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Top Luxury Panhandle Plains Hotels

Studio 6 Amarillo, TX – West Medical Center

6801 W Interstate 40 Amarillo TX

4 hours drive from Texas Tech University

Treat yourself to some luxurious accommodations at Studio 6 Amarillo, TX – West Medical Center, where you can enjoy amenities like pillowtop beds, designer toiletries, ...

7.4/10 Good! (1,000 reviews)

The room was absolutely amazing for the price. The bed was so comfortable that I actually overslept and didn't want to leave. I would have loved yo have been able to stay longer and make use of v the gym and the pool. Both looked great. If I am ever in Amarillo again I know where I will be staying. ...

Reviewed on Dec 19, 2025

Spark by Hilton Amarillo East

2301 East I40 Amarillo TX

4 hours drive from Texas Tech University

Indulge yourself with classy lodging with a stay at Spark by Hilton Amarillo East, where you'll enjoy amenities like premium bedding and more. Notable amenities ...

8.8/10 Excellent! (279 reviews)

The A/C was somewhat weak - however, we were able to open a window and the cool fresh air was a nice alternative.

Reviewed on Jan 14, 2026

Hawthorn Suites by Wyndham Lubbock

4435 Marsha Sharp Fwy Lubbock TX

25 min walk from Texas Tech University

Hawthorn Suites by Wyndham Lubbock provides luxe lodging where you'll enjoy pillowtop beds and more. The indoor pool, fitness center, and hot tub are just some ...

7.8/10 Good! (1,007 reviews)

Loved the breakfast. And enjoyed the room and its cleanlines

Reviewed on Jan 19, 2026

See all 2,268 properties in Panhandle Plains

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.