Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Beach Southeast Jacksonville Hotels

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

13733 Beach Blvd Jacksonville FL

4 min drive from Mayo Clinic Florida

Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9/10 Wonderful! (1,002 reviews)

"Super comfy bed. Nice staff. Close to everything we need for a late night stay."

Reviewed on Jun 19, 2026

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Settle in and relax at this hotel and watch the sunset on the beach in Jacksonville, as you'll be not far from the beach. A beach bar, an outdoor pool, and a ...

8/10 Very Good! (1,918 reviews)

Travelers like: close to beach, beach bars, outdoor pool

Travelers say...

"Unfortunately, our experience was very disappointing. During our stay we encountered multiple cockroaches in the room, including inside the dresser drawers where our family’s clothing was stored. Traveling with a 16-month-old and a 6-year-old, we ended up staying awake until around 2:00 AM dealing ..."

Reviewed on Jun 21, 2026

Delta Hotels by Marriott™ Jacksonville Deerwood

4700 Salisbury Rd Jacksonville FL

10 min drive from Mayo Clinic Florida

Book a stay at this business-friendly hotel in Jacksonville. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful ...

8.4/10 Very Good! (649 reviews)

"Nice place"

Reviewed on Jun 19, 2026

See all 588 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.