Find Resorts & Hotels with Spas in San Luis Obispo, CA

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on San Luis Obispo Resorts & Hotels with Spas

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for San Luis Obispo hotels with a spa

Lobby
Oxford Suites Paso Robles

Oxford Suites Paso Robles

Oxford Suites Paso Robles
3.5 star property
Paso Robles
9.6 out of 10, Exceptional, (1661)
"This is our favorite hotel , location, clean and quiet "
United States
Laura
The price is ￥29,592
￥35,745 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Oxford Suites Paso Robles
Caveman | Bathroom | Shower, hair dryer, bathrobes, towels
Madonna Inn

Madonna Inn

Madonna Inn
3.5 star property
San Luis Obispo
9.2 out of 10, Wonderful, (1348)
"Always a great stay!! The pool, rooms, and steak house are amazing!!! "
United States
Ronald
The price is ￥21,148
￥29,314 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Madonna Inn
Property entrance
Avila Village Inn

Avila Village Inn

Avila Village Inn
3.5 star property
Avila Beach
9.2 out of 10, Wonderful, (1004)
"We really enjoyed our stay-room was clean-lobby was cozy and the entire place has tons of character!! "
United States
Alfredo
Avila Village Inn
Yoga
Allegretto Vineyard Resort Paso Robles

Allegretto Vineyard Resort Paso Robles

Allegretto Vineyard Resort Paso Robles
4.5 star property
River Oaks
9.6 out of 10, Exceptional, (1483)
"Beautiful place, well located"
Australia
Mario
The price is ￥38,837
￥44,546 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Allegretto Vineyard Resort Paso Robles
Restaurant
The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection
2.5 star property
Arroyo Grande
9.6 out of 10, Exceptional, (1004)
"The staff was very friendly, the breakfast was yummy, and the room was very clean. I would definitely stay here again."
United States
Vanessa
The price is ￥21,159
￥24,058 total
includes taxes & fees
Jan 2 - Jan 3, 2026
The Agrarian Hotel, BW Signature Collection
Outdoor pool
Sea Pines Resort

Sea Pines Resort

Sea Pines Resort
3.0 star property
Los Osos
8.2 out of 10, Very Good, (412)
"Nice staff."
United States
Ann
Sea Pines Resort
Reception
HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection
4.0 star property
Downtown San Luis Obispo
9.2 out of 10, Wonderful, (470)
"Excellent! So accommodating and eager to offer top notch service. Early check in, great referrals into town and spotless!"
United States
Melissa
The price is ￥35,698
￥45,927 total
includes taxes & fees
Jan 4 - Jan 5, 2026
HOTEL CERRO, Autograph Collection
Exterior
Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B
3.5 star property
Cayucos
9.8 out of 10, Exceptional, (198)
"Great place to stay"
United States
Jason
The price is ￥25,898
￥29,136 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Cayucos Sunset Inn B&B
Exterior
Dolphin Bay Resort & Spa

Dolphin Bay Resort & Spa

Dolphin Bay Resort & Spa
2.0 star property
Pismo Beach
The price is ￥65,572
￥75,080 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Dolphin Bay Resort & Spa
Suite, Private Bathroom, (CALIFORNIA KING PATIO - West) | City view
Inn at Rose's Landing

Inn at Rose's Landing

Inn at Rose's Landing
2.0 star property
Downtown Morro Bay
8.0 out of 10, Very Good, (1)
The price is ￥29,478
￥33,753 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Inn at Rose's Landing
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top San Luis Obispo Hotel Reviews

Madonna Inn

Madonna Inn

10/10 Excellent
"The room was amazing. The cave! So fun with the rock waterfall shower and bathroom sink."
Pam 1-night trip
Posted 2 days ago
Madonna Inn

Frequently asked questions

Looking for a spa hotel in San Luis Obispo?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers love the wineries and restaurants in San Luis Obispo. Enjoy the art galleries and beaches during your vacation. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday.
What is the best spa hotel in San Luis Obispo?
Madonna Inn is a top spa hotel featuring a fitness center, tennis courts, a bar, and an outdoor pool. Treat yourself to a facial, body scrub, or Swedish massage at the onsite spa. Other popular spa hotels in San Luis Obispo include Hotel San Luis Obispo and HOTEL CERRO, Autograph Collection.
How many spa hotels will I find in San Luis Obispo?
Among Expedia's 203 accommodation options in San Luis Obispo, there are 3 spa hotels.
What's there to see and do in San Luis Obispo?
Enjoy all that San Luis Obispo has to offer and visit Fremont Theater, Downtown SLO Farmers' Market, and Mission San Luis Obispo de Tolosa. If you have extra time while you're in the area, you might want to see Ah Louis Store and Cerro San Luis Obispo.
What is a San Luis Obispo spa hotel?
Spa hotels in San Luis Obispo provide lodging and have a full on-site spa which offers services like therapies and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.