A bridge over a muddy river with green trees and hills in the background.

Vacation Rentals in Mississippi County

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Our top choices for Mississippi County vacation rentals

A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

1. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ￥23,448
￥45,713 total
includes taxes & fees
Oct 1 - Oct 2
Quiet Country Stay: Modern Home Near Paducah
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

2. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (37 reviews)
"Great place in a beautiful location. "
United States
George B.
The price is ￥19,829
￥31,690 total
includes taxes & fees
Oct 1 - Oct 2
Peaceful secluded cabin located near Horseshoe Lake
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

3. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
10.0 out of 10, Exceptional, (4 reviews)
"Host was great. "
United States
Sheila C.
The price is ￥17,153
￥46,333 total
includes taxes & fees
Oct 1 - Oct 2
Quiet Country Stay: Modern Home Near Paducah
A hot tub in an outdoor setting with a wooden deck and lounge chairs.

4. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
The price is ￥19,309
￥29,344 total
includes taxes & fees
Oct 1 - Oct 2
Perfect Couples Retreat - firepit
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

5. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (43 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
The price is ￥17,704
￥22,099 total
includes taxes & fees
Oct 4 - Oct 5
Cozy cabins on beautiful Horseshoe Lake
A covered outdoor seating area with stone flooring and chairs, a stone pathway, and a wooden structure.

6. Vacation rental attached to our house out in the country.

Vacation rental attached to our house out in the country.
Union City
10.0 out of 10, Exceptional, (7 reviews)
"The home was spotless, very comfortable and a great location for what we needed."
United States
Sherrie S.
The price is ￥15,737
￥25,524 total
includes taxes & fees
Oct 2 - Oct 3
Vacation rental attached to our house out in the country.
A small, single-story building with a wooden exterior and large windows.

7. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is ￥17,704
￥22,099 total
includes taxes & fees
Oct 5 - Oct 6
The Rested Duck Mallard Room
A modern kitchen with a built-in microwave, stainless steel appliances, and a sink.

8. Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
10.0 out of 10, Exceptional, (26 reviews)
"Location was great. Beds were so comfortable, place was so clean and nice. Very cute place to stay. Would stay here again!"
United States
Deannena H.
The price is ￥17,311
￥32,485 total
includes taxes & fees
Oct 5 - Oct 6
Charming Home just minutes from Interstate and Mall
A wooden interior with a herringbone floor, a sliding barn door, a wooden door with a glass panel, and a window with blinds.

9. Tiny house on the lake with tv free internet walk shower

Tiny house on the lake with tv free internet walk shower
Tiptonville
10.0 out of 10, Exceptional, (1 review)
"Dave was very accommodating and the home was clean."
United States
Katherine P.
The price is ￥28,327
￥48,533 total
includes taxes & fees
Oct 5 - Oct 6
Tiny house on the lake with tv free internet walk shower
A kitchen with wooden cabinets, a stainless steel stove, and a wall-mounted sign.

10. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
The price is ￥22,504
￥32,731 total
includes taxes & fees
Oct 3 - Oct 4
The Roost | Hot Tub, Ponds & Farm Views
A room with a pool table, a sofa, and a dining table with chairs.

11. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (3 reviews)
"The location is lovely and peaceful. The cabin is clean, comfortable and relaxing. We enjoyed the pool table and ping pong."
United States
Michelle U.
The price is ￥28,327
￥42,029 total
includes taxes & fees
Oct 2 - Oct 3
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
A bedroom with a bed, a nightstand, a bedside table, a floor lamp, a ceiling fan, and a sliding door leading to a bathroom.

