Plan, book, travel with confidence
Better together
Save up to ￥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adventure Southeast Jacksonville Hotels

Delta Hotels by Marriott™ Jacksonville Deerwood

4700 Salisbury Rd Jacksonville FL

10 min drive from Mayo Clinic Florida

Book a stay at this business-friendly hotel in Jacksonville. Enjoy free parking, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful ...

8.4/10 Very Good! (511 reviews)

Clean, convenient, nice staff

Reviewed on Jan 18, 2026

Residence Inn by Marriott Jacksonville Butler Boulevard

10551 Deerwood Park Blvd Jacksonville FL

7 min drive from Mayo Clinic Florida

Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...

8.6/10 Excellent! (1,001 reviews)

room was clean. lobby area for the 100 building is worn, needs new carpeting and front door.

Reviewed on Jan 12, 2026

Marriott Jacksonville

4670 Salisbury Rd Jacksonville FL

10 min drive from Mayo Clinic Florida

Book a stay at this business-friendly hotel in Jacksonville. Enjoy free parking, breakfast (surcharge), and room service. Our guests praise the helpful staff ...

8.6/10 Excellent! (930 reviews)

Everything was great

Reviewed on Jan 14, 2026

See all 547 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.