A river with a bridge, a town, and a forested hillside.

Find Luxury Hotels in Hannibal, MO

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Hannibal Luxury Hotels

Tonight
Aug 28 - Aug 29
Tomorrow
Aug 29 - Aug 30
This weekend
Aug 28 - Aug 30
Next weekend
Sep 4 - Sep 6

Our top choices for Hannibal luxury hotels

Room
Superior Suite | Private kitchen
Jetted tub
Deluxe Suite | Living area

1. Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
￥28,586
￥32,974 total
includes taxes & fees
Sep 9 - Sep 10
Lighthouse Inn & Suites
View all properties

Top Hannibal Hotel Reviews

Best Western On The River

Best Western On The River

10/10 Excellent
"This was a great place. Very peaceful and clean."
Devin S 3-night trip
Posted 3 days ago
Best Western On The River
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

8/10 Good
"I would have given higher scores, Had I not discovered two cockroaches in my room and the ice makers wasn't working."
Rhonda 1-night trip
Posted 4 days ago
Super 8 by Wyndham Hannibal

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Hannibal?
Use Expedia to arrange your flight to Quincy, IL (UIN-Quincy Regional-Baldwin Field) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Hannibal has to offer. During your visit, you might want to enjoy the museums which Hannibal is known for.
When can I expect good weather in Hannibal?
Planning for the weather is a good way to make your trip to Hannibal relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 34°F. Average annual precipitation for Hannibal is 47 inches.
What's there to see and do in Hannibal?
Take in some sights and attractions while you're in Hannibal by visiting Rockcliffe Mansion, Big River Train Town, and Mark Twain Boyhood Home and Museum. If you have extra time while you're in the area, you might want to stop by Lovers Leap and Mark Twain Cave.

Explore a world of travel with Expedia