Find 5 Star Hotels in Big Pine Key, FL from ￥21,772

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Check availability on Big Pine Key 5 Star Hotels

Compare Big Pine Key 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Isla Bella Beach Resort & Spa
Property grounds

Isla Bella Beach Resort & Spa

5.0 star property
9.2 out of 10, Wonderful, (1045)
"Sea view, amazing staff , beautiful rooms "
The price is ￥34,424
￥47,531 total
includes taxes & fees
Sep 14 - Sep 15
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon, FL
The price is ￥35,333 per night from Oct 14 to Oct 15
￥35,333
￥49,283 total
Oct 14 - Oct 15
includes taxes & fees
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Enjoy a scrumptious seafood platter or venture out to sea to try to catch your own meal in one of the Florida Keys’ most relaxed communities.

See all hotels in Big Pine Key
Big Pine Key featuring a river or creek, a bay or harbor and general coastal views

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"This resort is absolutely lovely. Our room was perfect. The pools and beach bar were also great. The views from anywhere were picture perfect. One thing that was not great was the beach access into the water. You couldn't walk in because it was too rocky. "
Lynn 2-night trip
Posted 3 days ago
Isla Bella Beach Resort & Spa

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
You'll find a variety of pricing options for 5-star hotels in Big Pine Key on Expedia. The amount you pay will depend on when you want to travel, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to find the ideal high-end stay.

  • Search for the lowest price per night from ￥21,772

What makes a hotel 5 stars in Big Pine Key?
Flawless guest service characterizes every 5-star hotel in Big Pine Key. From the moment you enter the lobby, staff attend to your every whim, whether recommending activities or providing a turn-down service. Also, hotels have to offer superior conveniences to obtain a 5-star rating. These can include luxury bath products, saunas or spas, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find an upscale retreat in Big Pine Key where most of what you need is included. Next, narrow your results for properties that have 5 stars and are described as "All inclusive." The most important thing on the agenda at these stays? Pure enjoyment and indulgence.