A colonial-style building with a bell tower, palm trees, and a paved walkway.

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Oct 1 - Oct 2
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Oct 2 - Oct 3
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Oct 2 - Oct 4
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Oct 9 - Oct 11

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Our top choices for Santa Cruz hotels

1. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
United States
Scott
¥11,582
¥11,582 total
Oct 3 - Oct 4
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

2. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
Equipetrol
United States
Pluetina
¥17,153
¥17,153 total
Oct 10 - Oct 11
TRYP by Wyndham Santa Cruz

3. Sun Hotel

Sun Hotel
Santa Cruz
United States
Ivan
¥16,656
¥16,656 total
Oct 9 - Oct 10
Sun Hotel

4. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Equipetrol
United States
Daniel
¥25,281
¥25,281 total
Oct 10 - Oct 11
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

5. Camino Real Hotel

Camino Real Hotel
Santa Cruz
United States
Wendy
¥25,318
¥25,318 total
Nov 1 - Nov 2
Camino Real Hotel

6. Hotel Las Américas

Hotel Las Américas
Centro Histórico
Canada
Stanley
¥4,107
¥4,107 total
Oct 3 - Oct 4
Hotel Las Américas

7. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
Santa Cruz
United States
Luisa
¥6,590
¥6,590 total
Oct 4 - Oct 5
Premium Suites Deluxe Aparthotel Equipetrol

8. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
Equipetrol
United States
Hui Hua
¥6,121
¥6,121 total
Oct 16 - Oct 17
Ibis Santa Cruz DE LA Sierra

9. HOTEL OSHO

HOTEL OSHO
Santa Cruz
Canada
David
¥7,406
¥7,406 total
Oct 2 - Oct 3
HOTEL OSHO

10. Hotel Cortez

Hotel Cortez
Equipetrol
United States
Leonora
¥18,643
¥18,643 total
Nov 1 - Nov 2
Hotel Cortez

11. Lido Hotel

Lido Hotel
Centro Histórico
United States
Gabrielle
¥3,681
¥3,681 total
Oct 27 - Oct 28
Lido Hotel

12. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
United States
Deivis
¥16,653
¥16,653 total
Nov 1 - Nov 2
Marriott Santa Cruz de la Sierra Hotel

13. Chairú Eco Hotel

Chairú Eco Hotel
Santa Cruz
United States
Luis
¥7,438
¥7,438 total
Nov 1 - Nov 2
Chairú Eco Hotel

14. Hotel Arenal

Hotel Arenal
Centro Histórico
United States
Max
¥9,350
¥9,350 total
Oct 5 - Oct 6
Hotel Arenal

15. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
Santa Cruz
United States
Ruben
¥4,251
¥4,251 total
Oct 2 - Oct 3
Apart Hotel Premium Suites Santa Cruz

16. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
Centro Histórico
¥8,668
¥8,668 total
Oct 10 - Oct 11
Gran Hotel Santa Cruz

17. Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
Equipetrol
United States
Elizabeth
¥16,779
¥16,779 total
Oct 15 - Oct 16
Alfonsina Hotel Boutique by Inboccaluppo

18. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
Santa Cruz
United States
ERNESTO
¥20,277
¥20,277 total
Oct 11 - Oct 12
Novotel Santa Cruz De La Sierra

19. Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
Centro Histórico
United States
Veronica
¥9,054
¥9,054 total
Oct 9 - Oct 10
Cosmopolitano Hotel Boutique

20. Hotel Pascana centro

Hotel Pascana centro
Centro Histórico
¥6,968
¥6,968 total
Oct 21 - Oct 22
Hotel Pascana centro
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Vacation Rentals in Santa Cruz

Aparthotel

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
Santa Cruz
"great place to stay!"
Premium Suites Deluxe Aparthotel Equipetrol
Apartment

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
Santa Cruz
"Great location."
Apart Hotel Premium Suites Santa Cruz
Aparthotel

Terranova Suites

Terranova Suites
Santa Cruz
"Easy to access"
Terranova Suites
Aparthotel

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
Santa Cruz
"Perfect hotel"
Equipetrol Suites Apart Hotel
Apartment

AMERICA APARTMENTS

AMERICA APARTMENTS
Santa Cruz
"Clean room, great staff "
AMERICA APARTMENTS
Aparthotel

Apart Hotel Toborochi

Apart Hotel Toborochi
Equipetrol
"Very comfortable and quiet place and very good location. "
Apart Hotel Toborochi
See all vacation rentals
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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.Learn more about Santa Cruz
Learn more about Santa Cruz

Equipetrol

Though Equipetrol might not have many top sights, you can venture to the surrounding area to see attractions like Santa Cruz Zoo and Municipal Library.

Centro Histórico

If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.

Hamacas

While Hamacas isn't home to many top sights, Las Brisas Shopping Center and Santa Cruz Zoo are some notable places to visit nearby.

Zona Sur (South Zone)

Zona Sur (South Zone) might not have many top sights, but Ramon Tahuichi Aguilera Stadium and Plaza 24 de Septiembre are two attractions nearby that you can check out.

Urubó

While Urubó might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Guembe Biocenter and Ventura Mall.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
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An interior of a church with high arched ceilings, wooden pews, and a central altar.

