The Best Luxury Hotels in Hannibal, MO from ￥10,115 in 2026

If you're interested in literature/famous American authors, this might be the place for you! There are so many white sculptures of Twain it's unreal.

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Our top choices for Hannibal luxury hotels

Down comforters, blackout drapes, iron/ironing board, free WiFi

Lighthouse Inn & Suites

Hannibal

John

￥29,964 total

includes taxes & fees

Feb 12 - Feb 13

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Top Hannibal Hotel Reviews

Best Western On The River

10/10 Excellent

"We had an issue with our Expedia reservation. Tony was professional & provided excellent customer service fixing the issue. "

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Hannibal?

Use Expedia to arrange your flight to Quincy, IL (UIN-Quincy Regional-Baldwin Field) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Hannibal has to offer. During your visit, you might want to enjoy the museums which Hannibal is known for.

When can I expect good weather in Hannibal?

Planning for the weather is a good way to make your trip to Hannibal relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 34°F. Average annual precipitation for Hannibal is 47 inches.

What's there to see and do in Hannibal?

Take in some sights and attractions while you're in Hannibal by visiting Rockcliffe Mansion, Jim's Journey: The Huck Finn Freedom Center, and Mark Twain Boyhood Home and Museum. If you have extra time while you're in the area, you might want to stop by Mark Twain Memorial Lighthouse and Lovers Leap.