Top 10 Hotels in Panacea, FL from ￥16,452 - Competitive Prices

A coastal resort with beachfront villas and a clear blue sky.

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Our top choices for Panacea hotels

A pink door with a window, set in a corrugated metal exterior with wooden trim.

A bedroom with a bed, a bench, a wooden wardrobe, and a wall with starfish and a framed picture.

A wooden bench in a natural setting with trees and a body of water in the background.

A kitchen with a wooden countertop, a built-in sink, and a trash can.

1. The Panacea Motel

Panacea

Dashawn

￥17,541

￥19,559 total

includes taxes & fees

Oct 15 - Oct 16

A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.

A hotel lobby with a coffee bar, seating area, and a clock on the wall.

A hotel with a covered patio, outdoor seating, and a central pathway leading to the entrance.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

2. Best Western Wakulla Inn & Suites

Crawfordville

James

￥18,364

￥20,476 total

includes taxes & fees

Oct 26 - Oct 27

A spacious indoor area with tiled flooring, multiple tables and chairs, a stone fireplace, and a glass door entrance.

A stone fireplace with a painting above it, wooden walls, a dining area with chairs, and a view of parked cars through large windows.

A hotel with a red facade, a covered entrance, and palm trees.

3. Wildwood Inn

Crawfordville

Shane

￥18,813

￥21,610 total

includes taxes & fees

Nov 5 - Nov 6

A spacious lobby with leather sofas, a coffee table, and a large window with arched frames.

A boat docked at a pier with passengers on board.

A courtyard with a central fountain, surrounded by well-maintained hedges and trees.

A spacious dining area with multiple tables and chairs, large windows, and hanging chandeliers.

4. The Lodge at Wakulla Springs

Crawfordville

Joy

￥15,570

￥17,361 total

includes taxes & fees

Oct 26 - Oct 27

A bar area with a long counter, stools, and a variety of bottles and glasses.

A resort with multiple tennis courts, a swimming pool, and a golf course.

A swimming pool with lounge chairs, palm trees, and a clear blue sky.

A multi-story hotel with a reflective water body in front, surrounded by greenery and a golf course.

5. St James Bay Golf & Pickleball Resort

Carrabelle

Richard

￥17,427

￥25,101 total

includes taxes & fees

Oct 13 - Oct 14

A marina with boats docked, a small building, and a clear sky.

A pool area with a table and chairs, a building with doors, and a palm tree.

A spacious room with a pool table, a billiards table, and a dining area with chairs and a table.

A spacious room with a pool table, a round dining table with chairs, and large windows offering a view of a body of water.

6. The Moorings Hotel and Marina

Carrabelle

Tina

￥25,429

￥28,099 total

includes taxes & fees

Oct 14 - Oct 15

A covered patio with a table and chairs, a wooden ceiling fan, and a view of the surrounding greenery.

A cozy living room with a sofa, a small table, and a ceiling fan.

A bedroom with a wooden four-poster bed, a ceiling fan, a bookshelf, and a wall-mounted lamp.

A yellow door with a window, a potted plant, a white wall-mounted light fixture, and a staircase with yellow curtains.

7. The Old Carrabelle Hotel

Carrabelle

Christy

￥14,802

￥16,356 total

includes taxes & fees

Oct 13 - Oct 14

A hotel room with two beds, a nightstand, a lamp, and a bathroom visible through an open door.

A motel with a row of rooms, a staircase, and a parking area.

A motel with a single-story structure, a covered parking area, and a palm tree in front.

A bathroom with a toilet, shower, and sink with a marble countertop.

8. Franklin Inn

Carrabelle

Nathan

￥14,888

￥16,452 total

includes taxes & fees

Oct 13 - Oct 14

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Stay near popular Panacea attractions

Alligator Point Beach

8.8/10 (10 reviews)

Escape to this pristine stretch of old coastal Florida with white sands and shallow, clear waters. Spot dolphins and sea turtles while enjoying the serenity of an undeveloped shoreline.

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Bald Point State Park

8.6/10 (20 reviews)

Where Ochlockonee Bay meets Apalachee Bay, this coastal park showcases diverse ecosystems from beaches to pine flatwoods. Spot migrating raptors and monarch butterflies while hiking through pristine natural habitats.

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Mashes Sand Beach

8.8/10 (3 reviews)

Mashes Sands Beach offers serene shallow waters and expansive sandbars perfect for peaceful exploration. Wade through the tea-colored Gulf waters while spotting hermit crabs and enjoying spectacular sunset views.

