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Top Adventure Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...

8.4/10 Very Good! (2,156 reviews)

"I usually stay at another hotel for my Mayo Clinic appointments and treatment but it was full so I booked at Kaylee Grand due to convenience. When I checked in, all seemed fine until we got to our room. The state of the bathroom was disgusting! Massive amounts of hair on the floor and in the bathtub. ..."

Reviewed on Jun 14, 2026

Willow Inn Suites Rochester

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our ...

7.4/10 Good! (1,000 reviews)

"Safe, clean, friendly and great price."

Reviewed on Apr 17, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG

220 S Broadway Rochester MN

6 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...

8.8/10 Excellent! (1,017 reviews)

"Great staff, location, and onsite bar/restaurant! Only dislike was the parking ramp system with the QR code."

Reviewed on Jun 9, 2026

See all 913 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.