Southeastern Indiana Vacations

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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southeastern Indiana Vacation Packages

Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive, Clarksville, IN
Fully refundable
The price is ￥8,683 per night from Sep 25 to Sep 26
￥8,683
￥9,812 total
Sep 25 - Sep 26
includes taxes & fees
6.8/10 (2,281 reviews)
"Everything was good"

Reviewed on Aug 22, 2025

Radisson Hotel Louisville North
Sheraton Louisville Riverside by Marriott

Sheraton Louisville Riverside by Marriott

3.5 out of 5
700 West Riverside Drive, Jeffersonville, IN
Fully refundableReserve now, pay when you stay
The price is ￥13,665 per night from Sep 1 to Sep 2
￥13,665
￥15,442 total
Sep 1 - Sep 2
includes taxes & fees
8.2/10 Very Good! (1,003 reviews)
A little outdated, the staff makes up for it!
"Its outdated some but mot terrible. The staff went above and beyond!!"

Reviewed on Aug 17, 2025

Sheraton Louisville Riverside by Marriott
Comfort Inn & Suites Clarksville - Louisville North

Comfort Inn & Suites Clarksville - Louisville North

2.5 out of 5
1485 Broadway St, Clarksville, IN
Fully refundableReserve now, pay when you stay
The price is ￥14,238 per night from Sep 1 to Sep 2
￥14,238
￥16,089 total
Sep 1 - Sep 2
includes taxes & fees
8.8/10 Excellent! (971 reviews)
"The property was very nice. There is only like 10 parking spots on the property which made an inconvenience late at night with a small child."

Reviewed on Aug 18, 2025

Comfort Inn & Suites Clarksville - Louisville North
See all 1,020 properties in Southeastern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southeastern Indiana

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum
Helped celebrate the Belle of Louisville's 100th birthday with a cruise up the Ohio River.

Louisville Waterfront Park

4.5/5(301 reviews)

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its great live music.

Louisville Waterfront Park
Muhammad Ali Center featuring modern architecture and night scenes

Muhammad Ali Center

4.5/5(243 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

Muhammad Ali Center

Frequently asked questions

How much does a Southeastern Indiana vacation package cost?
Our Southeastern Indiana vacation packages, which start from just , are an ideal way to save loads of cash. Pick and choose your preferred flights, hotels and rental cars to create a custom-built escape.
How do I get a cheap travel package to Southeastern Indiana?
If you love landing a bargain, bundle your bookings into a Southeastern Indiana vacation package. Whether you need flights, hotels, activities or rental cars, you can browse and book everything in one place. You'll have loads of choice at your fingertips too. Expedia has over 550 partner airlines and 1,000,000 hotel options throughout the world to choose from. Fly with who you want, stay wherever you like and save your hard-earned money — now that's the ideal escape!
Where should I stay in Southeastern Indiana?
You'll adore Louisville. Well-known attractions, such as Churchill Downs and Muhammad Ali Center, will keep you entertained in this happening city.
What are the top hotels in Southeastern Indiana?
Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville know how to make their guests feel at home in Louisville. If you also plan to stay in Jeffersonville - Clarksville, have a look at Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis. Both are top picks with travelers.
How far in advance should I book my Southeastern Indiana vacation?
It can be difficult to know when is the perfect time to book your Southeastern Indiana vacation. But usually the earlier you book, the more affordable the prices. In some cases, you can book your flights and hotels up to 12 months prior to your departure date. If you're thinking of a last-minute getaway, no need to fret! There are fabulous deals posted on Expedia every single day.
What does an Expedia Southeastern Indiana travel package include?
Packages include rental cars, flights and hotels, but you can mix and match them to create your perfect Southeastern Indiana vacation. You can also add on fun things like experiences and activities once you've made your booking. You're in the driver's seat! When you bundle your bookings with Expedia, you'll get access to deals you won't find anywhere else.
What should I know before booking a Southeastern Indiana travel package?
Whether it's adventure or relaxation you're craving, a Southeastern Indiana vacation package lets you organize your escape your way. Plus, you'll get access to great discounts just for combining your hotel with your rental car and flights. The more you bundle, the bigger the savings!
Can I choose my airline with a Southeastern Indiana Expedia vacation package?
Expedia has access to more than 550 partner airlines globally, so you definitely can. Just select your preferred carrier and craft your ideal Southeastern Indiana escape.
If I'm not able to travel, can I cancel my Southeastern Indiana vacation package?
Whether it's your hotel, flight or rental car, you can cancel or alter it. Booked your Southeastern Indiana vacation package in the last 24 hours? You may be able to make changes at no cost. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For further information, look up our Customer Service Portal. We'll help you each step of the way.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.