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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Aug 7 - Aug 9
In two months
Sep 18 - Sep 20
In three months
Oct 16 - Oct 18
In four months
Nov 13 - Nov 15

Our top choices for Santa Cruz vacation rentals

Living area

Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.2 out of 10, Wonderful, (42 reviews)
"Increíble view.. comfortable clean!! "
United States
Hector
The price is ￥12,319
￥14,753 total
Jul 29 - Jul 30
Skyline Ecoliving
Restaurant

Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (64 reviews)
"Awesome breakfast, great location. Great host"
United States
James
The price is ￥6,318
￥6,318 total
Aug 25 - Aug 26
Edificio Helena
Coffee shop

B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (20 reviews)
"I love the people & I love the area. One of the best place to stay in Medellin. "
United States
Lusene
The price is ￥9,381
￥9,381 total
Jul 27 - Jul 28
B 48 Living by B Rent
Comfort Double Room | Premium bedding, down comforters, minibar, WiFi (free)

Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (3 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is ￥4,018
￥4,018 total
Jul 27 - Jul 28
Hotel Moore 45
Reception

Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.2 out of 10, Wonderful, (73 reviews)
"Staff was very polite, location was perfect… very close to amazing tourism spots! "
United States
Patricia
The price is ￥8,166
￥11,770 total
Aug 10 - Aug 11
Metropolitan Living by HOUSY
Restaurant

Hotel Distrito 70 Living

Hotel Distrito 70 Living
3.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (4 reviews)
"great location. cooked to order eggs n fruit for breakfast w juice n coffee...clean room with a/c...nothing to complain about,,,"
United States
howard
The price is ￥7,266
￥7,266 total
Aug 26 - Aug 27
Hotel Distrito 70 Living
WiFi (free)

hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
8.8 out of 10, Excellent, (3 reviews)
"Hotel in a good location, comfortable and has a great staff."
United States
Valencia
The price is ￥4,233
￥4,233 total
Jul 31 - Aug 1
hotel civitas medellin
Comfort Apartment | Living area | Flat-screen TV

Loft 43

Loft 43
3.0 star property
Laureles
8.6 out of 10, Excellent, (32 reviews)
"Fabulous room with floor to ceiling windows, comfortable bed, hot water in the shower and a strong wifi connection. Close to Estadio metro station and La Setenta for food and nightlife. Staff were friendly and check-in was fast. Light sleepers might find the neighborhood a bit loud. There are many local restaurants along Calle 43 (just head away from La 70) for lunch and dinner."
United States
Daniel
The price is ￥8,965
￥8,965 total
Aug 26 - Aug 27
Loft 43
Outdoor spa tub

Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (107 reviews)
"Beautiful hotel great location great breakfast"
United States
gary
The price is ￥6,927
￥6,927 total
Aug 17 - Aug 18
Quadrato Studios
Full-size fridge, microwave, oven, stovetop

Luxury Suites Prana By Cadissa

Luxury Suites Prana By Cadissa
5.0 star property
Laureles - Estadio
9.4 out of 10, Exceptional, (50 reviews)
"It was very easy to check in and out. The apartment had everything we needed to be comfortable. The location was great. We were able to walk around and felt very safe. I highly recommend it if you are looking for an affordable place with good customer service and cleanliness."
United States
Mahely
The price is ￥12,978
￥19,845 total
Aug 17 - Aug 18
Luxury Suites Prana By Cadissa
Lobby sitting area

HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (101 reviews)
"The staff was very friendly—Juliana, in particular, was very kind. There is a security company with a 24/7 guard in the building across the street."
United States
Moraima
The price is ￥8,067
￥13,310 total
Aug 10 - Aug 11
HOUSY Laureles
Free daily full breakfast

Laureles Guest House - LGH Hotel

Laureles Guest House - LGH Hotel
3.5 star property
Laureles
9.2 out of 10, Wonderful, (100 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is ￥7,416
￥7,416 total
Jul 27 - Jul 28
Laureles Guest House - LGH Hotel
Staircase

zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (55 reviews)
"Wonderful place. Brilliant staff."
United States
Moriah
The price is ￥5,001
￥5,001 total
Aug 19 - Aug 20
zenia
Superior Studio, 1 Queen Bed, Kitchen | Premium bedding, in-room safe, desk, laptop workspace

The Somos Flats Laureles

The Somos Flats Laureles
4.0 star property
Laureles
9.0 out of 10, Wonderful, (63 reviews)
"Great property and very accommodating host."
United States
Joseph
The price is ￥9,252
￥9,252 total
Aug 11 - Aug 12
The Somos Flats Laureles
Deluxe Apartment, 1 Queen Bed with Sofa bed, Non Smoking, Kitchen | 1 bedroom, premium bedding, down comforters, in-room safe

Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.0 out of 10, Wonderful, (288 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is ￥12,992
￥12,992 total
Aug 10 - Aug 11
Portal del Rodeo ApartaHotel - Arkadia Mall
Loft, 1 Double Bed | Egyptian cotton sheets, premium bedding, down comforters

Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (132 reviews)
"Amazing experience. The staff was extremely helpful and some spoke good english."
United States
Thomas
The price is ￥16,096
￥20,674 total
Jul 27 - Jul 28
Factory Lofts
Outdoor pool

Casa Museo by HOUSY

Casa Museo by HOUSY
3.5 star property
Laureles
8.4 out of 10, Very Good, (5 reviews)
"I highly recommend staying here. It’s centrally located, comfortable, clean, and the service is excellent."
United States
Carlos
The price is ￥7,927
￥12,514 total
Aug 26 - Aug 27
Casa Museo by HOUSY
Deluxe Studio | Living area | 55-inch Smart TV with cable channels, streaming services

Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.2 out of 10, Wonderful, (138 reviews)
"Excellent place to stay."
United States
Rexford
The price is ￥10,170
￥10,170 total
Jul 27 - Jul 28
Kyux by Jalo
Front of property

Nomadic Boutique Living and Experience Center

Nomadic Boutique Living and Experience Center
4.0 star property
El Poblado
9.8 out of 10, Exceptional, (21 reviews)
"Good property and the area looks safe."
Canada
Josue
The price is ￥9,800
￥11,072 total
Aug 23 - Aug 24
Nomadic Boutique Living and Experience Center
Junior Studio | Down comforters, blackout drapes, WiFi (free), bed sheets

Amaranto Suites

Amaranto Suites
3.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (6 reviews)
"Perfect"
United States
Alexander
The price is ￥6,508
￥6,508 total
Aug 11 - Aug 12
Amaranto Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Hunters Hotel Medellín

Hunters Hotel Medellín

8/10 Good
"This hotel is in a perfect location. Staff and cleanliness are great. The only reason I’m giving it 4 stars versus 5 is the comfort of the bed is TERRIBLE and the lighting is mediocre in the room when trying to get ready. Other than that this is the second time staying here this year and would again for the price and location."
Angela 7-night trip
Posted 1 hour ago
Hunters Hotel Medellín

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

Luxury Home In Las Lomas: You might want to consider this vacation home rental near Santa Cruz, which is equipped with an outdoor pool, air-conditioning, and free WiFi to help you feel comfortable during your stay. It has 6 bedrooms as well as a kitchen with a full-sized fridge, a microwave, and a coffee maker, so you can cook with friends or family.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.