Photo by Luis Urquia
Find 4 Star Hotels in Big Pine Key, FL from ￥56,299
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Big Pine Key 4 Star Hotels
Our top choices for Big Pine Key 4-star hotels
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Faro Blanco Resort & Yacht Club Marathon, Curio by HiltonMarathon
8.8 out of 10, Excellent, (1275)
"Room was spotless, staff was so sweet and helpful when we had questions. Would stay here again !"
Theresa
The price is ￥44,807
￥56,299 total
includes taxes & fees
Jan 5 - Jan 6, 2026
8.8 out of 10, Excellent, (1006)
"Great resort with lots of fun things to do. Really enjoyed our stay there. Would highly recommend it."
Jaskaran
The price is ￥50,588
￥67,169 total
includes taxes & fees
Jan 7 - Jan 8, 2026
10.0 out of 10, Exceptional, (1)
9.4 out of 10, Exceptional, (8)
"The Reef was a great place to stay. The Villa was wonderful. The pool was great. Staff very friendly. I highly recommend this place. "
Cynthia
Palm View 5 BR Pool, Dock KCB, Cabana Club, Outdoor Kitchen
Palm View 5 BR Pool, Dock KCB, Cabana Club, Outdoor KitchenKey Colony Beach
10.0 out of 10, Exceptional, (4)
"We loved this property. The boat dock is so large and we really appreciate the bumpers to protect the boat. Plenty of seating around the pool. The afternoon sun really heats that side of the street so the pool was very warm - still refreshing. The beds are super comfortable and the house is laid out very well with plenty of room. We loved our stay!!!"
Rachel T.
3-bedroom house in Lower Keys with Hot Tub, Sleeps 10+, Pet Freindly
3-bedroom house in Lower Keys with Hot Tub, Sleeps 10+, Pet FreindlyPine Channel Estates
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Indigo Reef Marina Homes Close to Boat Slip by Pack and RelaxMarathon Shores
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa
1 Knights Key Boulevard Marathon FL
The price is ￥48,294 per night from Jan 4 to Jan 5
￥48,294
￥64,238 total
Jan 4 - Jan 5, 2026
includes taxes & fees
9/10 Wonderful! (1,068 reviews)
Still don't see what you're looking for?
See all properties in Big Pine Key.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Big Pine Key
Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.
Top Big Pine Key Hotel Reviews
Tranquility Bay Beachfront Hotel and Resort
10/10 Excellent
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
10/10 Excellent