A river with a bridge, a town, and a forested hillside.

Find Luxury Hotels in Hannibal, MO

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Check availability on Hannibal Luxury Hotels

Tonight
Sep 3 - Sep 4
Tomorrow
Sep 4 - Sep 5
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Hannibal luxury hotels

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.
A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.
A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.
A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

1. Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
￥28,498
￥32,872 total
includes taxes & fees
Sep 8 - Sep 9
Lighthouse Inn & Suites
View all properties

Top Hannibal Hotel Reviews

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

10/10 Excellent
"Staff was amazing. Not much breakfast but great for the price."
Betty 1-night trip
Posted 3 hours ago
Super 8 by Wyndham Hannibal
Best Western On The River

Best Western On The River

8/10 Good
"This hotel is very close to all the downtown attractions within walking distance. Very clean. We were looking forward to enjoying time in the hot tub in the evening but it broke down the day we arrived. We were very disappointed to say the least. The beds were very comfortable."
Mary 2-night trip
Posted 2 days ago
Best Western On The River

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Hannibal?
Use Expedia to arrange your flight to Quincy, IL (UIN-Quincy Regional-Baldwin Field) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Hannibal has to offer. During your visit, you might want to enjoy the museums which Hannibal is known for.
When can I expect good weather in Hannibal?
Planning for the weather is a good way to make your trip to Hannibal relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 34°F. Average annual precipitation for Hannibal is 47 inches.
What's there to see and do in Hannibal?
Take in some sights and attractions while you're in Hannibal by visiting Rockcliffe Mansion, Mark Twain Boyhood Home and Museum, and Mark Twain Memorial Lighthouse. If you have extra time while you're in the area, you might want to stop by Mark Twain Cave and Mississippi River.

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