Find hotels in Santa Maria, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Feb 21 - Feb 22
Tomorrow
Feb 22 - Feb 23
Next weekend
Feb 27 - Mar 1
In two weeks
Mar 6 - Mar 8

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Maria hotels

Property entrance

DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (600 reviews)
"Great location and clean hotel"
United States
Elvin
The price is ￥5,303
￥5,458 total
Mar 1 - Mar 2
DC Suites Aeropuerto
Terrace/patio

Villa Celeste - VC

Villa Celeste - VC
2.5 star property
9.3 km from Santa Maria
7.4 out of 10, Good, (13 reviews)
"It is a good place, they respect your privacity and has a good communication with tourist places "
Mexico
Moises Reque
The price is ￥2,456
￥2,456 total
Mar 1 - Mar 2
Villa Celeste - VC
Terrace/patio

Casa Serena

Casa Serena
2.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (54 reviews)
"the property was ok for the price"
United States
ASONG
Casa Serena
Terrace/patio

Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport
4.0 star property
Garzota, 4.9 km from Santa Maria
8.8 out of 10, Excellent, (237 reviews)
"Great stay and great staff!"
United States
Jemima
Hotel Puerto Pacifico Guayaquil Airport
Outdoor pool

Tropical Inn

Tropical Inn
2.0 star property
9.2 km from Santa Maria
7.8 out of 10, Good, (17 reviews)
"for the price was good"
United States
Rosa
Tropical Inn
Terrace/patio

Harmonie

Harmonie
2.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (93 reviews)
"Friendly staff, great service! "
United States
Yerifer
The price is ￥4,652
￥4,652 total
Feb 22 - Feb 23
Harmonie
Economy Triple Room | Free WiFi, bed sheets

Hotel Dorado

Hotel Dorado
2.0 star property
8.1 km from Santa Maria
8.8 out of 10, Excellent, (13 reviews)
"Great location! Great value "
United States
John
The price is ￥3,139
￥3,139 total
Feb 26 - Feb 27
Hotel Dorado
Exterior

Hotel La Ria Durán

Hotel La Ria Durán
3.0 star property
9.8 km from Santa Maria
7.4 out of 10, Good, (20 reviews)
"Muy buena experiencia"
Ecuador
HERNAN
The price is ￥7,442
￥7,442 total
Mar 4 - Mar 5
Hotel La Ria Durán
Double Room, 1 Queen Bed, Private Bathroom, Ground Floor | Outdoor pool | Outdoor pool, sun loungers

MundialCity Hotel Guayaquil

MundialCity Hotel Guayaquil
3.0 star property
Simón Bolívar, 5.1 km from Santa Maria
8.4 out of 10, Very Good, (167 reviews)
"Room was great and very clean. The staff is amazingly friendly and nice. This will be my go to hotel from now on ."
United States
Gary
MundialCity Hotel Guayaquil
Executive Suite, Kitchenette, City View | Private kitchen | Microwave, electric kettle, griddle, cookware/dishes/utensils

Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil
4.5 star property
Garzota, 5.1 km from Santa Maria
9.2 out of 10, Wonderful, (11 reviews)
"You can walk to the airport."
United States
Digna
The price is ￥3,845
￥4,854 total
Mar 8 - Mar 9
Suitesecu Rentals Guayaquil
Down comforters, desk, free WiFi, bed sheets

Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 7.7 km from Santa Maria
8.4 out of 10, Very Good, (107 reviews)
"The air conditioning was great and the location was very good."
United States
Rommel
Hotel Las Peñas
Lobby sitting area

Casa Veranda

Casa Veranda
2.5 star property
8.9 km from Santa Maria
Casa Veranda
Cafe

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
5.5 km from Santa Maria
9.4 out of 10, Exceptional, (1,013 reviews)
"Clean and close to airport. "
United States
Silvia
The price is ￥13,532
￥15,273 total
Mar 20 - Mar 21
Holiday Inn Guayaquil Airport by IHG
Classic Double Room | Free WiFi

Pachamac House

Pachamac House
2.0 star property
6 km from Santa Maria
The price is ￥3,008
￥3,008 total
Mar 1 - Mar 2
Pachamac House
Suite, Jetted Tub | In-room safe, free WiFi, bed sheets

Hotel Varadero Internacional

Hotel Varadero Internacional
3.0 star property
Downtown Guayaquil, 6.6 km from Santa Maria
8.0 out of 10, Very Good, (67 reviews)
"Overall a good place to stay and close to most destinations."
United States
Daniel
Hotel Varadero Internacional
Rooftop bar, alfresco dining, open daily

Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 4.8 km from Santa Maria
9.2 out of 10, Wonderful, (1,001 reviews)
"Great room convenient location "
United States
Jorge
The price is ￥12,404
￥13,877 total
Feb 22 - Feb 23
Wyndham Garden Guayaquil
Outdoor pool, sun loungers

Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast
3.5 star property
3 km from Santa Maria
9.2 out of 10, Wonderful, (47 reviews)
"Excelente Todo "
Costa Rica
Cesar
The price is ￥8,889
￥9,951 total
Mar 1 - Mar 2
Iguanazu Bed & Breakfast
Comfort Double Room | In-room safe, desk, free WiFi, bed sheets

Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 7.3 km from Santa Maria
8.4 out of 10, Very Good, (37 reviews)
"Great value hot water clean friendly staff on site restaurant "
United States
Monty
Hotel GH Alexander
Living area

NP Hotel & Suites

NP Hotel & Suites
3.0 star property
5.6 km from Santa Maria
The price is ￥10,734
￥10,889 total
Feb 26 - Feb 27
NP Hotel & Suites
Lobby lounge

Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 7.8 km from Santa Maria
8.8 out of 10, Excellent, (136 reviews)
"Breakfast was good. I enjoyed my scrambled eggs and toast "
United States
Caitlin
The price is ￥9,210
￥10,286 total
Mar 6 - Mar 7
Mansión del Río
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most.
Fachada colorida de estilo colonial, barrio de Santa Ana, Guayaquil, Ecuador

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

They are here because people started feeding them
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town.

Vista panorámica de las favelas de cerro santa ana, guayaquil, ecuador

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Botanical Garden while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

Cityscape from Malecón 2000, the boardwalk overlooking the Guayas River in Guayaquil, Ecuador's largest city and economic capital.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Bolívar

While Bolívar isn't home to many top sights, Malecon Mall and Central Market are some notable places to visit nearby.

Top Santa Maria Hotel Reviews

Harmonie

Harmonie

10/10 Excellent
"Room was spotless, the staff was wonderful and helpful I can’t wait to visit again "
Marco 2-night trip
Posted 11 hours ago
Harmonie

Frequently asked questions

What is Santa Maria like?
Travelers are sure to enjoy a stay in Guayaquil's Santa Maria neighborhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then filter by "fully refundable" to get the best options available in Santa Maria.
Where can I learn more about changing or cancelling my trip to Santa Maria?
For more information about changing or cancelling your trip to Santa Maria, go to https://www.expedia.com/service/.
What can I see and do in this Guayaquil neighborhood?
Salón de Eventos Rubi, City Mall, and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Santa Ana Port are also worth a visit when you're out sightseeing in Guayaquil.