A storefront with a sign reading "The Beach Club" and various clothing items displayed in the window.

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Oct 21 - Oct 22
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Oct 22 - Oct 23
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Our top choices for Main Street Hyannis hotels

A multi-story hotel with balconies, a flat roof, and a clear sky.
A reception area with a counter, a seated area with a lamp, and framed pictures on the wall.
An indoor swimming pool with clear water, surrounded by black chairs and tables.
A man sitting at a table with a laptop, overlooking a pool area with chairs and tables.

1. Hyannis Travel Inn

Hyannis Travel Inn
0.2 km from Main Street Hyannis
United States
Colleen
￥15,659
￥17,921 total
includes taxes & fees
Oct 28 - Oct 29
Hyannis Travel Inn
A neatly arranged bedroom with a large bed, a bedside table, a chair, a TV mounted on the wall, and a window with blinds.
A two-story building with a covered porch and a sign for Sea Street Inn.
A kitchen counter with a knife and a cutting board, a sign with a flower, and a view of a dining area through glass doors.
A dining area with black leather chairs, dark wooden tables, and white bowls.

2. Sea Street Inn

Sea Street Inn
1.5 km from Main Street Hyannis
United States
John
￥41,836
￥47,881 total
includes taxes & fees
Nov 4 - Nov 5
Sea Street Inn
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.
A marina with multiple boats docked, surrounded by residential houses and greenery.
A row of wicker chairs with cushions, a map on the wall, and a view of the outside through a window.
A hotel with a pool area, outdoor seating, and a flag.

3. Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
0.6 km from Main Street Hyannis
United States
kathy
￥22,634
￥30,429 total
includes taxes & fees
Nov 2 - Nov 3
Anchor In Distinctive Waterfront Lodging
A poolside area with a wooden pergola, green seating, and a sign reading "LE JARDIN BLEU".
A bartender pouring a drink into a gold cocktail shaker.
A bar area with a patterned wall, wicker chairs, and a tiled floor.
An outdoor seating area with tables and chairs, surrounded by decorative walls and plants.

4. Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
1.9 km from Main Street Hyannis
United States
Cy
￥16,442
￥19,475 total
includes taxes & fees
Nov 2 - Nov 3
Uncommoner Hotel by Reverie Boutique Collection
A pool area with lounge chairs and flags.
A restaurant interior with tables and chairs, decorative lanterns, and potted plants.
A modern building with a sloped roof, large windows, and a covered entrance area with seating.
A sports complex with a tennis court, parking area, and buildings with multiple floors and a sloped roof.

5. The Cove at Yarmouth by Westgate Resorts

The Cove at Yarmouth by Westgate Resorts
2.1 km from Main Street Hyannis
United States
Kim
￥16,608
￥19,008 total
includes taxes & fees
Nov 8 - Nov 9
The Cove at Yarmouth by Westgate Resorts
A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.
A spacious, modern restaurant with a long counter and multiple seating areas.
A hallway with a sign reading 'ASCEND COLLECTION,' a wooden planter with plants, and a reflective floor.
An indoor swimming pool with lounge chairs, a stone wall, and a mezzanine level.

6. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel
0.3 km from Main Street Hyannis
United States
Alexandra
￥20,046
￥22,942 total
includes taxes & fees
Nov 11 - Nov 12
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
A modern conference room with a long table, chairs, a flat-screen TV, and pendant lighting.
A Fairfield by Marriott hotel with a large sign, a covered entrance, and a building with a tower.
A reception area with a wooden reception desk, a digital kiosk, and a fireplace.
A modern reception area with a desk, chairs, a fireplace, and a decorative plant.

7. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.3 km from Main Street Hyannis
United States
Joyce
￥20,032
￥22,927 total
includes taxes & fees
Oct 28 - Oct 29
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
An outdoor patio with wicker furniture, a fire pit, and umbrellas.
An indoor swimming pool with clear signage, lounge chairs, and a tiled floor.
A reception area with a sign reading "Welcome to the Patriot State" and a counter with a "Hilton" sign.
A snack and drink kiosk with a 'Treats' sign, a chalkboard menu, and shelves stocked with various snacks and beverages.

8. Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
1.7 km from Main Street Hyannis
United States
Carmen E
￥17,343
￥19,848 total
includes taxes & fees
Oct 30 - Oct 31
Hampton Inn & Suites Cape Cod-West Yarmouth
An indoor swimming pool with a high ceiling and large windows.
View from property
A modern bar area with a curved wooden counter, multiple stools, and a display case with beverages.
A hotel reception area with a digital display showing today's weather and this week's forecast.

9. Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
1.7 km from Main Street Hyannis
United States
SHREYASI
￥19,499
￥22,316 total
includes taxes & fees
Nov 20 - Nov 21
Courtyard By Marriott Cape Cod Hyannis
An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.
A hotel room with a bed, a chair, a table with two glasses of wine, a lamp, and a window with a view of a lake.
A two-story building with a prominent tower, large windows, and a well-lit entrance.
A beach scene with a directional signpost and beach chairs.

10. Bayside Resort Hotel

Bayside Resort Hotel
2.3 km from Main Street Hyannis
United States
Lynn
￥14,077
￥18,283 total
includes taxes & fees
Nov 16 - Nov 17
Bayside Resort Hotel
An indoor swimming pool with a brick wall, a white table with chairs, and a large window.
A reception area with a reception desk, a clock, a fire alarm, and a sign for the courtyard resort.
A compact hotel room with a kitchenette, a bed, a dining area, and a view through a large window.
A Courtyard Resort sign, a building with a brick facade, and a parking lot.

11. Courtyard Resort

Courtyard Resort
0.3 km from Main Street Hyannis
United States
chris
￥17,078
￥19,546 total
includes taxes & fees
Oct 27 - Oct 28
Courtyard Resort
An outdoor patio with round tables and chairs, a fire pit, and a covered seating area with string lights.
A large indoor swimming pool with multiple lanes, surrounded by rows of chairs and a high ceiling with large windows.
A lobby with a stone wall, a TV, and seating areas.
A DoubleTree hotel with a brick facade and a large sign.

12. Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
0.9 km from Main Street Hyannis
Canada
Tammie
￥17,612
￥20,156 total
includes taxes & fees
Oct 30 - Oct 31
Doubletree by Hilton Cape Cod - Hyannis
An outdoor seating area with wooden furniture and a fire pit, surrounded by trees and a gravel path.
A neatly made bed with white linens, a painting of a sailboat on the wall, and a door leading to a balcony.
A decorative shark sculpture with the text "Cape Sands Inn" at a beachside location.
A lobby with a wooden floor, a reception desk, a large window, and a ceiling fan.

13. Cape Sands Inn

Cape Sands Inn
1.9 km from Main Street Hyannis
United States
Jerome
￥10,697
￥12,242 total
includes taxes & fees
Oct 23 - Oct 24
Cape Sands Inn
A gym with various cardio and strength training equipment, including treadmills, elliptical machines, and weight machines.
A spacious, modern interior with a high ceiling, a seating area with sofas, a desk with a computer, and a large TV screen.
An indoor swimming pool with clear blue water, wooden beams on the ceiling, and lounge chairs along the poolside.
A hotel room with a gray sofa, a television on a stand, a sliding door, a framed picture on the wall, and a lamp on a side table.

14. Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
2.9 km from Main Street Hyannis
United States
Alexander
￥19,297
￥22,086 total
includes taxes & fees
Oct 30 - Oct 31
Holiday Inn Hyannis by IHG
A long dining table with chairs, a kitchen area, and a large window.
A hotel room with a bed, a desk with a flat-screen TV, a coffee maker, a microwave, a vacuum cleaner, and a sliding door to a balcony.
A Comfort Inn hotel with a modern facade, large glass windows, and a clear sky.
A reception area with a check-in counter, blue chairs, a waiting area, and a glass door leading to a dining area.

15. Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
0.3 km from Main Street Hyannis
United States
Susanne
￥16,731
￥19,148 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Inn Hyannis - Cape Cod
A two-story hotel with a curved facade, a balcony, and a sign indicating the lobby.
A resort pool area with multiple lounge chairs and umbrellas, a hot tub, and a large building in the background.
An outdoor seating area with wicker furniture, umbrellas, and a stone wall.
A waterfront hotel with a view of the marina and boats.

