Find 5 Star Hotels in Cape Cod, MA from ¥20,424
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Cape Cod 5 Star Hotels
Our top choices for Cape Cod 5-star hotels

9.4 out of 10, Exceptional, (243)
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Cape Cod.

Margaritaville Resort Cape Cod
1225 Iyannough Rd Hyannis MA
The price is ¥22,580 per night from Jan 4 to Jan 5
¥22,580
¥34,803 total
Jan 4 - Jan 5, 2026
includes taxes & fees
8.6/10 Excellent! (418 reviews)
Still don't see what you're looking for?
See all properties in Cape Cod.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Cape Cod
Windswept beaches and charming seaside towns await along this hook-shaped peninsula. Bike the Cape Cod Rail Trail, explore Provincetown's art galleries, or take a whale-watching tour from Hyannis Harbor.

Top Cape Cod Hotel Reviews

Wequassett Resort and Golf Club
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Riads in Harwich Port
- Town Houses in Hyannis Port
- Katama Hotels
- Cheap Hotels in Barnstable County
- Hotels near Ocean Edge Golf Club
- Inns in Cape Cod
- Historic Hotels in Onset
- Beach Hotels in Cape Cod
- Harwich Port Hotels
- Hotels near Woods Hole Science Aquarium
- Capsule Hotels in Provincetown
- Cheap Hotels in Cape Cod
- Aparthotels in Dennis Port
- Inns in Buzzards Bay
- Resorts in Sagamore Beach
- Resorts in Nantucket Island
- Luxury Hotels in Hyannis Port
- Pet-Friendly Hotels in Hyannis
- B&B in Oak Bluffs
- Inns in Woods Hole
- Vacation Homes in Cape Cod
- Hotels near Martha's Vineyard Film Center
- Inns in Hyannis Port
- Historic Hotels in Nantucket Island
- Eastham Hotels
- Hotels near Cape Cod Canal
- Cheap Hotels in Nantucket Island
- Condo Rentals in Eastham
- Resorts in Brewster
- Truro Hotels
- Castles in Dennis Port
- Falmouth Hotels
- Hotels near Rail Trail Bike Shop
- Country Houses in Cape Cod
- Cheap Hotels in Dennis Port
- Hotels near Marconi Beach
- Hostels in Cape Cod
- Hotels near Cape Cod Beaches
- Vineyard Haven Hotels
- B&B in Cape Cod
- Resorts in Cape Cod
- Town Houses in Provincetown
- Luxury Hotels in Hyannis
- Aparthotels in Manomet
- Hotels with a Pool in Centerville
- Boutique Hotels in Barnstable
- Apartments in Cape Cod
- Gay friendly Hotels in Provincetown
- Hotels near Cape Codder Water Park
- Chatham Hotels
- Beach Hotels in Katama
- Pet-Friendly Hotels in Barnstable
- Vacation Homes in Chatham
- Farmstay in Cape Cod
- Golf Hotels in Cape Cod
- Hotels near Water Wizz
- Green Hotels in Brewster
- Inns in Orleans
- Guest Houses in Sandwich
- Riads in Provincetown
- Hostels in Hyannis
- All-Inclusive Hotel Hotels in Sagamore Beach
- B&B in Hyannis
- Hotels near South Cape Beach State Park
- Resorts & Hotels with Spas in Sagamore
- Brewster Hotels
- Hotel with a Concierge Hotels in Nantucket Island
- Hotels near Seagull Beach
- Campground Landing Hotels
- Cheap Hotels in Provincetown
- Hyannis Hotels
- Woods Hole Hotels
- Orleans Hotels
- Aparthotels in Cape Cod
- Resorts in Manomet
- Hotels near Cape Cod Inflatable Park
- Holiday Park Resorts in Oak Bluffs
- Winery Hotels in Vineyard Haven
- Farmstay in East Sandwich
- Cheap Hotels in Hyannis
- Boutique Hotels in Brewster
- B&B in Woods Hole
- Guest Houses in Cape Cod
- Inns in Bourne
- Provincetown Hotels
- Hotels near Manomet Beach
- Town Houses in Marstons Mills
- Resorts in Sagamore
- Rv Parks in Cape Cod
- Hotels near Cape Cod Melody Tent
- Inns in Nantucket Island
- Hotels near Island Queen Ferry
- Sandwich Hotels
- Cheap Hotels in Chatham