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Public Beach Access

Mashes Sands Beach features tranquil white-sand shores and shallow waters ideal for families. Wade in the gentle surf, cast a fishing line, or enjoy a peaceful picnic away from tourist crowds.

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Wilson Beach

Wilson Beach offers a serene Gulf Coast escape with pristine shores and gentle waves far from tourist crowds. Bring supplies and enjoy peaceful beachcombing along this unspoiled natural sanctuary.

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Silver Lake

Swim in crystal-clear waters along a pristine 250-foot white sand beach surrounded by longleaf pines. The mile-long interpretive trail offers peaceful wildlife encounters with bald eagles and turtles.

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Panacea Springs

Once a popular health resort, these historic mineral springs were believed to possess healing properties in the early 1900s. Explore the remnants of spa structures while imagining the therapeutic rituals of a bygone era.

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Alligator Harbor Aquatic Preserve

Explore the great outdoors at Alligator Harbor Aquatic Preserve, a lovely green space in Panacea. Stroll along the beaches in this relaxing area, or seek out the fishing spots.

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Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

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Top Panacea Hotel Reviews

The Best Beach-Front House “Get-A-Way” in Florida

10/10 Excellent

"Wonderful property! I was looking for a quiet, dog-friendly beach vacation rental and this was the perfect spot! Perfect for long beach walks and our dog had a blast on the beach…true water dog. Owners were very responsive and accommodating. Ate at Angelo’s and 10/10 recommend!The beach was literally in the back yard. It was so easy to just walk out back and go down to the water."

Cozy bayfront farmhouse!

10/10 Excellent

"This is our second time staying here. Nice and clean , we enjoy back screened in porch overlooking the bay!"

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

10/10 Excellent

"Great place to stay very peaceful and relaxing."

Great sunrise view from dining area and decks. Easy beach access.

10/10 Excellent

"Property is clean and in a great location for peace and quiet. We enjoyed meeting the host and I'm sure will book with them again."

Lighthouse- enjoy the water, bask in the view

10/10 Excellent

"A very remote location, laid back small community and very natural beaches."

Hideaway Beach Cottage on waterfront with amazing views.

10/10 Excellent

"Booking this stay was incredibly easy. Hosts are responsive and very accommodating. Price was great, especially considering that we thought the property was even better in person. Pictures truly don’t do it justice. The small town of Panacea is a breath of fresh air. Not your typical touristy beach town. We wanted to have a slow, low stim vacation with our young kids and that’s exactly what we got. There are still enough restaurants to choose from if you want to eat out every night in the town and even more within a 20 minute drive. If you want to stay in and cook, the kitchen has plenty of room and is stocked well. Large dining table with more than enough room. The living area large and comfy. We didn’t use the second bedroom beds because our kids are still in pack and plays. Two fit in the room just fine. The master bedroom mattress was genuinely one of the most comfortable beds I’ve slept in. Screened in porch was amazing to relax in and let in 0 bugs somehow. So impressed. Our absolute favorite part though was the yard and little beach on the bay. Our kids can’t stand to be inside and they played for HOURS in the good sized yard. We watched stingrays, fish, and birds in the bay. The only thing I’d tell people to consider is that the beach can be a drive. The closest beach, Mashes Sands, had almost no shoreline so you’ll need to drive \- 20 minutes for a beach. This didn’t bother us at all. There is virtually no traffic and tons of options."

Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

10/10 Excellent

"This was our third trip to this house for a week. Enjoyed everything.. you don't need anything."

Coastal Getaway on canal-steps to the beach

10/10 Excellent

"Awesome weekend staying at this location. We was within walking distance to the beach and fishing. Loved that it had a complete bathroom downstairs when we came in from fishing all day and night. Great communication with the host. Very prompt responding to questions. Will recommend to family and friends!!"

"Somewhere In The Sun" Beachfront Cottage - Old Florida Style Hideaway

10/10 Excellent

"Great beach bungalow. Pictures don’t do it justice. Much more spacious than we anticipated. Had everything we needed. Very cute and wonderful views of the beach. Area was great for us, quiet, private, not touristy at all. We saw so many stars at night, even saw the Milky Way the first night there. Definitely recommend if you are looking for that old school small Florida beach house vibe."

