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Top Luxury Florida Keys Hotels

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue Key West FL

10 min drive from Duval Street

Pamper yourself with a luxury stay at Oceans Edge Key West Resort, Hotel & Marina, where you can enjoy amenities like Egyptian cotton sheets, plush bedding, ...

9/10 Wonderful! (1,854 reviews)

Very relaxing

Reviewed on May 1, 2026

The Marker Key West Harbor Resort

200 William Street Key West FL

10 min walk from Duval Street

Be treated to a grand stay at The Marker Key West Harbor Resort, where you'll find deep soaking bathtubs and premium bedding. The 3 outdoor pools, poolside bar, ...

9.2/10 Wonderful! (1,000 reviews)

Perfect location, everything within a 10 min walk Very friendly and professional staff. Competitively priced breakfast. Wide range of drinks at the bar Will stay again the next time we visit Key Wedt

Reviewed on Apr 30, 2026

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Duval Street

Cheeca Lodge & Spa is a Islamorada luxury 5-star beach property where you can treat yourself to Champagne service, massage services, and more. The 2 poolside ...

9.2/10 Wonderful! (1,316 reviews)

What a fun place with lots of activities to be enjoyed including water activities, games and bikes. The staff were all so great and welcoming. Our room was a beach front bungalow with a screened in porch that was very enjoyable. There was a bug problem in our bed with small caterpillar creatures ...

Reviewed on May 1, 2026

See all 8,305 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.