A river with a bridge, a town, and a forested hillside.

Find Luxury Hotels in Hannibal, MO

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Check availability on Hannibal Luxury Hotels

Tonight
Sep 1 - Sep 2
Tomorrow
Sep 2 - Sep 3
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Hannibal luxury hotels

Room
Superior Suite | Private kitchen
Jetted tub
Pool

1. Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
￥28,678
￥33,080 total
includes taxes & fees
Sep 2 - Sep 3
Lighthouse Inn & Suites
View all properties

Top Hannibal Hotel Reviews

Best Western On The River

Best Western On The River

8/10 Good
"Provided everything we needed for a couple days exploring Hannibal and extremely convenient location. Never had to use the car once we arrived. Just walked everywhere we needed to go. Room was clean and bed was comfortable."
Kevin 2-night trip
Posted 1 day ago
Best Western On The River
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

8/10 Good
"I would have given higher scores, Had I not discovered two cockroaches in my room and the ice makers wasn't working."
Rhonda 1-night trip
Posted 8 days ago
Super 8 by Wyndham Hannibal

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Hannibal?
Use Expedia to arrange your flight to Quincy, IL (UIN-Quincy Regional-Baldwin Field) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Hannibal has to offer. During your visit, you might want to enjoy the museums which Hannibal is known for.
When can I expect good weather in Hannibal?
Planning for the weather is a good way to make your trip to Hannibal relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 34°F. Average annual precipitation for Hannibal is 47 inches.
What's there to see and do in Hannibal?
Take in some sights and attractions while you're in Hannibal by visiting Rockcliffe Mansion, Mark Twain Boyhood Home and Museum, and Mark Twain Memorial Lighthouse. If you have extra time while you're in the area, you might want to stop by Mark Twain Cave and Mississippi River.

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