A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Mytilene Vacation Rentals

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Check prices for these dates

In two weeks
Oct 9 - Oct 11
In two months
Nov 20 - Nov 22
In three months
Dec 18 - Dec 20
In four months
Jan 15 - Jan 17

Our top choices for Mytilene vacation rentals

A pathway flanked by lush greenery and palm trees, leading to a distant structure.

1. Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very good, (91 reviews)
"Lovely mansion house and a great breakfast."
United States
Malcolm
The price is ￥14,340
￥17,511 total
includes taxes & fees
Oct 11 - Oct 12
Loriet Hotel
A hotel room with two beds, a desk, and a view of the ocean.

2. Akti Vigla Premium

Akti Vigla Premium
Lesvos
10.0 out of 10, Exceptional, (19 reviews)
"Very clean room, excellent easy check in. Easy to find and free parking. Perfect location close to the airport. Ocean view."
United States
Gertrud
The price is ￥11,937
￥13,436 total
includes taxes & fees
Oct 25 - Oct 26
Akti Vigla Premium
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

3. Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (36 reviews)
"Beautiful quiet nice little place.Very cosy !!"
Australia
Anonymous traveler
The price is ￥21,095
￥23,469 total
includes taxes & fees
Oct 5 - Oct 6
Elies Residences
A hotel room with a bed, a nightstand with a lamp, a view of the city through the window, and a painting on the wall.

4. Your refuge overlooking port

Your refuge overlooking port
Mytilene
The price is ￥14,244
￥20,575 total
includes taxes & fees
Sep 25 - Sep 26
Your refuge overlooking port
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

5. Villa PETRA

Villa PETRA
ΜΥΤΙΛΗΝΗ
10.0 out of 10, Exceptional, (1 review)
"Rena and Anna were very helpful and friendly. The property had very high standards. We stayed there for a week. Breakfast can be ordered to room with a fee. We ordered a chicken pancake for €7.2 which came in 4 pieces, it was large enough for 2 people. There is a place called Istoriko at seaside within 10min walk which serves food&coctails we liked it so much. Cab costs €8, local bus €2 if you want to go to the city centre. I highly recommend this villa."
United Kingdom
Yigit
The price is ￥27,027
￥30,811 total
includes taxes & fees
Oct 1 - Oct 2
Villa PETRA
A bedroom with a wooden bed, a blue bedspread, a wall-mounted lamp, a painting of a sunset, and a small bedside table with a lamp.

6. Experience Comfort in our Newly Remodeled 5A

Experience Comfort in our Newly Remodeled 5A
Mitilini
2.0 out of 10, (1 review)
The price is ￥15,827
￥22,316 total
includes taxes & fees
Sep 26 - Sep 27
Experience Comfort in our Newly Remodeled 5A
A compact living space with a dining area, kitchenette, and a sofa.

7. The Heart of Mytilene

The Heart of Mytilene
Mitilini
The price is ￥11,351
￥14,594 total
includes taxes & fees
Sep 28 - Sep 29
The Heart of Mytilene
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

8. Villa SIGRI

Villa SIGRI
MYTILENE
The price is ￥27,027
￥30,811 total
includes taxes & fees
Oct 1 - Oct 2
Villa SIGRI
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

9. Villa ERESOS

Villa ERESOS
ΜΥΤΙΛΗΝΗ
The price is ￥27,027
￥30,811 total
includes taxes & fees
Oct 1 - Oct 2
Villa ERESOS
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

10. Villa SYKAMIA

Villa SYKAMIA
ΜΥΤΙΛΗΝΗ
The price is ￥27,027
￥30,811 total
includes taxes & fees
Oct 1 - Oct 2
Villa SYKAMIA
A coastal area with a beach, boats, and buildings.

11. Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos

Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos
Agiasos
The price is ￥35,135
￥41,982 total
includes taxes & fees
Sep 25 - Sep 26
Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos
A two-story building with a white facade and stone exterior.

12. Gianni's House

Gianni's House
Polichnitos
10.0 out of 10, Exceptional, (1 review)
"A nice, quiet, comfy and simple place. I felt welcomed. The village is the same. I really enjoyed it."
Canada
Jean-Philippe
The price is ￥10,811
￥13,730 total
includes taxes & fees
Oct 2 - Oct 3
Gianni's House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mytilene Hotel Reviews

Akti Vigla Premium

Akti Vigla Premium

10/10 Excellent
"Breakfast was fantastic and we loved the engineering of the patio doors. They tilt and open"
Rebecca 1-night trip
Posted 10 days ago
Akti Vigla Premium

Find out more about Mytilene

Search for holiday rentals in Mytilene on Expedia! You can easily find your home rentals, villas, holiday apartments in Mytilene using one of the methods below:

  • View our selection of featured holiday rentals in Mytilene
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  • Enter your travel dates to view the best deals on holiday rentals in Mytilene while they last

Look no further and take a look at our great range of rental properties in Mytilene!

Frequently asked questions

Are there vacation rentals in Mytilene?

Yes, we give you a choice of vacation rentals close to the most popular attractions in Mytilene, or you can select a more remote option if you want a relaxing place to stay. Nature enthusiasts will enjoy the seaside in Mytilene. Make sure you have time to check out the museums and monuments during your trip.

What's the top vacation rental that Mytilene has to offer?

Mikos - Mansion in the City Center: This highly rated vacation home rental in Mytilene is located on the beach and has a garden, a barbecue grill, and free WiFi to put you at ease in your new surroundings. Some other homes for rent in Mytilene include V House Cozy & Quiet Escape and Villa Laurette Kratigos, Private Escape with Views.

How many vacation rentals will I find in Mytilene?

Choose from 15 Expedia vacation rentals in Mytilene for a memorable vacation.

What’s there to see and do in Mytilene?

Enjoy the outdoors at Thermes Gera Hot Springs and Thermi Beach, or simply take in cultural attractions like Ecclesiastical Byzantine Museum and Theriade Library and Museum of Modern Art. While here, Port of Mytilene and Mytilini Castle are other places worth a visit.

What’s a vacation rental in Mytilene like?

A vacation rental is a private property you can stay in for a couple of days or more in Mytilene. Vacation rentals provide amenities such as kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive choice for family trips.