Central Missouri Luxury Vacations 2026

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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,001 reviews)

"Overall, not bad. The staff were helpful and friendly. The bed was comfortable. Cleanliness of the property was average. The microwave looked like it could use a little cleaning. The toilet was not flushing properly. The staff gave me a plunger, but it didn’t help much. What I found truly amazing ..."

Reviewed on Aug 29, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

See all 5,275 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.