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Top Luxury Panhandle Plains Hotels

Studio 6 Amarillo, TX – West Medical Center

6801 W Interstate 40, Amarillo, TX

4 hours drive from Texas Tech University

Treat yourself to some luxurious accommodations at Studio 6 Amarillo, TX – West Medical Center, where you can enjoy amenities like pillowtop beds, designer toiletries, ...

7.4/10 Good! (1,012 reviews)

"This was only an overnight stay. But, it was way better than I expected, especially with the low cost. Room was clean, roomy and very comfortable. Staff was very friendly. Will definitely be my go to stop to and from Colorado."

Reviewed on Sep 24, 2025

Spark by Hilton Amarillo East

2301 East I40, Amarillo, TX

4 hours drive from Texas Tech University

Indulge yourself with classy lodging with a stay at Spark by Hilton Amarillo East, where you'll enjoy amenities like premium bedding and more. Notable amenities ...

8.6/10 Excellent! (126 reviews)

"Very nice, spacious room, well layed out. Nice Keurig coffee and tea maker. The ONLY thing we are not as happy with is the tiny refrigerator that is not very cold and no way to adjust it - need it for my medication and we were concerned it wasn’t cold enough so tried putting the room ice container ..."

Reviewed on Sep 28, 2025

Hawthorn Suites by Wyndham Lubbock

4435 Marsha Sharp Fwy, Lubbock, TX

25 min walk from Texas Tech University

Hawthorn Suites by Wyndham Lubbock provides luxe lodging where you'll enjoy pillowtop beds and more. The indoor pool, fitness center, and hot tub are just some ...

7.8/10 Good! (1,010 reviews)

"Clean and awesome staff. Fast and accommodating."

Reviewed on Sep 23, 2025

See all 2,136 properties in Panhandle Plains

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.