A colonial-style building with a bell tower, palm trees, and a paved walkway.

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Check prices for these dates

Next weekend
Jul 3 - Jul 5
In two weeks
Jul 10 - Jul 12

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Our top choices for Santa Cruz hotels

Seasonal outdoor pool

1. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (381 reviews)
"Nice hotel"
United States
Mabel Marisel
The price is ￥20,484
￥20,484 total
Jul 10 - Jul 11
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Miscellaneous

2. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (124 reviews)
"Nice place"
United States
Juan Carlos
The price is ￥8,647
￥8,647 total
Jul 18 - Jul 19
Ibis Santa Cruz DE LA Sierra
Reception

3. Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (428 reviews)
"Definitely I would’ve recommend anybody who is looking for hotel because the service was excellent make me feel special since I walked in into the place and also I was impressed how clean the place was…Thanks for the service guys…Keep up this way..thanks again for everything…I’ll see you soon.🙏"
United States
Edwin
The price is ￥27,686
￥27,686 total
Jul 3 - Jul 4
Camino Real Hotel
Lounge

4. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (279 reviews)
"The hotel truly exceeded all my expectations. The quality of the facilities, the service, and the excellent breakfast were outstanding."
United States
imilse de
The price is ￥11,904
￥11,904 total
Jul 19 - Jul 20
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Lobby sitting area

5. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (118 reviews)
"REALLY NICE HOTEL. STAFF WONDERFULL"
United States
ERNESTO
The price is ￥22,175
￥22,175 total
Jul 21 - Jul 22
Novotel Santa Cruz De La Sierra
Outdoor pool, pool umbrellas, sun loungers

6. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (236 reviews)
"Amazing hotel"
United States
Deivis
The price is ￥19,761
￥19,761 total
Jul 10 - Jul 11
Marriott Santa Cruz de la Sierra Hotel
Outdoor pool, sun loungers

7. Hotel Cortez

Hotel Cortez
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (144 reviews)
"Lovely hotel. Great room, location, staff and amenities. "
Norway
Solvei Emily Brekke
The price is ￥16,728
￥16,728 total
Jul 5 - Jul 6
Hotel Cortez
Outdoor pool

8. Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (381 reviews)
"Very well located three start hotel. Clean with everything you need for an in/out night. Hotel needs a redoing."
United States
jose
The price is ￥17,467
￥17,467 total
Jul 2 - Jul 3
Sun Hotel
Front of property

9. Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (68 reviews)
"Clean room and friendly staff "
United States
marcia
The price is ￥8,734
￥8,734 total
Jun 28 - Jun 29
Chairú Eco Hotel
Massages

10. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (87 reviews)
"Great room, spacious, quiet and the shower was great"
United States
GONZALO
The price is ￥16,278
￥16,278 total
Jul 11 - Jul 12
Swissôtel Santa Cruz De La Sierra
Daily buffet breakfast for a fee

11. Hotel LP Equipetrol

Hotel LP Equipetrol
3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (209 reviews)
"Nice place to stay"
United States
Ricardo
The price is ￥6,352
￥7,161 total
Jul 3 - Jul 4
Hotel LP Equipetrol
Exterior detail

12. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (166 reviews)
"My go too hotel whenever I'm in town! "
United States
Pluetina
The price is ￥15,867
￥15,867 total
Jun 29 - Jun 30
TRYP by Wyndham Santa Cruz
Massages

13. Yotau All Suites Hotel

Yotau All Suites Hotel
3.5 star property
Santa Cruz
7.0 out of 10, Good, (76 reviews)
"I like everything "
United States
Sebastián
The price is ￥18,196
￥18,196 total
Jul 28 - Jul 29
Yotau All Suites Hotel
Outdoor pool

14. Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (95 reviews)
"Great location, nice and quiet neighborhood."
United States
ALEJANDRO
The price is ￥8,574
￥8,574 total
Jun 28 - Jun 29
Delfines Collection Hotel By Mercure
Honeymoon Room, 1 King Bed | Egyptian cotton sheets, premium bedding, pillowtop beds, minibar

15. HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (51 reviews)
"Room was great and staff were very accommodating!"
Canada
David
The price is ￥7,546
￥9,972 total
Jun 29 - Jun 30
HOTEL OSHO
Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers

16. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (108 reviews)
"Great Location"
United States
Blanca
The price is ￥6,622
￥6,622 total
Jul 1 - Jul 2
Premium Suites Deluxe Aparthotel Equipetrol
Reception

17. Lido Hotel

Lido Hotel
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (44 reviews)
"Lovely stay for a night. Great location within easy walking distance to the center."
United States
Gabrielle
The price is ￥6,073
￥6,073 total
Jun 28 - Jun 29
Lido Hotel
Restaurant

18. Prince Hotel

Prince Hotel
3.0 star property
Santa Cruz
8.8 out of 10, Excellent, (6 reviews)
"Nice place "
United States
Marco
The price is ￥5,434
￥8,183 total
Jul 10 - Jul 11
Prince Hotel
Front of property

19. Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (44 reviews)
"Beautiful place, wonderful artwork"
United States
Elizabeth
The price is ￥17,437
￥17,437 total
Jun 29 - Jun 30
Alfonsina Hotel Boutique by Inboccaluppo
Standard Room, 2 Twin Beds | Premium bedding, minibar, in-room safe, desk

20. Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro
3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (285 reviews)
"Awesome hotel "
Canada
John
The price is ￥7,860
￥8,669 total
Jul 3 - Jul 4
Hotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Vacation Rentals in Santa Cruz

Aparthotel
Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (108 reviews)
"Great Location"
Premium Suites Deluxe Aparthotel Equipetrol
See all vacation rentals
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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Ventura Mall are some notable places to visit nearby.

Stay near popular Santa Cruz attractions

Plaza 24 de Septiembre

8.8/5 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
See properties

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A colonial-style building with a bell tower, palm trees, and a paved walkway.

Top Santa Cruz Hotel Reviews

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

10/10 Excellent
"Good Hotel, nice to walk and Good Restaurants. In my room they have a problem with the design of the bathroom that they have to take care."
Luis 5-night trip
Posted 8 hours ago
TRYP by Wyndham Santa Cruz

More cheap stays in Santa Cruz

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

Equipetrol Santa Cruz Departamento de Santa Cruz
The price is ￥7,958 per night from Jun 29 to Jun 30
￥7,958
￥7,958 total
Jun 29 - Jun 30

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is one of the top choices for your stay based on our traveler data. This hotel offers a restaurant and free parking. Other good choices for your visit include Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other homes for rent in Santa Cruz include Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Ibiza Hostel and Residencial Ikandire II. View all budget hotels in Santa Cruz.
What's the best accommodation for a family trip to Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.
What is the top LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best pet-friendly hotel in Santa Cruz?
Casa Por Temporadas is a top dog-friendly guesthouse, and offers an outdoor pool along with in-room kitchens for its human guests. Other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Novotel Santa Cruz De La Sierra are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Yotau All Suites Hotel is a top hotel with 2 outdoor pools, a children's pool, and 2 restaurants. A couple of other options that offer an onsite pool include Buganvillas Hotel Suites & Spa and Loft sobrio, rooftop panorámico y piscina infinita. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness center, a hair salon, and a bar. Enjoy a facial, body scrub, or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.
What's the best hotel for staying near Viru Viru International Airport (VVI)?
Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.
How is it to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 290 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Cultural venues include Ethno-folkloric Museum, Cine Center, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Arenal Park, Guembe Biocenter, and Lomas de Arena Regional Park. Check out what more to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.