainesville

Gainesville

James

￥16,406

￥18,456 total

includes taxes & fees

Sep 13 - Sep 14

10. High Springs Country Inn

High Springs

Antonio

￥9,532

￥10,724 total

includes taxes & fees

Sep 15 - Sep 16

Executive Suite, 1 King Bed, Non Smoking

11. Comfort Suites Gainesville near University

Gainesville

Gladys

￥13,270

￥14,929 total

includes taxes & fees

Oct 4 - Oct 5

12. Hyatt Place Gainesville Downtown

Downtown Gainesville

maria

￥15,313

￥17,227 total

includes taxes & fees

Sep 13 - Sep 14

13. BlueGem Motel

High Springs

REINIER

￥13,650

￥15,356 total

includes taxes & fees

Sep 15 - Sep 16

Suite, 1 King Bed with Sofa bed, Non Smoking (Not Pet Friendly)

Room, 2 Queen Beds, Non Smoking (Pet Friendly)

14. Comfort Inn Gainesville - University Area

Gainesville

Jyothi

￥11,841

￥14,200 total

includes taxes & fees

Sep 13 - Sep 14

Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed)

Suite, 1 King Bed, Accessible, Non Smoking (with Sofabed)

15. Best Western Waldo Inn and Suites

Waldo

Ana Laura

￥16,031

￥18,034 total

includes taxes & fees

Sep 7 - Sep 8

16. Holiday Inn Express Starke by IHG

Starke

John

￥16,095

￥17,865 total

includes taxes & fees

Oct 4 - Oct 5

17. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

Henry

￥13,548

￥15,242 total

includes taxes & fees

Sep 13 - Sep 14

18. Aloft by Marriott Gainesville University Area

Gainesville

Elizabeth H

￥17,032

￥19,162 total

includes taxes & fees

Sep 20 - Sep 21

19. Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville

Arleana

￥18,751

￥21,306 total

includes taxes & fees

Sep 10 - Sep 11

20. Super 8 by Wyndham Gainesville I-75 Hospital University Area

Gainesville

Williams

￥7,467

￥8,400 total

includes taxes & fees

Sep 13 - Sep 14

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Fe Hotel Reviews

Drury Inn & Suites Gainesville

10/10 Excellent

"Room was clean; great breakfast choices."

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"I am a Gator parent and went to my 1st night game. The hotels around the area were ridiculous pricey for even the low budget hotels. So, I took the risk and book this Holiday Day Inn ( to be honest I haven’t been in a Holiday Day for years. So I was very concerned). However this place was amazing. Only 29 mins away from campus. The room, bed, bed sheets, bathroom, and amenities were awesome. I would recommend this hotel for everyone to go."

La Quinta by Wyndham Gainesville

10/10 Excellent

"CLEAN, CLEAN, wonderful beds, loved it !"

More cheap stays in Santa Fe

Days Inn by Wyndham Gainesville Hospital/University Area

2649 Sw 13th St Gainesville FL

￥10,157

￥11,427 total

Sep 7 - Sep 8

includes taxes & fees

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

￥11,290

￥12,702 total

Sep 8 - Sep 9

includes taxes & fees

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

￥12,024

￥13,527 total

Sep 13 - Sep 14

includes taxes & fees

8.6/10 Excellent! (2,103 reviews)

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL

￥11,841

￥14,200 total

Sep 13 - Sep 14

includes taxes & fees

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL

￥11,874

￥14,237 total

Oct 1 - Oct 2

includes taxes & fees

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL

￥13,270

￥14,929 total

Oct 4 - Oct 5

includes taxes & fees

Frequently asked questions

What's the best place for a stay in Santa Fe?

Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Country Inn & Suites by Radisson, Gainesville, FL and Hotel Eleo at the University of Florida. See all available top hotels, or vacation rentals in Santa Fe.

What are some of the best vacation rentals in Santa Fe?

Underwater Home w/Game Room ~6 min to Stadium & DT: This vacation home rental outside of Santa Fe is located in the city center and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind. See all vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

Where can I learn more about changing or cancelling my trip to Santa Fe?

To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.

What is staying in Santa Fe like?

Travelers to Santa Fe will find plenty to explore and enjoy. There are 794 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.

What are the top places to visit in Santa Fe?

Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Ruth B. Kirby Gilchrist Blue Springs State Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.

What's the seasonal weather like in Santa Fe?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

Explore a world of travel with Expedia

Book Hotels in Santa Fe on Expedia.com

Find hotels in Santa Fe, FL from ￥8,400

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Santa Fe hotels

1. Hampton Inn & Suites Alachua I-75

2. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3. La Quinta by Wyndham Gainesville

4. Clarion Pointe Alachua - Gainesville Area

5. Best Western Gateway Grand

6. Royal Inn

7. HOM Hotel Gainesville, SureStay Collection by Best Western

8. Quality Inn Alachua - Gainesville Area

9. Drury Inn & Suites Gainesville

10. High Springs Country Inn

11. Comfort Suites Gainesville near University

12. Hyatt Place Gainesville Downtown

13. BlueGem Motel

14. Comfort Inn Gainesville - University Area

15. Best Western Waldo Inn and Suites

16. Holiday Inn Express Starke by IHG

17. Country Inn & Suites by Radisson, Gainesville, FL

18. Aloft by Marriott Gainesville University Area

19. Hotel Indigo Gainesville-Celebration Pointe by IHG

20. Super 8 by Wyndham Gainesville I-75 Hospital University Area

Top Santa Fe Hotel Reviews

Drury Inn & Suites Gainesville

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

La Quinta by Wyndham Gainesville

More cheap stays in Santa Fe

Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville University I-75

HOM Hotel Gainesville, SureStay Collection by Best Western

Comfort Inn Gainesville - University Area

Sleep Inn & Suites University/Shands

Comfort Suites Gainesville near University

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app