Find hotels near Mayo Clinic Florida, Jacksonville from ￥18,588

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Our top choices for Mayo Clinic Florida hotels

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (447)
"Great facility to stay."
United States
Gary
The price is ￥27,919
￥31,688 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (91)
"Great place to stay"
United States
Judy
The price is ￥25,685
￥29,151 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hilton Jacksonville At Mayo Clinic
Terrace/patio
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (553)
"Very good hotel"
United States
Careli
The price is ￥17,781
￥20,182 total
includes taxes & fees
Jan 7 - Jan 8, 2026
TownePlace Suites by Marriott Jacksonville East
Terrace/patio
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1005)
"The room was super clean and the staff was excellent!"
United States
Angela
The price is ￥17,138
￥19,452 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1004)
"Good location for a family vacation "
United States
Angel
The price is ￥16,377
￥18,588 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very Good, (756)
"Great location "
United States
Josiah Christine
The price is ￥25,111
￥28,501 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
BBQ/picnic area
Salt Air Inn & Suites

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
7.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (415)
"Great stay , convenient locations , friendly staff and well priced "
United States
Grant
Salt Air Inn & Suites
Property amenity
TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (67)
"This was an awesome place to stay."
United States
Christine
The price is ￥18,093
￥20,535 total
includes taxes & fees
Jan 4 - Jan 5, 2026
TownePlace Suites by Marriott® Jacksonville Mayport
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1005)
"Great hotel"
United States
Nima
The price is ￥20,432
￥23,189 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Standard Room, 2 Queen Beds, Non Smoking | Down comforters, minibar, iron/ironing board, WiFi
The Hotel Palms

The Hotel Palms

The Hotel Palms
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
The price is ￥26,359
￥29,918 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Hotel Palms
Reception
Ponte Vedra Inn & Club

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (813)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
The price is ￥62,232
￥73,912 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Ponte Vedra Inn & Club
Beach/ocean view
The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (688)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
The price is ￥62,232
￥73,912 total
includes taxes & fees
Jan 3 - Jan 4, 2026
The Lodge and Club at Ponte Vedra Beach
Studio, 2 Queen Beds, Accessible, Non Smoking | Living area | 43-inch LCD TV with satellite channels, TV
Hampton Inn & Suites Jacksonville Deerwood Park

Hampton Inn & Suites Jacksonville Deerwood Park

Hampton Inn & Suites Jacksonville Deerwood Park
2.5 star property
Southside, 11.2 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (1001)
"Great stay"
United States
Mary Jean
The price is ￥17,777
￥20,178 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hampton Inn & Suites Jacksonville Deerwood Park
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1006)
"Breakfast was great. The selection was the best I have ever had in the US"
United States
Sandra
The price is ￥19,808
￥22,481 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hyatt Place Jacksonville / St. Johns Town Center
Exterior
Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
3.5 star property
Southside, 10.8 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1002)
"Very nice stay "
United States
Timmothy
The price is ￥17,781
￥20,182 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hotel Indigo Jacksonville-Deerwood Park by IHG
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3447)
"Nice stay!"
United States
Mark
The price is ￥20,916
￥23,739 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Margaritaville Jacksonville Beach
On the beach
Best Western Oceanfront

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1003)
"Great location, clean, comfortable bed, friendly staff"
United States
Jeff
The price is ￥19,214
￥21,808 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Oceanfront
Exterior
Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1000)
"Easy to walk to the beach and local restaurant"
United States
Allen D
The price is ￥27,763
￥31,511 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Four Points by Sheraton Jacksonville Beachfront
Free daily buffet breakfast
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1000)
"Staff is terrific and the room was very clean and comfortable."
United States
Gerri
The price is ￥17,937
￥20,359 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Holiday Inn Express Jacksonville Beach by IHG
On the beach, windsurfing
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (623)
"The room was great and the staff was exceptional. Would stay here again in a heartbeat. "
United States
Michael
The price is ￥25,735
￥29,210 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
"Friendly service, clean room"
Michael 6-night trip
Posted 17 hours ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Hotels near other Mayo Clinic Florida attractions

Adventure Landing

4.1/5 (157 reviews)
This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark.
See properties

Windsor Parke Golf Club

Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 43 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels will I find near Mayo Clinic Florida?
Expedia has 43 hotels and other accommodations within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?
To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.
What can I see and do near Mayo Clinic Florida?
You can enjoy live performances at Players by the Sea and Wilson Center For the Arts. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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