Find Resorts & Hotels with Spas in Greenville, MS

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Check availability on Greenville Resorts & Hotels with Spas

Our top choices for Greenville hotels with a spa

Body treatments, aromatherapy, hot stone massages, deep-tissue massages
Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa
3.5 star property
Greenville
7.8 out of 10, Good, (1000)
"Yes! The staff were excellent and the food is always delicious. I always stay here when I’m in town 🤗"
United States
Fiyinfolu
The price is ￥17,725
￥19,498 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Harlow's Casino Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Greenville Hotel Reviews

Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa

10/10 Excellent
"Yes! The staff were excellent and the food is always delicious. I always stay here when I’m in town 🤗"
Fiyinfolu 1-night trip
Posted 8 days ago
Harlow's Casino Resort & Spa

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Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Forget the stress of everyday life and book yourself a lush spa hotel. Check out the live music scene and restaurants in Greenville—your day trip starts here. Enjoy the entertainment choices and riverfront during your vacation. Spa hotels are the perfect way to break away from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Harlow's Casino Resort & Spa is a top spa hotel featuring 3 restaurants, 3 bars, a casino, and a 24-hour fitness center. Enjoy a facial, body scrub, or detox wrap at the onsite spa.
How many spa hotels are there in Greenville?
Among Expedia's 16 accommodation options in Greenville, there is 1 spa hotel.
What's there to see and do in Greenville?
Take in some sights and attractions while you're in Greenville by visiting 1927 Flood Museum, Lake Ferguson, and Greenville Country Club. If you have a bit of extra time while you're in the area, you might want to check out Winterville State Park and Harlow's Casino Resort & Spa.
What is a Greenville spa hotel?
Spa hotels in Greenville have on-site spas and offer services such as facials and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.