Find Luxury Hotels in Central Missouri, MO

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Central Missouri Luxury Hotels

Next weekend
In two weeks

Our top choices for Central Missouri luxury hotels

voco The Tiger Hotel Columbia, MO by IHG

voco The Tiger Hotel Columbia, MO by IHG
4.0 star property
Columbia
9.0 out of 10, Wonderful, (1000)
"Staff was extremely friendly and helpful. Room was spotless and comfortable. We ate at Glenns Cafe and it was amazing. "
United States
Pam
The price is ¥21,763
¥27,125 total
includes taxes & fees
Jan 2 - Jan 3, 2026
voco The Tiger Hotel Columbia, MO by IHG

DoubleTree by Hilton Hotel Jefferson City

DoubleTree by Hilton Hotel Jefferson City
4.0 star property
Jefferson City
8.4 out of 10, Very Good, (714)
"Safe parking, enjoyed the sapphire restaurant at the hotel."
United States
Kathy
The price is ¥18,488
¥21,232 total
includes taxes & fees
Jan 4 - Jan 5, 2026
DoubleTree by Hilton Hotel Jefferson City

Camden on the Lake Resort & Spa

Camden on the Lake Resort & Spa
4.0 star property
Lake Ozark
9.0 out of 10, Wonderful, (1001)
"Awesome staff, great food and service!!"
United States
Lori
Camden on the Lake Resort & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa
4.0 star property
Lake Ozark
7.4 out of 10, Good, (1087)
"Great Stay"
United States
Karen
The price is ¥12,064
¥16,770 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Lodge Of Four Seasons Golf Resort, Marina & Spa

The Broadway Columbia - a DoubleTree by Hilton

The Broadway Columbia - a DoubleTree by Hilton
4.0 star property
Columbia
9.4 out of 10, Exceptional, (945)
"Clean & great staff"
United States
ashley
The price is ¥20,414
¥23,164 total
includes taxes & fees
Jan 16 - Jan 17, 2026
The Broadway Columbia - a DoubleTree by Hilton

Boonville Luxury Lodging

Boonville Luxury Lodging
4.0 star property
Boonville
10.0 out of 10, Exceptional, (40)
"Everything is absolutely fantastic!"
United States
Rita
Boonville Luxury Lodging

Walnut Waters Bed & Breakfast

Walnut Waters Bed & Breakfast
4.0 star property
Lone Jack
10.0 out of 10, Exceptional, (10)
"Wonderful place to stay"
United States
Mitch
The price is ¥51,009
¥54,886 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Walnut Waters Bed & Breakfast

Hermann Hill

Hermann Hill
4.0 star property
Hermann
9.4 out of 10, Exceptional, (110)
"Top notch they think of everything. Highly recommend. "
United States
Kevin
The price is ¥47,362
¥54,455 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hermann Hill

Up Up and Away Lodging

Up Up and Away Lodging
4.0 star property
Hermann
9.4 out of 10, Exceptional, (27)
"Yes! The room was beautiful. Very clean. Beth was an amazing hostess, and the breakfast hit the spot. I highly recommend the stay, and when I return, I will do the same B&B. Thanks, Beth!"
United States
Brent
Up Up and Away Lodging

The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
4.5 star property
Hermann
9.8 out of 10, Exceptional, (28)
"Great place, fully stocked and clean!"
United States
Lauren
The price is ¥33,558
¥36,067 total
includes taxes & fees
Dec 30 - Dec 31
The Mercantile on the Katy Trail
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Central Missouri Hotel Reviews

Explore a world of travel with Expedia