Santa María Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Santa María Hotel Deals

Hotel De La Peña Inn

Hotel De La Peña Inn

3 out of 5
Carretera Transístmica No. 7 Tehuantepec OAX
Fully refundableReserve now, pay when you stay
8/10 Very Good! (37 reviews)
Very clean. Spotless and pleasant service.

Reviewed on Oct 30, 2025

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Hotel De La Peña Inn
One Salina Cruz

One Salina Cruz

3 out of 5
Carretera Transistmica No. 10 Km. 5 Salina Cruz OAX
Fully refundableReserve now, pay when you stay
The price is ￥8,222 per night from Jan 26 to Jan 27
￥8,222
￥9,785 total
Jan 26 - Jan 27
includes taxes & fees
9/10 Wonderful! (432 reviews)
Room was comfortable. Good location. The breakfast was delicious.

Reviewed on Jan 10, 2026

One Salina Cruz
Hotel Santa Cruz Juchitan

Hotel Santa Cruz Juchitan

3 out of 5
Carretera Transistmica KM 818 Juchitan de Zaragoza OAX
Fully refundableReserve now, pay when you stay
7.6/10 Good! (116 reviews)
JAVIER, Guatemala
Conveniente for One night stay.

Reviewed on Nov 16, 2024

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Hotel Santa Cruz Juchitan
See all 23 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa María vacation package cost?
Starting from as low as , a vacation package is your ticket to affordable travel. Customize your Santa Marían adventure by picking from our huge range of hotels, flights and rental cars.
How do I get a cheap travel package to Santa María?
If you love amazing deals, bundle your bookings into a Santa María vacation package. Whether you need flights, hotels, activities or rental cars, you can browse and book them all in one place. You'll have a wealth of choice at your fingertips too. Expedia has over 550 airlines and 1,000,000 hotels around the world to take your pick of. Fly with who you prefer, check in where you like and save some cash — now that's the perfect escape!
Where should I stay in Santa María?
A getaway to Santa Marían isn't complete without visiting Guiengola. Why not choose a hotel near this much-loved tourist attraction?
What are the top hotels in Santa María?
If it's comfort and convenience you're searching for, you can't go past Hotel De La Peñan Inn. Spend your nights relaxing here and your days wandering around Santa María's popular attractions.
How far in advance should I book my Santa María vacation?
Travelers can normally look up international airfares on Expedia within 12 months of departure. Booking late? With a bit of luck, it's still possible to score an affordable ticket just weeks before your journey.
What does an Expedia Santa María travel package include?
With Expedia, you can choose a combination of hotels, flights and car rentals to create your perfect Santa María package. Once you've made your booking, you can add on fun stuff like activities and tours. Remember — the more you bundle, the more dollars you'll save!
What should I know before booking a Santa María travel package?
You can save a tidy sum by combining your hotels, airfares and rental cars. Once you've created your package, you can add on things like activities or tours. Your next awesome adventure is only a couple of clicks away.
Can I choose my airline with a Santa Marían Expedia vacation package?
Yes — and it's easy too. Expedia has access to more than 550 partner airlines worldwide. Our vacation packages give you the freedom to pick from available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my Santa María vacation package?
We get it — unexpected stuff happens. If you've booked a Santa María vacation package and have to cancel or amend it, we can help. We suggest checking out our Customer Service Portal first for information. But generally speaking, if you've booked your package within 24 hours, you may be able to cancel or change your itinerary free of charge. If it's been longer than 24 hours, your airline, hotel or car rental company may impose a charge.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.