Find hotels in Mission Bay, San Diego from ￥19,819

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 17 - Dec 18
Tomorrow
Dec 18 - Dec 19
This weekend
Dec 19 - Dec 21
Next weekend
Dec 26 - Dec 28

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mission Bay hotels

Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1573)
"Loved our stay "
United States
Jeremy
The price is ￥19,810
￥30,973 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hyatt Regency Mission Bay Spa and Marina
Outdoor pool, open 7:00 AM to 10:00 PM, cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1311)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is ￥19,386
￥29,271 total
includes taxes & fees
Dec 18 - Dec 19
San Diego Mission Bay Resort
2 outdoor pools, a heated pool, sun loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay
9.0 out of 10, Wonderful, (3929)
"Always love staying here. Staff was very courteous and the rooms very clean. "
United States
Eric
The price is ￥21,513
￥27,823 total
includes taxes & fees
Dec 21 - Dec 22
The Dana on Mission Bay
Property grounds
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay
8.6 out of 10, Excellent, (2355)
"Great stay, top tier service and excellent customer care "
Canada
Meriem
The price is ￥20,019
￥31,201 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Paradise Point Resort & Spa
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
8.2 km from Mission Bay
8.8 out of 10, Excellent, (742)
"Friendly staff and clean rooms. "
Canada
Justine
The price is ￥16,591
￥19,237 total
includes taxes & fees
Dec 23 - Dec 24
The DEXTRO Little Italy, BW Premier Collection
Outdoor pool, sun loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 10 km from Mission Bay
8.6 out of 10, Excellent, (1869)
"Enjoyed my stay"
United States
Brandon
The price is ￥16,251
￥26,435 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton San Diego Bayfront
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
8 km from Mission Bay
8.4 out of 10, Very Good, (6030)
"Always an amazing stay"
United States
Jana
The price is ￥20,917
￥28,740 total
includes taxes & fees
Dec 21 - Dec 22
Wyndham San Diego Bayside
Suite, 1 King Bed with Sofa Bed (Marina Tower Newly Renovated Marina view) | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
6 km from Mission Bay
8.4 out of 10, Very Good, (3159)
"Great stay! "
United States
Melissa
The price is ￥16,444
￥24,473 total
includes taxes & fees
Dec 22 - Dec 23
Sheraton San Diego Resort
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 9.4 km from Mission Bay
9.4 out of 10, Exceptional, (1000)
"Great location "
United States
Mohammad
The price is ￥13,229
￥19,819 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
8.5 km from Mission Bay
8.6 out of 10, Excellent, (1065)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is ￥20,925
￥28,748 total
includes taxes & fees
Dec 23 - Dec 24
The Westin San Diego Bayview
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
8.7 km from Mission Bay
8.6 out of 10, Excellent, (1454)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 9.2 km from Mission Bay
9.2 out of 10, Wonderful, (1951)
"Amazing stay. Absolutely perfect "
United States
Wayne
The price is ￥24,608
￥36,670 total
includes taxes & fees
Dec 23 - Dec 24
Marriott Marquis San Diego Marina
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
2.6 km from Mission Bay
7.4 out of 10, Good, (4116)
"Room was very clean and staff very pleasant "
Canada
Brian
The price is ￥13,086
￥15,041 total
includes taxes & fees
Dec 23 - Dec 24
Wyndham Garden San Diego Near SeaWorld
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
7 km from Mission Bay
8.8 out of 10, Excellent, (1560)
"Staff was great, easy check in and great location"
United States
Alysa
The price is ￥17,706
￥20,352 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Best Western Plus Island Palms Hotel & Marina
Courtyard
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley, 17.8 km from Mission Bay
8.4 out of 10, Very Good, (1893)
"Excellent location"
United States
Paolo
The price is ￥15,780
￥17,981 total
includes taxes & fees
Jan 4 - Jan 5, 2026
DoubleTree by Hilton San Diego - Del Mar
Exterior
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 9 km from Mission Bay
9.0 out of 10, Wonderful, (2870)
"Great Location....tons of walking from the hotel Front desk were very nice and polite will be coming back for sure "
United States
Carlos
The price is ￥27,240
￥40,017 total
includes taxes & fees
Dec 18 - Dec 19
Manchester Grand Hyatt San Diego
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
6.8 km from Mission Bay
9.2 out of 10, Wonderful, (3193)
"Great stay and location!"
United States
Jason
The price is ￥18,973
￥21,809 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Bay Club Hotel & Marina
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
4.3 km from Mission Bay
8.8 out of 10, Excellent, (1290)
"Hotel was very clean and the staff was very friendly"
United States
Norma
The price is ￥15,480
￥17,794 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hampton Inn San Diego/Mission Valley
Exterior
Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 4 km from Mission Bay
8.2 out of 10, Very Good, (1915)
"Efficient check in, clean rooms and great breakfast."
Canada
Wendy
The price is ￥11,763
￥13,521 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn San Diego Old Town
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 9.6 km from Mission Bay
9.0 out of 10, Wonderful, (1230)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is ￥21,216
￥24,598 total
includes taxes & fees
Dec 20 - Dec 21
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Mission Bay

Find the best Mission Bay areas and neighborhoods for the activities you enjoy most.
US Grant Hotel

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Pacific Beach Park showing a beach

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Belmont Park showing rides and a garden

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Ocean Beach

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Mission Bay Hotel Reviews

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

10/10 Excellent
"Wonderful and polite staff great amenities and food Valet service like we never experienced before. Hard Rock hotel is definitely on my trip Calendar. "
David 3-night trip
Posted 11 hours ago
Hard Rock Hotel San Diego

Explore a world of travel with Expedia

Frequently asked questions

What is Mission Bay like?
You'll be sure to have fun visiting San Diego's Mission Bay neighborhood. Looking for sights you might find in a travel guide about Mission Bay? Consider a visit to Mission Bay while you're in the neighborhood.
What's a favorite hotel to stay in Mission Bay?
Based on Expedia customer reviews, Paradise Point Resort & Spa is the highest ranked property in Mission Bay. This resort offers a marina and 5 outdoor pools. Other favorite options in the area include The Dana on Mission Bay and San Diego Mission Bay Resort.
How many hotels should I expect to find in Mission Bay?
If you're searching for places to stay in San Diego, Expedia has something to meet your needs with 46 Mission Bay hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Mission Bay, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to view the best options available in Mission Bay.
Where can I learn more about changing or cancelling my trip to Mission Bay?
To find more details about updating your trip to Mission Bay or cancelling it, head over to our customer service page.
What is there to do around this San Diego neighborhood?
Enjoy a stroll along the shore at Mission and Pacific Beaches, Ski Beach, and Crown Point Shores while you're in Mission Bay. You could also plan a visit to Mission Bay or Mission Bay Golf Course while you're in the neighborhood. Mission Beach and Hotel Circle are some favorite places to visit in the area around Mission Bay. When you're sightseeing in San Diego, North Cove Beach and Bahia Point Beach are also worth a stop.