Santa Cruz Vacations

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Find the Best Santa Cruz Vacation Packages

Santa Cruz Hotel Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is ￥19,359 per night from Aug 23 to Aug 24
￥19,359
￥19,359 total
Aug 23 - Aug 24
9/10 Wonderful! (392 reviews)
"Wildlife on property. Great breakfast. Amazing spa. Great rooms. Professional atmosphere. My favorite hotel in Santa Cruz."

Reviewed on Jul 21, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is ￥8,719 per night from Aug 16 to Aug 17
￥8,719
￥8,719 total
Aug 16 - Aug 17
9.4/10 Exceptional! (127 reviews)
"Hotel muy lindo bien ubicado limpio el desayuno bueno y el personal A1 …. Totalmente recomendado"

Reviewed on Jul 22, 2026

Ibis Santa Cruz DE LA Sierra
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este Santa Cruz
The price is ￥13,125 per night from Jul 26 to Jul 27
￥13,125
￥13,125 total
Jul 26 - Jul 27
9.2/10 Wonderful! (166 reviews)
"Good Hotel, nice to walk and Good Restaurants. In my room they have a problem with the design of the bathroom that they have to take care."

Reviewed on Jun 26, 2026

TRYP by Wyndham Santa Cruz
See all 298 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
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What to do in Santa Cruz

Santa Cruz: Wildlife Sanctuary and Preservation Park Tour

Santa Cruz: Wildlife Sanctuary and Preservation Park Tour

￥13,816
per adult
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
The Che Guevara route is the most peculiar tourist destination in Bolivia.

4D/3N Expedition: Che Guevara Route - Disconnect from the World

￥129,869
per adult
4D/3N Expedition: Che Guevara Route - Disconnect from the World
Fuerte de Samaipata, Bolivia

Samaipata Fort Tour: Ancient Ruins in 1 Full Day

￥51,200
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
See all activities in Santa Cruz

Frequently asked questions

How much does a Santa Cruz vacation package cost?
You'll find cheap prices on Expedia for your Santa Cruz break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
February, April and May are the best times to look for cheap Santa Cruz vacation packages. Opting to travel in quieter months means you can typically find lower prices on hotels and flights.
How many days is enough for Santa Cruz?
Typically, a handful of days is enough to tick off the main sights during your Santa Cruz vacation. However, if you prefer to have some time to kick back or take day tours, think about extending your itinerary.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Ventura Mall among the many things to keep you busy. Whether you're traveling with the family or getting away with friends, a Santa Cruz vacation promises a good time for everyone.
How to find the best Santa Cruz package deals?
Use Expedia's filters to help you find some tempting Santa Cruz package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Santa Cruz package deals in the off-peak season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz escape by booking a personalized vacation package. Click on the "Package" heading, then enter your travel dates and destination to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Cruz?
If you're considering an impromptu Santa Cruz adventure, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find sensational deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Cruz?

  1. Choose your dates: What you want to do in Santa Cruz and your favorite season will help you decide when to get away.
  2. Work out your budget: Make sure you have enough money to pay for everything from transportation and dining out to experiences and flights. Your hotel will probably be the biggest expense during your trip to Santa Cruz.
  3. Work out your trip length: Consider how much time you want to spend discovering Santa Cruz. Plan your days so you can get to all the experiences and attractions you're interested in without rushing.
  4. Combine your hotel and flights: Epic destination, check. Length of stay, check. All that's left is to choose a Santa Cruz vacation package that brings all your bookings together.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.