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Find Resorts & Hotels with Spas in Greenville, SC

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Check availability on Greenville Resorts & Hotels with Spas

Tonight
Dec 8 - Dec 9
Tomorrow
Dec 9 - Dec 10
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Top Greenville Resorts & Hotels with Spas

Spa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (415)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is ￥44,580
￥50,375 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
Couples treatment rooms, body treatments, body wraps, body scrubs
Hotel Hartness

Hotel Hartness

4.0 star property
Greenville
9.8 out of 10, Exceptional, (624)
"Beautiful location, friendly staff"
United States
Andrew
The price is ￥23,508
￥31,104 total
includes taxes & fees
Dec 15 - Dec 16
Hotel Hartness
Bar (on property)
Hotel Domestique

Hotel Domestique

4.0 star property
Travelers Rest
9.6 out of 10, Exceptional, (30)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is ￥42,716
￥46,988 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hotel Domestique
Exterior
The Orchard Inn

The Orchard Inn

3.0 star property
Saluda
9.4 out of 10, Exceptional, (139)
"Friendly and helpful staff. Excellent breakfast."
United States
John E
The Orchard Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Greenville Hotel Reviews

Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

10/10 Excellent
"Very nice amenities and rooms. Staff was super friendly and very helpful when needed. We will definitely stay at another Drury Inn when traveling or needing a hotel"
Blair 2-night trip
Posted 3 hours ago
Drury Inn & Suites Greenville

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Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center, a bar, and a restaurant. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 683 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate, and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.