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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,005 reviews)

"never again!"

Reviewed on Jun 19, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

9/10 Wonderful! (1,002 reviews)

"This is a nice hotel, walkable to campus. However, they tried to ignore my Expedia rate and book me in at a considerably higher rate. What was worse, I had prepaid an Expedia deposit which they had no record of. I was able to show them my email as proof. They had no interest in solving this issue ..."

Reviewed on Jun 13, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,175 reviews)

"The pools and views were great! Would suggest adding some umbrellas to pool area- there was little to no shade. Staff was great, check-in was seamless, and all the servers were awesome! Property is definitely in need of major TLC, but otherwise stay was fine."

Reviewed on Jun 20, 2026

See all 5,149 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.