Plan, book, travel with confidence
Better together
Save up to ￥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,001 reviews)

Property especially the carpet was not as clean as I would expect. Lamp was missing light bulb.

Reviewed on Mar 12, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

9/10 Wonderful! (1,000 reviews)

Everything was great

Reviewed on Mar 6, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,109 reviews)

Beautiful stay at a historic property

Reviewed on Mar 12, 2026

See all 4,857 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.