Mesopotamia

Travel Guide

Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
The price is ¥7,911 per night from Apr 1 to Apr 2
¥7,911
¥7,911 total
Apr 1 - Apr 2
Stay at this hotel in Gualeguaychú. Enjoy free WiFi, a 24-hour front desk, and a business center. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.6/10 Good! (80 reviews)
Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible

Reviewed on Mar 20, 2026

O2 Hotel Gualeguaychú
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
The price is ¥17,931 per night from Apr 20 to Apr 21
¥17,931
¥17,931 total
Apr 20 - Apr 21
Stay at this hotel in Corrientes. Enjoy free breakfast, free WiFi, and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ...
8/10 Very Good! (4 reviews)
Boa infraestrutura, e localização!

Reviewed on Feb 4, 2026

Turismo Hotel Casino
Intersur Colon

Intersur Colon

3 out of 5
Av. Gdor. Quiros 185 Colón Entre Ríos
The price is ¥15,821 per night from Apr 14 to Apr 15
¥15,821
¥15,821 total
Apr 14 - Apr 15
Stay at this hotel in Colon. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Dr. Herminio J. Quiros Park and Termas De Colón are located ...
8/10 Very Good! (8 reviews)
Staff as friendly but room was very dirty, toilet had not been flushed, broken lamps and dirty napkins on the floor.

Reviewed on Mar 9, 2026

Intersur Colon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Complejo La Loma

Complejo La Loma

3 out of 5
Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos
Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ...
8.4/10 Very Good! (6 reviews)
Great self-contained suite!
Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on Sep 9, 2023

Complejo La Loma
Totoras Apart Federacion

Totoras Apart Federacion

2.5 out of 5
Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios
Stay at this aparthotel in Federacion. Enjoy free WiFi, free parking, and room service. Popular attractions Termas de Federacion and Termas Federacion Water ...
Totoras Apart Federacion
Donsuites Apart Hotel

Donsuites Apart Hotel

3 out of 5
La Rioja 442 Corrientes Corrientes
Stay at this aparthotel in Corrientes. Enjoy free breakfast, free WiFi, and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ...
Donsuites Apart Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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