16. Hyannis Harbor Hotel

Hyannis Harbor Hotel
0.6 km from Main Street Hyannis
United States
N.
￥19,495
￥24,545 total
includes taxes & fees
Nov 9 - Nov 10
Hyannis Harbor Hotel
A house with a brick exterior and a covered patio area.
A two-story building with a sign for Sea Breeze Inn, including contact information and a beach view.
A two-story wooden house with a white picket fence, an American flag, and a sign indicating a business on the ground floor.
A four-poster bed with a footboard, a bedside table with a lamp, a wooden bench, and a dresser with a mirror.

17. Sea Breeze Inn

Sea Breeze Inn
1.8 km from Main Street Hyannis
United States
Ann
￥12,495
￥14,300 total
includes taxes & fees
Nov 4 - Nov 5
Sea Breeze Inn
A spacious living area with a checkered floor, a wooden staircase, a sofa set, a television, and a potted plant.
A spa room with a large bathtub, a mirror, and a chandelier.
A compact, modern bathroom with a wooden vanity, a mirror, a hairdryer, and a small seating area.
A modern kitchen with white cabinets, a black countertop, and a blue rug with an anchor design.

18. Hyannis Plaza Hotel

Hyannis Plaza Hotel
0.9 km from Main Street Hyannis
United States
Kali
￥13,624
￥17,176 total
includes taxes & fees
Nov 9 - Nov 10
Hyannis Plaza Hotel
A hotel room with two beige sofas, a glass coffee table, and a flat-screen TV mounted on the wall.
A hotel room with two beds, a desk with a television, a mirror, and a bathroom visible through an open door.
A bathroom with beige tiles, a white sink, and a mirror.
A motel with multiple rooms, a parking lot, and picnic tables.

19. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area
1.5 km from Main Street Hyannis
United States
Katherine
￥12,337
￥14,121 total
includes taxes & fees
Oct 25 - Oct 26
Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area
An indoor swimming pool with clear glass walls, a metal roof, and several Adirondack chairs around the pool.
A building with a glass entrance and a covered patio area.
A dining area with a table and chairs, a sofa, a TV mounted on the wall, and a plant on a table.
A hotel room with a bed, a desk, a chair, a television, a microwave, and a refrigerator.

20. Econo Lodge West Yarmouth on Cape Cod

Econo Lodge West Yarmouth on Cape Cod
1.5 km from Main Street Hyannis
United States
Edmund
￥13,372
￥15,304 total
includes taxes & fees
Oct 25 - Oct 26
Econo Lodge West Yarmouth on Cape Cod
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Compare popular hotels close to Main Street Hyannis

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A multi-story hotel with balconies, a flat roof, and a clear sky.
Hyannis Travel Inn
9.6
Exceptional
1,018 reviews
View
A neatly arranged bedroom with a large bed, a bedside table, a chair, a TV mounted on the wall, and a window with blinds.
Sea Street Inn
9.8
Exceptional
47 reviews
View
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.
Anchor In Distinctive Waterfront Lodging
9.4
Exceptional
1,001 reviews
View
A poolside area with a wooden pergola, green seating, and a sign reading "LE JARDIN BLEU".
Uncommoner Hotel by Reverie Boutique Collection
9.2
Wonderful
386 reviews
View
A pool area with lounge chairs and flags.
The Cove at Yarmouth by Westgate Resorts
9.2
Wonderful
269 reviews
View

Top Main Street Hyannis Hotel Reviews

Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

10/10 Excellent
"Super cool and nice place to stay. They were very accommodating and friendly! Would stay again."
Cy 5-night trip
Posted 9 hours ago
Uncommoner Hotel by Reverie Boutique Collection
Hyannis Harbor Hotel

Hyannis Harbor Hotel

10/10 Excellent
"Great location, staff was extremely helpful"
N. 1-night trip
Posted 15 hours ago
Hyannis Harbor Hotel
Bayside Resort Hotel

Bayside Resort Hotel

8/10 Good
"Tub in the room was awesome. We lost power the morning we were going to check out. About 4 hours with electricity. I called the front desk 2 times. With no response. I know the front staff are not electricians but they could have acknowledged us. Over all. Good stay"
cecilia 2-night trip
Posted 15 hours ago
Bayside Resort Hotel
Cape Sands Inn

Cape Sands Inn

10/10 Excellent
"Very clean rooms with wonderful attentive staff."
Joe 1-night trip
Posted 1 day ago
Cape Sands Inn
Americas Best Value Inn & Suites Hyannis Cape Cod

