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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,008 reviews)

Room very clean, good breakfast, low price, only downside is the hallway carpet dated, not clean, otherwise would have been perfect.

Reviewed on May 8, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

9/10 Wonderful! (1,002 reviews)

Beautifully maintained properly with beautiful decorations. Everything was clean and tidy great restaurant choices nearby.

Reviewed on May 4, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,114 reviews)

Great

Reviewed on May 6, 2026

See all 5,067 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.