More cheap stays in Panacea

Franklin Inn

1589 US-98 Carrabelle FL

￥14,888

￥16,452 total

Oct 13 - Oct 14

includes taxes & fees

The Old Carrabelle Hotel

201 Tallahassee St Carrabelle FL

￥15,673

￥17,319 total

Oct 14 - Oct 15

includes taxes & fees

The Panacea Motel

1545 Coastal Hwy Panacea FL

￥17,541

￥19,559 total

Oct 15 - Oct 16

includes taxes & fees

Best Western Wakulla Inn & Suites

3292 Coastal Hwy 98 Crawfordville FL

￥18,364

￥20,476 total

Oct 26 - Oct 27

includes taxes & fees

8.8/10 Excellent! (1,002 reviews)

The Moorings Hotel and Marina

1000 Hwy 98 Carrabelle FL

￥25,429

￥28,099 total

Oct 14 - Oct 15

includes taxes & fees

8.6/10 Excellent! (54 reviews)

Cozy Waterfront 'island House' on Live Oak Island!

Crawfordville FL

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Frequently asked questions

Where is the best place to stay in Panacea?

Based on Expedia's traveler preferences, The Panacea Motel is a top place to stay in Panacea. Other good choices for your visit include Your Fall Escape: FSU Football & Scalloping and Lighthouse- enjoy the water, bask in the view. See all available top hotels, or vacation rentals in Panacea.

What's the top vacation rental in Panacea?

BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has an outdoor pool, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. Other favorite homes for rent in Panacea are Your Fall Escape: FSU Football & Scalloping and Coastal Getaway on canal-steps to the beach. See all vacation rentals in Panacea.

If I need to cancel my hotel reservation in Panacea, will I receive a refund?

Yes! Most hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.

Where can I learn more about changing or cancelling my trip to Panacea?

For more details about changing or cancelling your trip to Panacea, click here.

What's the best pet-friendly place to stay in Panacea?

The Panacea Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.

What are some accommodations with pools in Panacea?

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front: Offers complimentary wireless internet access, a pool, and kitchens. Another choice that offers an onsite pool is BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.. View all hotels with pools in Panacea.

What's the best hotel for staying near Tallahassee Regional Airport (TLH)?

Tallahassee Sun & Moon is one of the top choices for your stay and is a popular property, featuring free WiFi and free parking. It's located 3.5 mi (5.7 km) from Tallahassee Regional Airport. Other options close to the airport include Hampton Inn & Suites Tallahassee Capitol-University and Governors Inn.

What's it like to stay in Panacea?

Nature enthusiasts will enjoy exploring Panacea, and many visitors are sure to appreciate the beaches and seafood restaurants. The relaxing and tucked away setting also entices those visiting the city. In Panacea, there are 228 hotels and other accommodations to choose from. Find out more about Panacea.

What are the top places to visit in Panacea?

Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach, and Bald Point State Park. Dolphin watching is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your agenda are Wilson Beach and Public Beach Access. Check out what more to see and do in Expedia's Panacea guide.

What's the seasonal weather like in Panacea?

The hottest months are usually July and August with an average temp of 81°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Panacea are August, July, June, and September, with each month seeing an average of 8 inches of rainfall.

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Find hotels in Panacea, FL from ￥16,452

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Panacea

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Panacea hotels

1. The Panacea Motel

2. Best Western Wakulla Inn & Suites

3. Wildwood Inn

4. The Lodge at Wakulla Springs

5. St James Bay Golf & Pickleball Resort

6. The Moorings Hotel and Marina

7. The Old Carrabelle Hotel

8. Franklin Inn

Stay near popular Panacea attractions

Alligator Point Beach

Bald Point State Park

Mashes Sand Beach

Public Beach Access

Wilson Beach

Silver Lake

Panacea Springs

Alligator Harbor Aquatic Preserve

Learn more about Panacea

Top Panacea Hotel Reviews

The Best Beach-Front House “Get-A-Way” in Florida

Cozy bayfront farmhouse!

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

Great sunrise view from dining area and decks. Easy beach access.

Lighthouse- enjoy the water, bask in the view

Hideaway Beach Cottage on waterfront with amazing views.

Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

Coastal Getaway on canal-steps to the beach

"Somewhere In The Sun" Beachfront Cottage - Old Florida Style Hideaway

More cheap stays in Panacea

Franklin Inn

The Old Carrabelle Hotel

The Panacea Motel

Best Western Wakulla Inn & Suites

The Moorings Hotel and Marina

Cozy Waterfront 'island House' on Live Oak Island!

Frequently asked questions

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