The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

A blue bridge over a river at sunset with a city skyline in the background.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic Florida hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

1. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Mercedes

￥23,982

￥27,220 total

includes taxes & fees

Sep 7 - Sep 8

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A modern kitchen with a bar area, seating, and a view of the outdoors.

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

￥21,730

￥24,663 total

includes taxes & fees

Aug 29 - Aug 30

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

3. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Tiffany

￥18,915

￥21,469 total

includes taxes & fees

Sep 6 - Sep 7

A lobby with a reception desk, seating area, and a staircase.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

Jorge

￥15,895

￥18,041 total

includes taxes & fees

Sep 20 - Sep 21

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

￥20,327

￥23,071 total

includes taxes & fees

Aug 28 - Aug 29

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Troy

￥24,160

￥27,422 total

includes taxes & fees

Aug 29 - Aug 30

A wooden deck leading to a picnic area with a table and benches, surrounded by a wooden fence and palm trees.

A living room with a grey sofa, wicker armchairs, a glass coffee table, a potted plant, and a wall art piece.

A backyard with a swimming pool, wooden deck, lounge chairs, and palm trees.

A bedroom with a bed, a nightstand, a lamp, a wicker chair, a coffee table, and a potted plant.

7. The Hotel Palms Poolside

7.8 km from Mayo Clinic Florida

Vinny

￥27,102

￥30,760 total

includes taxes & fees

Aug 25 - Aug 26

A hotel entrance with a covered walkway, palm trees, and a clear sign indicating a handicap-accessible entrance.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

A modern reception area with a reception desk, seating area, and a view of the outdoor space.

A modern dining area with wooden tables and red chairs, a coffee station, and a seating area with a blue accent wall.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Satish

￥20,346

￥23,093 total

includes taxes & fees

Aug 30 - Aug 31

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern hotel lobby with a long reception desk, seating area, and large windows.

A modern building entrance with a sign reading "element by Westin".

A modern conference room with a long table, several chairs, and pendant lighting.

9. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Tablo

￥24,160

￥27,422 total

includes taxes & fees

Sep 20 - Sep 21

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern living room with sofas, a coffee table, and a dining area.

A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.

10. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

Paul

￥22,730

￥25,798 total

includes taxes & fees

Aug 30 - Aug 31

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

11. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Yanique

￥17,485

￥19,846 total

includes taxes & fees

Sep 8 - Sep 9

A spacious lobby with a reception desk, seating area, and large windows.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

A bar area with wooden chairs, a round table, and a brick wall.

12. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

Brooke

￥20,131

￥22,445 total

includes taxes & fees

Aug 31 - Sep 1

A spacious lobby with a central seating area, large windows, and a fountain.

A spacious lobby with high ceilings, wooden beams, and a central chandelier.

A hotel room with two beds, a desk, a chair, a TV, and a view of the ocean.

13. Ponte Vedra Inn & Club

6.3 km from Mayo Clinic Florida

Michael

￥71,369

￥84,717 total

includes taxes & fees

Aug 30 - Aug 31

A pool with a waterfall feature, surrounded by large rock formations.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A hotel with a pool, a parking lot, and a view of the ocean.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

14. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Kevin

￥26,886

￥30,515 total

includes taxes & fees

Sep 7 - Sep 8

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A cafe with a tropical mural, a coffee menu, and a variety of seating options.

A modern building with multiple balconies overlooking a beach.

A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

15. Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

Noelia

￥23,723

￥26,926 total

includes taxes & fees

Aug 25 - Aug 26

An outdoor seating area with a fire feature, chairs, and a table.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A modern bar area with a counter, bar stools, and a television screen.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

16. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

stacy

￥20,187

￥22,913 total

includes taxes & fees

Sep 6 - Sep 7

An outdoor patio with seating, a fire pit, and string lights.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

17. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

David

￥21,458

￥24,355 total

includes taxes & fees

Sep 1 - Sep 2

A buffet with labeled containers of omelets and other dishes.

