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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Pamper yourself with an extravagant stay at The Umstead Hotel and Spa, where you'll find deep soaking bathtubs and pillowtop beds. The spa, outdoor pool, and ...

9.4/10 Exceptional! (709 reviews)

Everything other than dinner in room. Hamburger was way over done, couldn't eat it

Reviewed on Nov 28, 2025

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Go for a luxurious stay at The Carolina Inn, a Destination by Hyatt Hotel, where you can enjoy amenities like pillowtop beds, premium channels, and more. Notable ...

9.6/10 Exceptional! (1,002 reviews)

Fantastic orher than extremely small room size, but still worth it.❤️

Reviewed on Nov 23, 2025

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

The Mayton is one of the Cary luxury 4-star boutique properties where you can pamper yourself with Champagne service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (710 reviews)

New showers, better noise machine in room, excellent front desk at check in

Reviewed on Nov 21, 2025

See all 4,658 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.