Americas Best Value Inn & Suites Hyannis Cape Cod

10/10 Excellent
"Ample free parking including parking right by the office for easy check in/out with friendly, informative staff from this family run business, and free cooffee available in the office as well. The room was impeccably clean with simple furnishings, a mini fridge abd microwave and the handicapped accessible room I reserved was perfect for getting around the room and provided ample grab rails throughout the bathroom and shower/tub combo with a detachable hand held shower head and a seat area at the back of the tub set up so you could get in and out of the tub with ease. The only negative thing about this place was the bed was extremely uncomfortable with both myself and my husband waking up with major body aches we don't typically deal with but otherwise a great place to stay especially for the price and location in the heart of downtown Hyannis. The indoor pool is wonderful and they have a Hoyle lift for those with disabilities to be able to get safely in and out as well. It was too cold out to try the outdoor pool but it looked great as well."
Kristen 3-night trip
Posted 1 day ago
Americas Best Value Inn & Suites Hyannis Cape Cod
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

10/10 Excellent
"Walk to ferries and breakfast!"
Susanne 1-night trip
Posted 1 day ago
Comfort Inn Hyannis - Cape Cod
Hyannis Travel Inn

Hyannis Travel Inn

10/10 Excellent
"Great stay. Fantastic location for harbour and Hy-line and eating establishments. Accommodation was excellent and super value for money. The staff bent over backwards to help and support. I wish we’d stayed here longer and bypassed Rhode Island!"
Lindsey 3-night trip
Posted 2 days ago
Hyannis Travel Inn
Cape Cod Inn

Cape Cod Inn

10/10 Excellent
"Great location"
Robert 2-night trip
Posted 2 days ago
Cape Cod Inn
SeaCoast Inn

SeaCoast Inn

8/10 Good
"The room was clean and the bed was comfortable in room 12. It is an older hotel but it was fine for a night. There were people sleeping outside in open building next door but there were no issues or noise. We didn't feel uncomfortable."
Ronald 1-night trip
Posted 2 days ago
SeaCoast Inn

Other attractions near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)
Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.
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The Cape Cod Maritime Museum with a green sign, a white entrance, and flower planters.

Cape Cod Maritime Museum

9.0/10 (16 reviews)
You can spend an afternoon exploring the galleries in Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the seaside in this family-friendly area, or check out its seafood restaurants.
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A white church with a steeple and a sign for Saint Francis Xavier Sunday masses.

St. Francis Xavier Church

8.6/10 (58 reviews)
After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander the beautiful beaches and waterfront in this family-friendly area.
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A memorial plaque with a bust of John F. Kennedy surrounded by a stone wall.

John F. Kennedy Memorial

9.0/10 (262 reviews)
Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial.
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Hyannis Armory

Learn about the local history of Hyannis when you take a trip to Hyannis Armory. Wander the waterfront and beautiful beaches in the area.
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Hyannis Youth & Community Center

8.2/10 (22 reviews)
You can take time to visit Hyannis Youth & Community Center during your travels to Hyannis. Stroll along the beautiful beaches or visit the shops in the area.
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Zion Union Heritage Museum

6.0/10 (1 review)
You can spend an afternoon exploring the galleries in Zion Union Heritage Museum during your travels in Hyannis. Make time to visit the area's shops, or simply enjoy its seafood restaurants.
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Commotion Charters

6.0/10 (3 reviews)
Enjoy an outing to Commotion Charters during your stay in Hyannis. Attend a sporting event or simply enjoy the seafood restaurants while you're in the area.
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Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, check out the 197 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Hyannis Travel Inn is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include Hyannis Harbor Hotel and Hyannis Plaza Hotel.
How many hotels can I expect to find close to Main Street Hyannis?
Expedia has 197 hotels and other accommodations within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view top deals close to Main Street Hyannis.
Where can I learn more about changing or cancelling my trip in the area near Main Street Hyannis?
For more information about updating your stay near Main Street Hyannis or cancelling it, click here.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Centerville Historical Museum, and Edward Gorey House feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse, and West Parish Meetinghouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Veterans Memorial Park, and Dennis Pond Conservation Area are peaceful spots to stop and take in some fresh air.