12. Welcoming 4-bedroom house with AC in charming La Center

Welcoming 4-bedroom house with AC in charming La Center
La Center
10.0 out of 10, Exceptional, (2 reviews)
"We stayed here while working on a project, and it was honestly one of the best stays I’ve had. The house was super clean, the beds were very comfortable, and the air conditioning worked great. The neighborhood felt safe, the neighbors were friendly, and the location was very convenient with a grocery store just a couple blocks away and a great pizza place nearby.I would definitely stay here again. Highly recommend!"
United States
Tom R.
Welcoming 4-bedroom house with AC in charming La Center
A single-story house with a gabled roof, a front porch with two chairs, and a front door with a decorative glass panel.

13. Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid
10.0 out of 10, Exceptional, (1 review)
"The host was very quick to respond and so great to work with for on our stay. "
United States
Jessica S.
The price is ￥31,474
￥58,019 total
includes taxes & fees
Oct 12 - Oct 13
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
A covered outdoor area with a grill, chairs, and a table.

14. Come and relax at the Refuge at beautiful Reelfoot Lake!

Come and relax at the Refuge at beautiful Reelfoot Lake!
Hornbeak
9.4 out of 10, Exceptional, (37 reviews)
The price is ￥20,537
￥38,351 total
includes taxes & fees
Oct 5 - Oct 6
Come and relax at the Refuge at beautiful Reelfoot Lake!
A kitchen with a stainless steel stove, a range hood, wooden cabinets, and a herringbone wood backsplash.

15. Charming 3-bedroom house with free wifi and coffee it is close to the lake

Charming 3-bedroom house with free wifi and coffee it is close to the lake
Hornbeak
10.0 out of 10, Exceptional, (11 reviews)
"This place was great! It has everything you need and the neighborhood was quiet. The beautiful view of the lake makes it very peaceful! "
United States
Jamie M.
The price is ￥24,786
￥43,656 total
includes taxes & fees
Oct 11 - Oct 12
Charming 3-bedroom house with free wifi and coffee it is close to the lake
A large, single-story building with two open garage-style doors, surrounded by trees with autumn foliage.

16. Guest house and spacious shop located between Discovery Park and Reelfoot Lake

Guest house and spacious shop located between Discovery Park and Reelfoot Lake
Union City
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful place to relax. Home has everything you need. The additional party barn is an added bonus!!"
United States
william P.
The price is ￥39,657
￥60,671 total
includes taxes & fees
Oct 1 - Oct 2
Guest house and spacious shop located between Discovery Park and Reelfoot Lake
A covered patio with a white bench, a glass table, and a fan.

17. Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR

Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR
Hornbeak
9.8 out of 10, Exceptional, (63 reviews)
"Very clean and very helpful host"
United States
Whitney C.
The price is ￥26,202
￥45,739 total
includes taxes & fees
Oct 7 - Oct 8
Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR
A kitchen with wooden cabinets, a stainless steel refrigerator, a built-in oven, and a large window.

18. 3-bedroom house in charming Tiptonville with cool AC and washer and dryer

3-bedroom house in charming Tiptonville with cool AC and washer and dryer
Tiptonville
10.0 out of 10, Exceptional, (1 review)
"Easy to get along with and great communication. "
United States
Shane W.
The price is ￥21,245
￥37,185 total
includes taxes & fees
Oct 6 - Oct 7
3-bedroom house in charming Tiptonville with cool AC and washer and dryer
A small, single-story mobile home with a covered porch and a sign that reads "THE HUT".

19. The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed

The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed
Hornbeak
9.8 out of 10, Exceptional, (60 reviews)
"Great place to stay! Clean and convenient location what more can you ask for! "
United States
Austin E.
The price is ￥19,671
￥38,261 total
includes taxes & fees
Oct 4 - Oct 5
The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed
A compact RV interior with a kitchenette, a seating area, and a window providing a view outside.

20. Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.

Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
La Center
The price is ￥7,082
￥15,163 total
includes taxes & fees
Oct 1 - Oct 2
Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent
"Everything"
James 1-night trip
Posted 1 day ago
Holiday Inn Express & Suites Sikeston Southwest by IHG

Find out more about Mississippi County

Vacation Apartments in Mississippi County

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