San Lorenzo Cathedral

9.0/10 (84 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
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Ventura Mall

9.0/10 (183 reviews)
Ventura Mall, Santa Cruz's premier shopping destination, features international brands and local boutiques. Enjoy the cinema complex, food court, and entertainment options in this contemporary Bolivian retail hub.
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Guembe Biocenter

8.8/10 (60 reviews)
This vibrant ecological sanctuary showcases hundreds of butterfly species in a lush, tropical environment. Explore walking trails, enjoy boat rides, and learn about biodiversity in this serene natural retreat.
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Ramon Tahuichi Aguilera Stadium

8.4/10 (18 reviews)
This multi-purpose stadium hosts Bolivia's most passionate football rivalries and tournaments. Experience the electric atmosphere of a local derby while enjoying modernized facilities and vibrant Santa Cruz culture.
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Las Brisas Shopping Center

8.4/10 (40 reviews)
This modern complex offers 80+ stores, a nine-screen cinema, and a unique outdoor restaurant promenade. Explore the gastronomic boulevard for dining experiences beyond the standard food court options.
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Santa Cruz Zoo

8.4/10 (53 reviews)
The Santa Cruz Municipal Zoo showcases Bolivia's native wildlife in naturalistic habitats, featuring jaguars, tapirs, and free-ranging sloths. Morning visits offer the best chance to see active animals.
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Blacutt Square

8.2/10 (19 reviews)
Plaza Blacutt offers a verdant escape in Santa Cruz with mature trees shading tiled pathways. Enjoy local flavors from vendors along the northern edge while children play in the well-equipped playground areas.
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Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A colonial-style building with a bell tower, palm trees, and a paved walkway.

Top Santa Cruz Hotel Reviews

Chairú Eco Hotel

Chairú Eco Hotel

8/10 Good
"The breakfast was not that good, but everything was good"
Olga Lidia 2-night trip
Posted 4 days ago
Chairú Eco Hotel
Hotel Cortez

Hotel Cortez

8/10 Good
"Clean room but it was not fully ready for me when I arrived."
Shawna 1-night trip
Posted 7 days ago
Hotel Cortez
Sun Hotel

Sun Hotel

10/10 Excellent
"Very nice place to stay. Close to the airport with shuttle to the hotel."
Richard 1-night trip
Posted 3 weeks ago
Sun Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

10/10 Excellent
"The room was very clean and the breakfast was fantastic. Overall it was a great experience."
Scott 7-night trip
Posted 1 month ago
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

10/10 Excellent
"All around good price and location"
Alejandro 1-night trip
Posted 1 month ago
Novotel Santa Cruz De La Sierra
HOTEL OSHO

HOTEL OSHO

10/10 Excellent
"Good"
Nando 8-night trip
Posted 2 months ago
HOTEL OSHO
Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure

10/10 Excellent
"Todo muy bien"
lady 2-night trip
Posted 2 months ago
Delfines Collection Hotel By Mercure
Hotel LP Equipetrol

Hotel LP Equipetrol

8/10 Good
"El cuarto agradable, pero faltó servicio de ayuda para subir y bajar maletas, también servicio adecuado de taxi para moverse en Santa Cruz"
José Bernardo 1-night trip
Posted 3 months ago
Hotel LP Equipetrol
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

10/10 Excellent
"Great location."
Ruben 2-night trip
Posted 4 months ago
Apart Hotel Premium Suites Santa Cruz

More cheap stays in Santa Cruz

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

Equipetrol Santa Cruz Departamento de Santa Cruz
¥8,092
¥8,092 total
Oct 3 - Oct 4
Equipetrol Suites Apart Hotel
Ibiza Hostel

Ibiza Hostel

445 Santa Cruz Departamento de Santa Cruz
Get ratesIbiza Hostel
Amaca Hostal

Amaca Hostal

249 Independencia Santa Cruz Departamento de Santa Cruz
Get ratesAmaca Hostal
Casa Por Temporadas

Casa Por Temporadas

Barrio Las Pampitas, calle 3 Nro. 99 Santa Cruz Santa Cruz Department
Get rates
10/10 Exceptional! (1 review)
Casa Por Temporadas
HOTEL CASA BLANCA

HOTEL CASA BLANCA

Avenida Marcelo Terceros Zona Equipetrol Santa Cruz Santa Cruz de la Sierra
Get ratesHOTEL CASA BLANCA
Hotel Viru Viru II

Hotel Viru Viru II

Av. Alameda 72 - Zona Valle Sanchez Santa Cruz Santa Cruz de la Sierra
Get rates
4.8/10 (3 reviews)
Hotel Viru Viru II

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is one of the top choices for your stay based on our traveler data. This hotel offers a restaurant and free parking. Other good choices for your visit include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Marriott Santa Cruz de la Sierra Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other homes for rent in Santa Cruz include Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Residencial Ikandire II and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best accommodation for a family trip to Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.
What is the top LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Hotel Pascana centro and Swissôtel Santa Cruz De La Sierra are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best pet-friendly hotel in Santa Cruz?
Casa Por Temporadas is a top dog-friendly guesthouse, and offers an outdoor pool along with in-room kitchens for its human guests. Other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Yotau All Suites Hotel is a top hotel with 2 outdoor pools, a children's pool, and 2 restaurants. A couple of other options that offer an onsite pool include Gran Hotel Santa Cruz and Buganvillas Hotel Suites & Spa. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness center, a hair salon, and a bar. Enjoy a facial, body scrub, or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.
What's the top hotel in Santa Cruz with an on-site water park or a water park nearby?
Gran Hotel Santa Cruz is a popular hotel featuring free water park access, an outdoor pool, and a restaurant. Check out all hotels with or near waterparks in Santa Cruz.
What's the best hotel for staying near Viru Viru International Airport (VVI)?
Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.
How is it to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 312 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Cultural venues include Ethno-folkloric Museum, Cine Center, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Arenal Park, Guembe Biocenter, and Lomas de Arena Regional Park. Check out what more to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.

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