Mississippi County Vacations & Trips

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Mississippi County Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
The price is ￥9,544 per night from Jul 12 to Jul 13
￥9,544
￥10,591 total
Jul 12 - Jul 13
includes taxes & fees
6.6/10 (641 reviews)
"The outside of the hotel needs some work The breakfast needed more than instant oatmeal for breakfast. Muffins wrapped separately would have been nice. Banana along with the apples. Cold cereals in little bowls. Just anything more than what they had."

Reviewed on Jun 11, 2026

Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Fully refundableReserve now, pay when you stay
The price is ￥12,031 per night from Jun 20 to Jun 21
￥12,031
￥13,351 total
Jun 20 - Jun 21
includes taxes & fees
6.8/10 (416 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."

Reviewed on Jun 7, 2026

The Riverstone Hotel Charleston-Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is ￥17,665 per night from Jun 21 to Jun 22
￥17,665
￥20,310 total
Jun 21 - Jun 22
includes taxes & fees
9.6/10 Exceptional! (1,000 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

Drury Inn & Suites Sikeston, MO
See all 111 properties in Mississippi County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mississippi County vacation package cost?
The most affordable Mississippi County package is , so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your traveling style.
How do I get a cheap travel package to Mississippi County?
You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County vacation package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination.
What are the top hotels in Mississippi County?
East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up Super 8 by Wyndham Charleston MO and Quality Inn Charleston I-57.
How far in advance should I book my Mississippi County vacation?
Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure.
What does an Expedia Mississippi County travel package include?
That depends on what you're looking for. If you're traveling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package.
What should I know before booking a Mississippi County travel package?
You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organizing a luxury romantic escape or a budget solo adventure, explore our vacation packages today.
Can I choose my airline with a Mississippi County Expedia vacation package?
Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organizing your Mississippi County adventure.
If I'm not able to travel, can I cancel my Mississippi County vacation package?
Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County vacation package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Stay near popular Mississippi County attractions

Big Oak Tree State Park

8.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.