Southern Indiana Luxury Vacations 2026

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Top Luxury Southern Indiana Hotels

21c Museum Hotel Louisville

700 W Main Street Louisville KY

3 hours drive from Holiday World and Splashin' Safari

21c Museum Hotel Louisville is one of the Louisville luxury 4.5-star boutique properties where you can treat yourself to Champagne service, massage services, ...

9.4/10 Exceptional! (1,014 reviews)

"I loved how eclectic this hotel was. The museums and all of the artwork were amazing. The moving penguins kept us laughing. We had an issue with our truck and the Valet was so helpful. We loved our nightly nightcap. We will definitely stay here again, and recommend it to others."

Reviewed on Aug 8, 2026

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

1 hour drive from Holiday World and Splashin' Safari

Treat yourself to a luxury stay at West Baden Springs Hotel, where you can enjoy amenities like plush bedding, designer toiletries, and more. Deluxe amenities ...

The Brown Hotel

335 W Broadway Louisville KY

3 hours drive from Holiday World and Splashin' Safari

The Brown Hotel is a Louisville luxury 4.5-star boutique property where you can pamper yourself with Egyptian cotton sheets, plush bedding, and more. The restaurant, ...

9.4/10 Exceptional! (1,286 reviews)

"The restaurants and bar had outstanding service and delicious food. All hotel staff we encountered were friendly and helpful. The beautiful historic lobby is so nice to enjoy. The location is very convenient for The Palace."

Reviewed on Aug 7, 2026

See all 1,617 properties in Southern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.