Photo by Southernmost Illinois Tourism Bureau

Plan, book, travel with confidence
Better together
Save up to ￥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Kid friendly Southwest Illinois Hotels

Country Inn & Suites by Radisson, Marion, IL

1306 Halfway Road Marion IL

43 min drive from Southern Illinois University

Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

8.4/10 Very Good! (1,009 reviews)

Room was nice and staff was friendly.

Reviewed on Dec 1, 2025

Drury Plaza Hotel Mt. Vernon

145 North 44th Street Mount Vernon IL

2 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.6/10 Exceptional! (1,559 reviews)

Everything was great. Clean rooms, great customer service from the front desk to the kitchen staff. We will stay here again!

Reviewed on Nov 29, 2025

Comfort Inn & Suites O'Fallon - St. Louis Area

116 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

6.6/10 (81 reviews)

Yes

Reviewed on Nov 24, 2025

See all 729 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.