Find hotels in Mesopotamia from ¥7,581

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Compare 43 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Mesopotamia hotels

To Spiti tis Sofias

10.0 out of 10, Exceptional, (1)
"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin. "
The price is ¥9,824
¥11,500 total
includes taxes & fees
Sep 8 - Sep 9
To Spiti tis Sofias

Limneon Resort & Spa

4.0 star property
9.2 out of 10, Wonderful, (189)
"Wonderful stay. "
The price is ¥13,183
¥16,693 total
includes taxes & fees
Aug 26 - Aug 27
Limneon Resort & Spa

Chloe Hotel

3.0 star property
10.0 out of 10, Exceptional, (84)
"We enjoyed the stay, friendly staff and nice breakfast "
The price is ¥15,162
¥18,078 total
includes taxes & fees
Aug 26 - Aug 27
Chloe Hotel

Esperos Palace Luxury & Spa Hotel

4.0 star property
9.0 out of 10, Wonderful, (83)
"Gorgeous and spacious. Very classy and modern. I've stayed here twice and will definitely go back. "
The price is ¥15,211
¥18,996 total
includes taxes & fees
Aug 26 - Aug 27
Esperos Palace Luxury & Spa Hotel

Calma Hotel & Spa

4.0 star property
9.6 out of 10, Exceptional, (34)
"Great place to relax. Very kind staff all over. Nice breakfast buffet."
Calma Hotel & Spa

Hotel Anastassiou

2.0 star property
8.0 out of 10, Very Good, (67)
"Nice hotel. Nice room. Nice people!! Not walkable to town but a very short drive! And a very lovable property pup!! Thank you for your hospitality!! "
The price is ¥7,581
¥8,954 total
includes taxes & fees
Aug 26 - Aug 27
Hotel Anastassiou

Orologopoulos Mansion

5.0 star property
9.6 out of 10, Exceptional, (33)
"Wonderful Boutique hotel in center of old town"
Orologopoulos Mansion

Kyknos De Luxe Hotel

10.0 out of 10, Exceptional, (42)
"Very nice clean, very polite staff and great breakfast!"
The price is ¥12,887
¥15,497 total
includes taxes & fees
Aug 27 - Aug 28
Kyknos De Luxe Hotel

Guesthouse Vissinokipos

9.4 out of 10, Exceptional, (10)
"Wonderfull view and very friendly people.the place is avery dpecial artistic decorated.wonderfull weather.nice varieties for breakfast.price was ver good.i recommend it!"
Guesthouse Vissinokipos

Arhontiko Christodoulou

2.0 star property
Arhontiko Christodoulou

Guest House Ilektra

9.8 out of 10, Exceptional, (6)
"A fantastic experience. Don't hesitate to stop at Ilektra Guest House. People are delicious, the diner was perfect with a lot of mushrooms they got in the mountains during the day. A fabulous place !!! Thanks again to our guests"
The price is ¥7,581
¥8,953 total
includes taxes & fees
Aug 26 - Aug 27
Guest House Ilektra

Anesis Hotel

2.0 star property
9.0 out of 10, Wonderful, (9)
"Fantastic hotel in the heart of Kastoria. The owners are lovely people, very helpful and made me feel right at home. Will definitely stay there again!"
The price is ¥8,339
¥9,814 total
includes taxes & fees
Aug 26 - Aug 27
Anesis Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Mesopotamia attractions

Dragon's Lair

Dragon's Lair

Explore the great outdoors at Dragon's Lair, a lovely green space in Kastoria. While you're in the area, stroll along the lakeside.

Learn more about Mesopotamia

Head to Kastoria Lake and Dragon's Lair—just two of the sights around Mesopotamia.

Top Mesopotamia Hotel Reviews

More cheap stays in Mesopotamia

More cheap stays in Mesopotamia

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where is the best place for a stay in Mesopotamia?

To Spiti tis Sofias is one of the top choices for your stay based on our traveler data. This guesthouse offers free parking and free WiFi. Two other choices for your visit to the area are Limneon Resort & Spa and Hotel Anastassiou. See all available top hotels, or vacation rentals in Mesopotamia.

What are some of the best vacation home rentals that Mesopotamia has to offer?

The Little Stone House by the Lake / Το Πέτρινο Σπιτάκι δίπλα στη Λίμνη: This vacation home rental outside of Mesopotamia is located on a lake and has a fireplace, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, an oven, and a microwave. See all vacation rentals in Mesopotamia.

If I need to cancel my hotel reservation in Mesopotamia, will I receive a refund?

Yes! You'll find that most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Mesopotamia.

Where can I learn more about changing or cancelling my trip to Mesopotamia?

For more details about picking new dates or cancelling your trip to Mesopotamia, click here.

What is the best accommodation for staying close to Macedonia Airport (SKG)?

Hyatt Regency Thessaloniki is a popular 5-star hotel featuring 2 outdoor pools and a full-service spa. It's located a short 1.1 mi (1.8 km) from Macedonia Airport. Other options near the airport are Athina Airport Hotel and Hotel Nikopolis.

What is staying in Mesopotamia like?

Travelers to Mesopotamia will find plenty to explore and enjoy. There are 44 hotels and other accommodations in the surrounding area. Find out more about Mesopotamia.

What are the top places to visit in Mesopotamia?

Places to visit in the wider area include Kastoria Lake, Dragon's Lair, and Holy Monastery of Panagias Mauriotissas. You'll also find Folklore Museum of Kastoria and Holy Prophet Elias Church in the area. Check out what more to see and do in Expedia's Mesopotamia guide.

What's the seasonal weather like in Mesopotamia?

The hottest months are usually August and July with an average temp of 69°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Mesopotamia is 28 inches.