Top Puerto Santa Ana Hotels from ￥4,999

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Puerto Santa Ana

Isabel

￥19,584 total

Dec 6 - Dec 7

A rooftop pool with a view of the city skyline.

2. Luxury Suites Riverfront GYE

Puerto Santa Ana

Pedro

￥13,720 total

Nov 16 - Nov 17

A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

3. River View suites Puerto Santa Ana gye

Puerto Santa Ana

Aaliyah

￥14,174 total

Nov 16 - Nov 17

A grand room with ornate chandeliers, a large mirror, and a staircase leading to another level.

4. Mansión del Río

Las Peñas, 0.6 km from Puerto Santa Ana

Shuyi

￥9,464 total

Nov 15 - Nov 16

A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

5. Hotel Río Guayas by Art Hotels Ecuador

Las Peñas, 0.6 km from Puerto Santa Ana

septimiu

￥36,583 total

Nov 15 - Nov 16

A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

6. Wyndham Garden Guayaquil

Simón Bolívar, 2.8 km from Puerto Santa Ana

Giselle

￥17,832 total

Dec 2 - Dec 3

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

7. Hotel Ramada

Downtown Guayaquil, 1.3 km from Puerto Santa Ana

Pedro

￥10,158 total

Dec 5 - Dec 6

A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

8. Oro Verde Guayaquil

Downtown Guayaquil, 2.1 km from Puerto Santa Ana

ricardo

￥15,396 total

Dec 13 - Dec 14

A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

9. Courtyard by Marriott Guayaquil

Kennedy, 2.5 km from Puerto Santa Ana

Richard

￥14,379 total

Nov 20 - Nov 21

A cocktail on a marble table with a pool in the background.

10. Hotel Patrimonial by Greenfield

Downtown Guayaquil, 1.4 km from Puerto Santa Ana

Jackson

￥7,463 total

Dec 5 - Dec 6

A modern interior with a seating area, a kitchen, and a dining space.

11. Holiday Inn Guayaquil Airport by IHG

3.7 km from Puerto Santa Ana

Iris

￥18,031 total

Nov 27 - Nov 28

An indoor pool with a waterfall, surrounded by lush tropical plants.

12. Grand Hotel Guayaquil, Centro Histórico.

Rocafuerte, 2.2 km from Puerto Santa Ana

Victor

￥13,507 total

Nov 15 - Nov 16

A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

13. Hilton Colon Guayaquil

Kennedy, 3.2 km from Puerto Santa Ana

Mayra

￥17,612 total

Nov 22 - Nov 23

An outdoor cafe with tables and chairs, surrounded by trees and buildings.

14. Fortune Hotel

River City, 1 km from Puerto Santa Ana

MARIA

￥7,309 total

Nov 24 - Nov 25

A reception desk with a marble top and a modern light fixture above it.

15. TRYP by Wyndham Guayaquil Airport

Simón Bolívar, 2.8 km from Puerto Santa Ana

MIGUEL A.

￥17,874 total

Dec 6 - Dec 7

A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

16. Radisson Hotel Guayaquil

Kennedy, 2.9 km from Puerto Santa Ana

Jerry

￥13,753 total

Nov 13 - Nov 14

A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

17. Hotel Palace Guayaquil

Rocafuerte, 1.9 km from Puerto Santa Ana

Bethany

￥11,057 total

Nov 15 - Nov 16

A breakfast table with various foods and a view of a park through a window.

18. Unipark by Oro Verde Hotels

Rocafuerte, 2 km from Puerto Santa Ana

Monica

￥11,745 total

Nov 20 - Nov 21

An outdoor seating area with tables and chairs, potted plants, and a view of trees through large windows.

19. Ibis Styles El Malecon Guayaquil

Downtown Guayaquil, 1.7 km from Puerto Santa Ana

Hector

￥10,713 total

Nov 27 - Nov 28

A modern restaurant with a long counter, cushioned seating, and pendant lighting.

20. Hotel Marcelius

Kennedy, 2.7 km from Puerto Santa Ana

Filippo

￥10,786 total

Nov 13 - Nov 14

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Compare popular hotels in Puerto Santa Ana

Property	Star rating	Guest rating
Wyndham Guayaquil Puerto Santa Ana	4.5 star property	9.4 Exceptional 1,011 reviews	View
Luxury Suites Riverfront GYE	3.5 star property	9.4 Exceptional 112 reviews	View
River View suites Puerto Santa Ana gye	3.0 star property	9.0 Wonderful 67 reviews	View
Hotel Río Guayas by Art Hotels Ecuador	4.0 star property	10.0 Exceptional 6 reviews	View
Hostal Macaw	3.0 star property	10.0 Exceptional 11 reviews	View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.

