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Top Luxury Central Iowa Hotels

Des Lux Hotel

800 Locust St Des Moines IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at Des Lux Hotel, where you can enjoy amenities like designer toiletries, flat-screen TVs, and more. Notable amenities include ...

9.8/10 Exceptional! (1,051 reviews)

Hotel is clean. Very interesting decor, but it’s located in the perfect part of Downtown. It advertised a continental breakfast and honestly it was much more than that. Eggs, bacon, sausage, potatoes, etc. it was great.

Reviewed on May 2, 2026

Sonesta Essential Des Moines

4755 Merle Hay Road Des Moines IA

1 hour drive from Iowa State University

Indulge yourself with upscale accommodations at Sonesta Essential Des Moines, where you'll enjoy amenities like premium channels and more.

7.4/10 Good! (1,003 reviews)

Staff were great- room was clean. Bed was comfy.

Reviewed on Apr 30, 2026

La Quinta Inn & Suites by Wyndham Des Moines West Clive

1390 Nw 118th St Clive IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at La Quinta Inn & Suites by Wyndham Des Moines West Clive, where you can enjoy amenities like plush bedding, HDTVs, and ...

8.8/10 Excellent! (1,002 reviews)

I really liked the Dove hair care products, breakfast was very good and the room was spacious & clean.

Reviewed on Apr 30, 2026

See all 1,615 properties in Central Iowa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.