Santa Maria Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

    Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
Default Image

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town.

Find hotels in Downtown Guayaquil

Santa Maria Hotel Deals

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N, Ciudad del Rio - Puerto Santa Ana, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
The price is ￥16,784 per night from Nov 9 to Nov 10
￥16,784
￥18,844 total
Nov 9 - Nov 10
9.2/10 Wonderful! (1,013 reviews)
All good

Reviewed on Oct 20, 2025

Wyndham Guayaquil Puerto Santa Ana
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto, Intl. Jose Joaquin de Olmedo, Guayaquil, Guayas
Fully refundable
The price is ￥13,605 per night from Nov 3 to Nov 4
￥13,605
￥15,347 total
Nov 3 - Nov 4
9.2/10 Wonderful! (1,017 reviews)
Nice and clean. Also, the staff is really great helpful for everything you ask.

Reviewed on Oct 25, 2025

Holiday Inn Guayaquil Airport by IHG
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
The price is ￥13,605 per night from Nov 3 to Nov 4
￥13,605
￥15,347 total
Nov 3 - Nov 4
9.4/10 Exceptional! (1,016 reviews)
Very nice room with fresh fruit available in the 8th floor lobby

Reviewed on Oct 20, 2025

Oro Verde Guayaquil
See all 402 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Maria vacation package cost?
Get set to book, because a getaway to Santa Maria starts from a tempting . When you combine your hotels, flights and car rentals into a travel package, you'll enjoy the lowest prices.
How do I get a cheap travel package to Santa Maria?
Bundle your hotels and flights with Expedia to save big on your next trip. With more than 550 air carriers and 1,000,000 hotels worldwide, your Santa Maria vacation package can be customized exactly to suit your travel style. With all that extra cash, why not add a few fun activities and tours? It's an easy way to unlock even more savings. Your dream vacation in Santa Maria is closer than you thought!
Where should I stay in Santa Maria?
Make sightseeing easy by staying someplace right around the corner from Santa Maria's biggest attractions. Malecon 2000 and Banco Pichincha Monumental Stadium are two visitor favorites.
How far in advance should I book my Santa Maria vacation?
Your safest bet is to book early. Airlines usually release flight tickets nearly 12 months prior to departure, and this is a great opportunity to score some rock-bottom prices. Just been told you should take your vacation time next month? No sweat. Expedia are never short on fantastic bargains to help you have the getaway of your dreams, at an affordable price.
What does an Expedia Santa Maria travel package include?
Select from any combination of flights, hotels and rental cars. Once you've made your booking, you can add activities and experiences. Want to pick your airfare class? That's easy to do too. The choice is all yours when it comes to arranging your dream Santa Maria escape.
What should I know before booking a Santa Maria travel package?
Get set to save with an Expedia travel package. Combine your flights, rental cars and hotels and enjoy exciting discounts. Hotels aren't your only choice, however. Book with us and choose from beach villas, creek-side mountain cabins and just about everything in between!
Can I choose my airline with a Santa Maria Expedia vacation package?
Expedia offers access to more than 550 airline partners globally, so you certainly can. Just pick your preferred air carrier and put together your ideal Santa Maria escape.
If I'm not able to travel, can I cancel my Santa Maria vacation package?
Yes, you can cancel your Santa Maria booking if your travel plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.

Things to do

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

￥9,792
per adult
100% of travellers recommend
Wine Tasting Experience with Tasting Menu
Making hot Chocolate!

Cocoa farm and Chocolate making!

￥23,531
per adult
Cocoa farm and Chocolate making!
Half Day Walking Tour of Guayaquil Pearl of the Pacific

Half Day Walking Tour of Guayaquil Pearl of the Pacific

￥15,181
per adult
Half Day Walking Tour of Guayaquil Pearl of the Pacific
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.