The Best Luxury Hotels in Southern Indiana from ￥18,382 in 2026 | Expedia

A modern glass building with a curved facade and a sign reading "The Kentucky Center".

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Check availability on Southern Indiana Luxury Hotels

Tonight

Oct 18 - Oct 19

Tomorrow

Oct 19 - Oct 20

Next weekend

Oct 23 - Oct 25

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Our top choices for Southern Indiana luxury hotels

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

1. The Brown Hotel

Downtown Louisville

Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.

￥19,800

￥23,298 total

includes taxes & fees

Oct 28 - Oct 29

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

2. 21c Museum Hotel Louisville

Downtown Louisville

Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.

￥24,041

￥29,076 total

includes taxes & fees

Nov 8 - Nov 9

A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.

A long table set with white tablecloths, gold chargers, and clear glassware.

A covered porch with a brick wall, a wooden door, and a hanging light fixture.

A marble countertop with a tray of colorful glassware, a bottle, and two glasses. A framed painting hangs above, and two lamps are on either side.

3. The Pepin Mansion Historic B&B

New Albany

￥17,773

￥20,084 total

includes taxes & fees

Nov 12 - Nov 13

A bedroom with a large bed, a wooden floor, a white door, and a painting on the wall.

A dining area with a piano, a large woven pendant light, and a patterned rug.

A living room with a dining area, white cabinetry, a flat-screen TV, and a large patterned rug.

A cozy living room with a staircase, a sofa, a patterned rug, and a small table with a lamp.

4. Eclectic & Unique Historic Home

New Albany

￥27,654

￥76,604 total

includes taxes & fees

Oct 19 - Oct 20

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A covered outdoor seating area with wicker furniture and a wooden railing.

5. Louisville Bourbon Inn

Old Louisville

Luxurious bourbon country retreat offers elegant rooms with Egyptian cotton sheets and champagne service just minutes from downtown.

￥44,087

￥51,172 total

includes taxes & fees

Oct 19 - Oct 20

A wooden deck with a table, chairs, and a lantern.

A large, historic house with a green roof, multiple chimneys, and a prominent front porch.

A grand staircase with dark wood railings and a chandelier.

A cozy porch area with wicker furniture, a ceiling fan, string lights, and a welcome sign.

6. Inn at Woodhaven

St. Matthews

￥37,735

￥43,800 total

includes taxes & fees

Nov 1 - Nov 2

A modern kitchen with white cabinetry, a large island with bar stools, and a wood floor.

A bedroom with a bed, a ceiling fan, a TV, and a window with curtains.

A room with a foosball table, two ping pong tables, and a blue chair.

A modern kitchen with white cabinets, a wooden dining table, and a ceiling fan.

7. Creation Museum Hot Tub 4BR for 10

Burlington

￥42,805

￥87,867 total

includes taxes & fees

Oct 19 - Oct 20

View all properties

Top Southern Indiana Hotel Reviews

Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

8/10 Good

"Bed was clean and very comfortable. The toilet sat very low however, the bathroom was very clean. Breakfast bar was extremely good and well maintained and frequently stocked by the employees. Would recommend this facility."

Spark by Hilton Evansville East, IN

Spark by Hilton Evansville East, IN

8/10 Good

"nice place and affordable"

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