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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

24 min walk from University of Missouri

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.4/10 Good! (1,001 reviews)

The front desk are awesome people

Reviewed on Jan 12, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

8 min walk from University of Missouri

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

8.8/10 Excellent! (1,000 reviews)

Clean room, amenities, location, good restaurant. However, the AC/heating unit was very very loud. It was hard for me to get a good nights sleep.

Reviewed on Jan 10, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

2 hours drive from University of Missouri

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,101 reviews)

Great check in person

Reviewed on Jan 14, 2026

See all 4,695 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.