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Top Adventure Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...

8.4/10 Very Good! (2,163 reviews)

"Check in was quick and efficient. Staff at desk and at valet were helpful. Valet gave directions to self park and very friendly and helpful. Room was good but bathroom was small and doorway entrance to the bathroom was very narrow. Pool area was bright and clean and very enjoyable. Excellent location ..."

Reviewed on Jun 26, 2026

Willow Inn Suites Rochester

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our ...

Hotel Indigo Rochester – Mayo Clinic Area by IHG

220 S Broadway Rochester MN

6 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...

8.8/10 Excellent! (1,002 reviews)

"This is a well located property, close to restaurants, shopping, and Mayo Clinic. The staff was very understanding of the fluidity of my stay due to appointments at Mayo Clinic. The property doesn't have some of the amenities of other more expensive hotels in the area, but it is a great value for ..."

Reviewed on Jun 25, 2026

See all 917 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.