Find hotels in Lyon, MS from ￥11,158

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Dec 4 - Dec 5
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Compare 33 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Lobby
Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale

2.5 star property
Clarksdale
6.0 out of 10, (403)
"Good location in town"
United States
Samuel
The price is ￥10,237
￥11,158 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Americas Best Value Inn & Suites Clarksdale
Front of property
Travelers Hotel

Travelers Hotel

2.5 star property
Clarksdale
9.8 out of 10, Exceptional, (275)
"Though a bit different, there was a great artsy feel to the hotel. "
United States
T
The price is ￥24,540
￥26,748 total
includes taxes & fees
Dec 6 - Dec 7
Travelers Hotel
Reception
Hampton Inn Clarksdale

Hampton Inn Clarksdale

2.5 star property
Clarksdale
8.2 out of 10, Very Good, (331)
"We would stay there again."
United States
Andrew Ray
The price is ￥20,334
￥22,165 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn Clarksdale
Lobby sitting area
Quality Inn

Quality Inn

2.5 star property
Clarksdale
7.4 out of 10, Good, (705)
"Room was great! Staff is always nice and sociable."
United States
LaVonda
The price is ￥12,395
￥13,510 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Quality Inn
Restaurant
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

2.0 star property
Clarksdale
9.6 out of 10, Exceptional, (89)
"great stay!"
United States
mary
Auberge Clarksdale Blues Hostel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lyon Hotel Reviews

Quality Inn

Quality Inn

10/10 Excellent
"The staff was professional and kind"
Cassandra is 1-night trip
Posted 5 days ago
Quality Inn

More cheap stays in Lyon

Quality Inn

Quality Inn

818 South State Street Clarksdale MS
The price is ￥12,395 per night from Jan 5 to Jan 6
￥12,395
￥13,510 total
Jan 5 - Jan 6, 2026
includes taxes & fees
7.2/10 Good! (704 reviews)

Frequently asked questions

What's the best place for a stay in Lyon?
Quality Inn, located 3.2 mi (5.2 km) from the heart of Lyon, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hampton Inn Clarksdale and Americas Best Value Inn & Suites Clarksdale. See all available top hotels, or vacation rentals in Lyon.
What are some of the best vacation rentals that Lyon has to offer?
Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS: This vacation home rental outside of Lyon offers a patio, a selection of books, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Lyon.
If I need to cancel my hotel reservation in Lyon, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Lyon.
Where can I learn more about changing or cancelling my trip to Lyon?
For additional details about updating your trip to Lyon or cancelling it, head over to our customer service page.
What is staying in Lyon like?
Travelers to Lyon will find plenty to explore and enjoy. There are 33 hotels and other accommodations in the surrounding area. Find out more about Lyon.
What should I do while I'm visiting Lyon?
Places to visit in the wider area include Delta Blues Museum, Red's Lounge, and Rock N' Roll & Blues Heritage Museum. You'll also find The Holy Moly Theatre and Hambone Art Gallery in the area. Check out what more to see and do in Expedia's Lyon guide.
What's the seasonal weather like in Lyon?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 47°F. The rainiest months in Lyon are April, March, May, and December, with each month seeing an average of 7 inches of rainfall.

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