Southeast Minnesota Adventure Vacations 2026

Photo by Sara Crotts

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adventure Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...

Willow Inn Suites Rochester

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our ...

6.8/10 (14 reviews)

"Found a bug on my curtain first night, they upgraded my room but pool was out of service (which I needed for physical therapy), no shutting to Mayo, no breakfast except 1 day they had bagels no cream cheese no butter. Using washing machine was a while kdchv"

Reviewed on Oct 3, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG

220 S Broadway Rochester MN

6 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...

See all 951 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.