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Top Luxury Western Illinois Hotels

Econo Lodge Quincy

224 N 36th Street Quincy IL

4 hours drive from OSF Saint Francis Medical Center

Pamper yourself with a luxe vacation at Econo Lodge Quincy.

7/10 Good! (1,003 reviews)

"I would never come back to this hole in the wall unprofessional nasty hotel. When I got there almost midnight just did 16 hours from work I fell straight to sleep. In the morning I woke up saw that the sheets was nasty, the pillows had hair on them light bulbs missing refrigerator didn’t work and ..."

Reviewed on Jul 12, 2026

Baymont by Wyndham Peoria

2002 West War Memorial Drive Peoria IL

8 min drive from OSF Saint Francis Medical Center

Treat yourself to upscale accommodations at Baymont by Wyndham Peoria, where you'll enjoy amenities like premium channels and more. Sought-after amenities include ...

6.6/10 (549 reviews)

"The hotel is nice, And they have very good attention to their customers"

Reviewed on Jul 10, 2026

Mark Twain Hotel

225 NE Adams Street Peoria IL

14 min walk from OSF Saint Francis Medical Center

Treat yourself to a luxury stay at Mark Twain Hotel, where you can enjoy amenities like premium channels, flat-screen TVs, and more.

See all 675 properties in Western Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.