Central Iowa Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury Central Iowa Hotels
Des Lux Hotel
800 Locust St Des Moines IA
- 1 hour drive from Iowa State University
Treat yourself to a luxury stay at Des Lux Hotel, where you can enjoy amenities like designer toiletries, flat-screen TVs, and more. Notable amenities include ...
9.8/10 Exceptional! (1,103 reviews)
"Quaintly beautiful, unique, comfortable"
Reviewed on Sep 24, 2026
Sonesta Essential Des Moines
4755 Merle Hay Road Des Moines IA
- 1 hour drive from Iowa State University
Indulge yourself with upscale accommodations at Sonesta Essential Des Moines, where you'll enjoy amenities like premium channels and more.
7.6/10 Good! (1,010 reviews)
"The hotel room was clean and checking in and out was a very smooth process."
Reviewed on Sep 24, 2026
La Quinta Inn & Suites by Wyndham Des Moines West Clive
1390 Nw 118th St Clive IA
- 1 hour drive from Iowa State University
Treat yourself to a luxury stay at La Quinta Inn & Suites by Wyndham Des Moines West Clive, where you can enjoy amenities like plush bedding, HDTVs, and ...
8.8/10 Excellent! (1,012 reviews)
"Room was clean. Got our rest. Quiet."
Reviewed on Sep 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
