Plan, book, travel with confidence
Better together
Save up to ￥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Northeast Ohio Hotels

InterContinental Cleveland by IHG

9801 Carnegie Ave Cleveland OH

4 min walk from Cleveland Clinic

Discover luxurious lodging at InterContinental Cleveland by IHG, where you can enjoy amenities like massage services, 24-hour room service, and more. Deluxe ...

9/10 Wonderful! (861 reviews)

By all means, stay at the club level.

Reviewed on Jan 13, 2026

The Ritz-Carlton, Cleveland

1515 West Third Street Cleveland OH

10 min drive from Cleveland Clinic

Discover luxurious lodging at The Ritz-Carlton, Cleveland, where you can enjoy amenities like 24-hour room service, plush bedding, and more. The restaurant, ...

8.8/10 Excellent! (276 reviews)

Clean, spacious rooms. Very helpful staff

Reviewed on Jan 17, 2026

Drury Plaza Hotel Cleveland Downtown

1380 East 6th Street Cleveland OH

9 min drive from Cleveland Clinic

Visit Drury Plaza Hotel Cleveland Downtown for a relaxing stay in Cleveland. Popular amenities include an indoor pool, a restaurant, and a fitness center.

9.4/10 Exceptional! (2,653 reviews)

Everything was lovely except the noise. Beautiful hotel, rooms were lovely and clean, but there’s a lot of echo off of tall marble walls. Because of the pool and great location, plus the breakfast and included drinks and snacks at the Kick Back each evening, it’s a family-friendly place. But that ...

Reviewed on Jan 19, 2026

See all 4,253 properties in Northeast Ohio

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.