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Top Romantic Upstate South Carolina Hotels

Relax on the shore of Lake Hartwell in our Fair Play retreat

Fair Play SC

34 min drive from Clemson University

Book a stay at this business-friendly vacation home in Fair Play. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Lake Hartwell and Glenn ...

9.8/10 Exceptional! (236 reviews)

Couples like: spa tub, fireplace

Travelers say...

"Everything was great."

Reviewed on Jan 10, 2026

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Seneca SC

22 min drive from Clemson University

Enjoy a stay at this romantic cabin, featuring a garden and in-room fireplaces for couples to enjoy.

9/10 Wonderful! (86 reviews)

"My advice would be to find a good cleaning company, provide new linens for each guest, you need to include internet issues with the original listing giving guest the opportunity to decide if they will settle, move the day bed from the master suite to either of the other rooms, find a decorator to ..."

Reviewed on May 26, 2026

Peaceful Oasis Convenient to Greenville!

Simpsonville SC

2 hours drive from Clemson University

Stay at this vacation home in Simpsonville. Enjoy a water park, a garden, and laundry facilities. Popular attractions Haywood Mall and Village Market East are ...

10/10 Exceptional! (115 reviews)

"Pet friendly"

Reviewed on May 24, 2026

See all 3,019 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.