The Best Luxury Hotels in Southern Indiana from ￥23,298 in 2026 | Expedia

A modern glass building with a curved facade and a sign reading "The Kentucky Center".

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Check availability on Southern Indiana Luxury Hotels

Tonight

Oct 19 - Oct 20

Tomorrow

Oct 20 - Oct 21

This weekend

Oct 23 - Oct 25

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Our top choices for Southern Indiana luxury hotels

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

1. The Brown Hotel

Downtown Louisville

Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.

￥19,800

￥23,298 total

includes taxes & fees

Oct 29 - Oct 30

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

2. 21c Museum Hotel Louisville

Downtown Louisville

Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.

￥24,043

￥29,079 total

includes taxes & fees

Nov 9 - Nov 10

A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.

A long table set with white tablecloths, gold chargers, and clear glassware.

A covered porch with a brick wall, a wooden door, and a hanging light fixture.

A marble countertop with a tray of colorful glassware, a bottle, and two glasses. A framed painting hangs above, and two lamps are on either side.

3. The Pepin Mansion Historic B&B

New Albany

￥13,265

￥14,990 total

includes taxes & fees

Oct 20 - Oct 21

A bedroom with a large bed, a wooden floor, a white door, and a painting on the wall.

A living room with a dining area, white cabinetry, a flat-screen TV, and a large patterned rug.

A cozy living room with a staircase, a sofa, a patterned rug, and a small table with a lamp.

A modern kitchen with a central island, wooden bar stools, a black refrigerator, and white cabinetry.

4. Eclectic & Unique Historic Home

New Albany

￥27,654

￥76,604 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with a table, chairs, and a lantern.

A traditional room with a sofa, armchairs, a coffee table, and a sideboard.

A grand staircase with dark wood railings and a chandelier.

A cozy porch area with wicker furniture, a ceiling fan, string lights, and a welcome sign.

5. Inn at Woodhaven

St. Matthews

￥37,735

￥43,800 total

includes taxes & fees

Nov 1 - Nov 2

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

6. Louisville Bourbon Inn

Old Louisville

Luxurious bourbon country retreat offers elegant rooms with Egyptian cotton sheets and champagne service just minutes from downtown.

￥44,087

￥51,172 total

includes taxes & fees

Oct 20 - Oct 21

A modern kitchen with white cabinetry, a large island with bar stools, and a wood floor.

A hot tub with a cover, surrounded by a garden with a paved area.

A bedroom with a bed, a ceiling fan, a TV, and a window with curtains.

A room with a foosball table, two ping pong tables, and a blue chair.

7. Creation Museum Hot Tub 4BR for 10

Burlington

￥42,805

￥87,867 total

includes taxes & fees

Oct 20 - Oct 21

View all properties

Top Southern Indiana Hotel Reviews

Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

8/10 Good

"Bed was clean and very comfortable. The toilet sat very low however, the bathroom was very clean. Breakfast bar was extremely good and well maintained and frequently stocked by the employees. Would recommend this facility."

Spark by Hilton Evansville East, IN

Spark by Hilton Evansville East, IN

8/10 Good

"nice place and affordable"

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