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Top Luxury Central Iowa Hotels

Des Lux Hotel

800 Locust St Des Moines IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at Des Lux Hotel, where you can enjoy amenities like designer toiletries, flat-screen TVs, and more. Notable amenities include ...

9.8/10 Exceptional! (1,072 reviews)

"Staff and room were exceptional in everyway!"

Reviewed on May 18, 2026

Sonesta Essential Des Moines

4755 Merle Hay Road Des Moines IA

1 hour drive from Iowa State University

Indulge yourself with upscale accommodations at Sonesta Essential Des Moines, where you'll enjoy amenities like premium channels and more.

7.4/10 Good! (1,009 reviews)

"There was no pool as stated, there is a hidden deposit fee, the rooms were way over priced and our stuff was stolen by the housekeepers"

Reviewed on May 18, 2026

La Quinta Inn & Suites by Wyndham Des Moines West Clive

1390 Nw 118th St Clive IA

1 hour drive from Iowa State University

Treat yourself to a luxury stay at La Quinta Inn & Suites by Wyndham Des Moines West Clive, where you can enjoy amenities like plush bedding, HDTVs, and ...

8.8/10 Excellent! (1,003 reviews)

"This was a very clean and well maintained hotel. It was quiet and the bed was comfortable. The breakfast was great! The staff at check in were a little grumpy and difficult to understand, but it didn't detract from my stay."

Reviewed on May 18, 2026

See all 1,607 properties in Central Iowa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.