A hotel lobby with a reception desk, seating area, and a wall with a mountain mural.

A golf course with a water hazard and a bridge.

A modern office space with two desks, each with a computer monitor, keyboard, and chair.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Salvador

￥18,120

￥20,566 total

includes taxes & fees

Aug 30 - Aug 31

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern bar area with seating, a bar counter, and a view of the city through large windows.

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

19. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Alysha

￥28,452

￥32,293 total

includes taxes & fees

Aug 27 - Aug 28

A self-service beverage station with a refrigerated display and a coffee machine.

A snack display in a store with various chips and snacks.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

20. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Janet

￥17,402

￥19,752 total

includes taxes & fees

Aug 30 - Aug 31

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Star rating	Guest rating
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 330 reviews	View
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 587 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 653 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,028 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,008 reviews	View

Top Mayo Clinic Florida Hotel Reviews

TownePlace Suites by Marriott Jacksonville East

8/10 Good

"Only complaint is no decaf in the evening in the lobby."

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent

"Helpful staff"

Margaritaville Jacksonville Beach

10/10 Excellent

"The room was absolutely amazing!!! Beautiful view, spacious suite, and room service DAILY which is a plus in hotel’s today! The amenities were awesome and the onsite restaurant had excellent food! I highly recommend this hotel and will definitely be returning!"

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"This hotel is conveniently located, CLEAN, cool, comfortable. The rooms are spacious, well appointed and stocked. It's a nice area, a safe hotel with friendly, helpful staff, a good included breakfast, free parking, pet friendly and not outrageously priced considering the location. It is convenient to Jacksonville Beach and the Mayo Clinic! We would gladly stay here again!"

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent

"Really amazing breakfast! The drinks at the bar were good."

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent

"It was very clean and the staff was amazing even the housekeepers. The breakfast was amazing and the coffee was amazing as well. I will definitely stay again when I travel back to Florida. I will definitely recommend to friends and family."

Comfy Mayo Retreat: Pool & Close to Beach

10/10 Excellent

"Great location with a really nice park close by to walk the dogs. The pool was perfect!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

10/10 Excellent

"Cute, nicely decorated house in a quiet neighborhood but close to grocery and restaurants. Not far from the beach. Host was extremely helpful and responsive. Hope to stay here again soon."

Beach Retreat in Jacksonville: Pet/Family-Friendly

10/10 Excellent

"Our stay was great there was plenty of room for our group of 12. The house was clean and the pool was a huge hit."

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 45 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 45 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Explore a world of travel with Expedia

Flights to Jacksonville

Jacksonville Vacations

Car rentals near Jacksonville Naval Air Station

Find hotels near Mayo Clinic Florida, Jacksonville from ￥18,041

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Mayo Clinic Florida hotels

1. Hilton Jacksonville at Mayo Clinic near Beaches

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3. TownePlace Suites by Marriott Jacksonville East

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. The Hotel Palms Poolside

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. TownePlace Suites by Marriott® Jacksonville Mayport

11. Hyatt Studios Jacksonville/St Johns Town Center

12. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

13. Ponte Vedra Inn & Club

14. Hampton Inn Jacksonville Beach/Oceanfront

15. Margaritaville Jacksonville Beach

16. Hotel Indigo Jacksonville-Deerwood Park by IHG

17. Hyatt Place Jacksonville / St. Johns Town Center

18. Holiday Inn Express Jacksonville Beach by IHG

19. AC Hotel Jacksonville St Johns Town Center

20. Tru By Hilton Jacksonville St Johns Town Center

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

TownePlace Suites by Marriott Jacksonville East

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Margaritaville Jacksonville Beach

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hilton Jacksonville at Mayo Clinic near Beaches

Holiday Inn Express Jacksonville Beach by IHG

Comfy Mayo Retreat: Pool & Close to Beach

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Beach Retreat in Jacksonville: Pet/Family-Friendly

Frequently asked questions

Explore a world of travel with Expedia