Santa Cruz Vacations from ￥374,752
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Swissôtel Santa Cruz De La Sierra
￥391,486
per person
Oct 29 - Nov 3
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Santa Cruz (VVI)
9.2/10 Wonderful! (89 reviews)
Hospedagem muito boa, hotel limpo e bem cuidado, café da manhã bom, funcionários atenciosos e prestativos. Recomendo.
Reviewed on Jul 13, 2026
Find the Best Santa Cruz Vacation Packages
Santa Cruz Hotel Deals
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
￥6,813
￥6,813 total
Sep 11 - Sep 12
9.4/10 Exceptional! (137 reviews)
"La ubicación es muy buena y puedes caminar por la zona"
Reviewed on Aug 31, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
￥22,447
￥22,447 total
Sep 13 - Sep 14
Marriott Santa Cruz de la Sierra Hotel
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
￥16,529
￥16,529 total
Oct 2 - Oct 3
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Santa Cruz attractions
Plaza 24 de Septiembre
8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
San Lorenzo Cathedral
9.0/10 (84 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
Ventura Mall
9.0/10 (183 reviews)
Ventura Mall, Santa Cruz's premier shopping destination, features international brands and local boutiques. Enjoy the cinema complex, food court, and entertainment options in this contemporary Bolivian retail hub.
Guembe Biocenter
8.8/10 (60 reviews)
This vibrant ecological sanctuary showcases hundreds of butterfly species in a lush, tropical environment. Explore walking trails, enjoy boat rides, and learn about biodiversity in this serene natural retreat.
Santa Cruz Zoo
8.4/10 (53 reviews)
The Santa Cruz Municipal Zoo showcases Bolivia's native wildlife in naturalistic habitats, featuring jaguars, tapirs, and free-ranging sloths. Morning visits offer the best chance to see active animals.
Cine Center
8.0/10 (53 reviews)
This premier entertainment complex offers state-of-the-art cinema experiences with immersive 4D E-Motion formats. Enjoy the latest films, then explore the shopping center and diverse dining options in the food court.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
This multi-purpose stadium hosts Bolivia's most passionate football rivalries and tournaments. Experience the electric atmosphere of a local derby while enjoying modernized facilities and vibrant Santa Cruz culture.
Las Brisas Shopping Center
8.4/10 (40 reviews)
This modern complex offers 80+ stores, a nine-screen cinema, and a unique outdoor restaurant promenade. Explore the gastronomic boulevard for dining experiences beyond the standard food court options.
What to do in Santa Cruz
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
￥13,608
per adult
4D/3N Expedition: Che Guevara Route - Disconnect from the World
￥127,912
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
￥50,428
per adult
Frequently asked questions
How much does a Santa Cruz vacation package cost?
You'll find cheap prices from ￥374,752 on Expedia for your Santa Cruz break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
February, April and May are the best times to look for cheap Santa Cruz vacation packages. Opting to travel in quieter months means you can typically find lower prices on hotels and flights.
How many days is enough for Santa Cruz?
Typically, a handful of days is enough to tick off the main sights during your Santa Cruz vacation. However, if you prefer to have some time to kick back or take day tours, think about extending your itinerary.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Ventura Mall among the many things to keep you busy. Whether you're traveling with the family or getting away with friends, a Santa Cruz vacation promises a good time for everyone.
How to find the best Santa Cruz package deals?
Use Expedia's filters to help you find some tempting Santa Cruz package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Santa Cruz package deals in the off-peak season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz escape by booking a personalized vacation package. Click on the "Package" heading, then enter your travel dates and destination to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Cruz?
If you're considering an impromptu Santa Cruz adventure, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find sensational deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Cruz?
- Choose your dates: What you want to do in Santa Cruz and your favorite season will help you decide when to get away.
- Work out your budget: Make sure you have enough money to pay for everything from transportation and dining out to experiences and flights. Your hotel will probably be the biggest expense during your trip to Santa Cruz.
- Work out your trip length: Consider how much time you want to spend discovering Santa Cruz. Plan your days so you can get to all the experiences and attractions you're interested in without rushing.
- Combine your hotel and flights: Epic destination, check. Length of stay, check. All that's left is to choose a Santa Cruz vacation package that brings all your bookings together.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
