A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Tonight
Oct 12 - Oct 13
Tomorrow
Oct 13 - Oct 14
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Southern Indiana luxury hotels

A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

1. The Brown Hotel

The Brown Hotel
Downtown Louisville
  • Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.
￥19,837
￥23,341 total
includes taxes & fees
Oct 25 - Oct 26
The Brown Hotel
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A steam fountain in a brick alleyway.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

2. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.
￥24,085
￥29,130 total
includes taxes & fees
Nov 8 - Nov 9
21c Museum Hotel Louisville
A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.
A marble countertop with a tray of colorful glassware, a bottle, and two glasses. A framed painting hangs above, and two lamps are on either side.
A grand hallway with a wooden floor, a staircase, a chandelier, and a large mirror.
A long table set with white tablecloths, gold chargers, and clear glassware.

3. The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
New Albany
￥18,607
￥21,025 total
includes taxes & fees
Oct 29 - Oct 30
The Pepin Mansion Historic B&B
A bedroom with a large bed, a wooden floor, a white door, and a painting on the wall.
A dining area with a piano, a large woven pendant light, and a patterned rug.
A cozy living room with a staircase, a sofa, a patterned rug, and a small table with a lamp.
A living room with a dining area, white cabinetry, a flat-screen TV, and a large patterned rug.

4. Eclectic & Unique Historic Home

Eclectic & Unique Historic Home
New Albany
￥25,330
￥73,703 total
includes taxes & fees
Oct 14 - Oct 15
Eclectic & Unique Historic Home
A wooden deck with a table, chairs, and a lantern.
A grand staircase with dark wood railings and a chandelier.
A large, historic house with a green roof, multiple chimneys, and a prominent front porch.
A traditional room with a sofa, armchairs, a coffee table, and a sideboard.

5. Inn at Woodhaven

Inn at Woodhaven
St. Matthews
￥39,755
￥46,143 total
includes taxes & fees
Nov 1 - Nov 2
Inn at Woodhaven
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.
A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.
A living room with a sofa, armchair, coffee table, fireplace, and large windows.

6. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville
  • Luxurious bourbon country retreat offers elegant rooms with Egyptian cotton sheets and champagne service just minutes from downtown.
￥44,168
￥51,267 total
includes taxes & fees
Oct 19 - Oct 20
Louisville Bourbon Inn
View all properties

Top Southern Indiana Hotel Reviews

Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

10/10 Excellent
"Front desk girl could put a smile on anybody’s face"
Beth 1-night trip
Posted 1 day ago
Hampton Inn New Albany Louisville West
Spark by Hilton Evansville East, IN

Spark by Hilton Evansville East, IN

8/10 Good
"This was a nice property. Bed and pillows comfortable. Room acceptable. Good healthy breakfast options. First place I've stayed that had that kind of options available. (Yogurt, hard boiled eggs, fresh fruit. There were also muffins, bagels, oatmeal, cereal options) Negatives, I was not a fan of the sink area being as soon as you opened the door to the room. Trying to get ready and if door opened, you're exposed to the whole hallway. There is a fitness center. Has free weights, which was great. However, there's no bench to be able to use. Staff was acceptable, not overly friendly, but not ugly and mean. Just there doing their job. Overall, would definitely stay again."
Andrew 1-night trip
Posted 1 day ago
Spark by Hilton Evansville East, IN

Explore a world of travel with Expedia