A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

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A colorful outdoor installation with large letters spelling out a word.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

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Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

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A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

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Rosa Elvira

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Top Puerto Santa Ana Hotel Reviews

Wyndham Guayaquil Puerto Santa Ana

Puerto Santa Ana

10/10 Excellent

Sandra

River View suites Puerto Santa Ana gye

Puerto Santa Ana

10/10 Excellent

KAREN

Mansión del Río

Las Peñas

10/10 Excellent

John Thomas

Unipark by Oro Verde Hotels

Downtown Guayaquil

10/10 Excellent

Jose

Holiday Inn Guayaquil Airport by IHG

Guayaquil

10/10 Excellent

Eulalia

Wyndham Garden Guayaquil

Simón Bolívar

10/10 Excellent

Silvia

Courtyard by Marriott Guayaquil

Kennedy

10/10 Excellent

This hotel has convenient, free, parking. It is clean and modern. The staff are all professional, friendly, and speak excellent english. The walls are a little thin but guests are pretty quiet. The pool on the 16th floor is open to the outside and wonderfully warm. The restaurant served an excellent buffet breakfast but dinner was so-so and pricey. I recommend finding dinner elsewhere. The hotel is less than 10 minutes from the airport in Guayaquil and has a free shuttle, which is very...

Robert

Grand Hotel Guayaquil, Centro Histórico.

Downtown Guayaquil

10/10 Excellent

Grand Hotel is a stunning property. They took really good care of us, from airport pick-up to giving us milk for my toddler late at night. The receptionists were happy to help us with directions and answer any queries. The Grand Hotel pool is an oasis, it was breathtaking. We stayed here two nights. Breakfast spread was amazing and the food was delicious. We ate one dinner there too, totally worth it! Excellent service, great staff, breathtaking pool, decent-sized rooms, centrally located!

Niyati

Hotel Palace Guayaquil

Downtown Guayaquil

10/10 Excellent

It was one of my best choices the staff was very courteous always willing to make you feel comfortable. The room is spacious, comfortable and very clean. I slept like a baby. Definitely I would recommend The Palace hotel to anyone you won't regret it. I stayed two nights when I arrived and when I came back i booked the same hotel two more nights just to spend my last days in Guayaquil. One more thing The palace is located in the center of Guayaquil and the Malecon and the Park of the iguanas is...

Angela R.

TRYP by Wyndham Guayaquil Airport

Simón Bolívar

10/10 Excellent

This is my 2nd time staying at this hotel. I got no complaints, and I would definitely come back on my future visit to Ecuador. The staff was very polite, attentive, and responsive. The check-in and check-out process is pretty fast, and there is always someone I can talk to or call. I had a problem this time with the safe box. I had to call twice for someone to come; on my second call, they sent the guy in charge within 10 minutes. It is understandable; there are other people requesting...

Jimmy A

A buffet setup with pastries and various food items in jars.

Sheraton Guayaquil Hotel

Simón Bolívar

10/10 Excellent

They were very kind, patient, and hospitable. Facility was super clean. They are following the CDC’s guidelines for COVID. The community Areas were not crowded. There is outside sitting to eat. The room service also brings up food to your room and all the food is appropriately covered and silverwear is brought in a sealed bag. Food was always delicious and at the appropriate temperature. They also provide a free shuttle to the Airport (which is very close to hotel). Felt super safe to stay here...

Michelle&Fabi

Hotel Ramada

Downtown Guayaquil

10/10 Excellent

Lopez

Frequently Asked Questions

What's it like in Puerto Santa Ana?

Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.

Where is the best hotel for a stay in Puerto Santa Ana?

Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.

How many hotels will I find in Puerto Santa Ana?

If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.

Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?

To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.

What is there to do around this Guayaquil neighborhood?

Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.

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Find hotels in Puerto Santa Ana, Guayaquil from ￥4,999

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Treat yourself

Be picky

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Our top choices for Puerto Santa Ana hotels

1. Wyndham Guayaquil Puerto Santa Ana

2. Luxury Suites Riverfront GYE

3. River View suites Puerto Santa Ana gye

4. Mansión del Río

5. Hotel Río Guayas by Art Hotels Ecuador

6. Wyndham Garden Guayaquil

7. Hotel Ramada

8. Oro Verde Guayaquil

9. Courtyard by Marriott Guayaquil

10. Hotel Patrimonial by Greenfield

11. Holiday Inn Guayaquil Airport by IHG

12. Grand Hotel Guayaquil, Centro Histórico.

13. Hilton Colon Guayaquil

14. Fortune Hotel

15. TRYP by Wyndham Guayaquil Airport

16. Radisson Hotel Guayaquil

17. Hotel Palace Guayaquil

18. Unipark by Oro Verde Hotels

19. Ibis Styles El Malecon Guayaquil

20. Hotel Marcelius

Compare popular hotels in Puerto Santa Ana

Where to stay in Puerto Santa Ana

Ecuador

Downtown Guayaquil

Kennedy

Simón Bolívar

Rosa Elvira

Top Puerto Santa Ana Hotel Reviews

Wyndham Guayaquil Puerto Santa Ana

10/10 Excellent

Frequently Asked Questions

What's it like in Puerto Santa Ana?

Where is the best hotel for a stay in Puerto Santa Ana?

How many hotels will I find in Puerto Santa Ana?

If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?

What is there to do around this Guayaquil neighborhood?

Explore a world of travel with Expedia