Eastern Tennessee Luxury Vacations 2026

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Eastern Tennessee Hotels

Carnegie Hotel & Spa

1216 W State Of Franklin Rd Johnson City TN

2 hours drive from Great Smoky Mountains National Park

Treat yourself to upscale accommodations at Carnegie Hotel & Spa, where you'll enjoy amenities like premium channels and more. Notable amenities include a spa, ...

9.8/10 Exceptional! (1,446 reviews)

"Nice hotel with some historic charm. The staff was friendly and nice. Overall a nice place to stay, but unless you have something to do at the ETSU campus, it is too close to all of the students, the traffic and noise for my personal preference. The bar is great! The restaurant is adequate, but they ..."

Reviewed on Sep 23, 2026

THE TENNESSEAN Hotel

531 Henley Street Knoxville TN

55 min drive from Great Smoky Mountains National Park

Treat yourself to a luxury stay at THE TENNESSEAN Hotel, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. The restaurant, fitness ...

The Read House Hotel

107 West Martin Luther King Blvd Chattanooga TN

4 hours drive from Great Smoky Mountains National Park

Go for a luxurious stay at The Read House Hotel, where you can enjoy amenities like Champagne service, plush bedding, and more. The indoor pool, restaurant, ...

9.6/10 Exceptional! (2,594 reviews)

"The room exceeded expectations. It was clean, beautiful view of downtown. I also appreciated the modern amenities such as usb charger ports for my electronics, the refrigerator and coffee bar setup in the room. The history of the hotel with the perfect location downtown makes it a perfect choice. ..."

Reviewed on Sep 21, 2026

See all 27,650 properties in Eastern Tennessee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.