Southeast Jacksonville Luxury Vacations 2026

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Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Pamper yourself with a luxe vacation at Tricove Inn & Suites. Notable amenities at this motel include an outdoor pool and a fitness center.

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Be treated to a luxury stay at Red Roof Inn PLUS+ Jacksonville - Southpoint, where you can enjoy amenities like premium channels, flat-screen TVs, and more. ...

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Choose luxury at Wyndham Garden Jacksonville, where you can enjoy amenities like memory foam beds, premium channels, and more. The outdoor pool, beach bar, and ...

7.8/10 Good! (2,062 reviews)

"No breakfast"

Reviewed on Sep 23, 2026

See all 607 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.